J Korean Neuropsychiatr Assoc.
2005 Jan;44(1):125-128.
Dilated Cardiomyopathy Associated with Clozapine
- Affiliations
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- 1Department of Neuropsychiatry, College of Medicine, Hanyang University, Seoul, Korea. ahndh@hanyang.ac.kr
- 2Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
Abstract
- Clozapine is an atypical antipsychotic agent that is more effective than the typical neuroleptics in the treatment of refractory schizophrenia. However, clozapine is also a drug associated with potentially serious adverse effects, such as cardiac complications as well as agranulocytosis. Clozapine-related agranulocytosis has been reported in Korea, whereas clozapine-related cardiac complications have not. We report a 31-year-old male schizophrenia treated with clozapine who developed a dilated cardiomyopathy. We also reviewed literatures on dilated cardiomyopathy associated with clozapine treatment. This report is an attempt to raise the awareness of clozapine-related cardiac complications.
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