- Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity
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Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R
- KMID: 2470885
- J Breast Cancer.
- 2020 Feb;23(1):93-99.
- doi: 10.4048/jbc.2020.23.e2
Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are... -
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- A Case of Donor Cell Leukemia after Allogenic Peripheral Blood Stem Cell Transplantation for Acute Promyelocytic Leukemia with PML-RARA
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Shin WY, Bang HI, Kim J, Kim KH, Won JH, Park R
- KMID: 2466771
- Lab Med Online.
- 2020 Jan;10(1):88-91.
- doi: 10.3343/lmo.2020.10.1.88
Donor cell leukemia (DCL), a rare but fatal complication arising from allogenic stem cell transplantation, is a complex disease associated with multiple pathophysiological processes. Specific diagnosis of DCL distinct from... -
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- Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus
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Cho KO, Jeong KH, Cha JH, Kim SY
- KMID: 2466572
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):81-88.
- doi: 10.4196/kjpp.2020.24.1.81
Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression... -
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- Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis
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Chen L, Zhan CZ, Wang T, You H, Yao R
- KMID: 2466332
- Yonsei Med J.
- 2020 Jan;61(1):20-29.
- doi: 10.3349/ymj.2020.61.1.20
PURPOSE: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomir in carcinogenesis of multiple human cancers. Here, we aimed to further... -
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- Multistaining Optimization for Epstein-Barr Virus–Encoded RNA In Situ Hybridization and Immunohistochemistry of Formalin-Fixed Paraffin-Embedded Tissues Using an Automated Immunostainer
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Ko JN, Jung JK, Park YI, Shin HJ, Huh J, Back S, Kim YJ, Kim JH, Go H
- KMID: 2459580
- J Pathol Transl Med.
- 2019 Sep;53(5):317-326.
- doi: 10.4132/jptm.2019.08.06
BACKGROUND: Single staining is commonly performed for practical pathologic diagnoses. However, this method is limited in its ability to specify cellular morphology and immunophenotype and often requires consumption of limited... -
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- Reclassification of Mongolian Diffuse Gliomas According to the Revised 2016 World Health Organization Central Nervous System Tumor Classification
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Ochirjav E, Enkhbat B, Baldandorj T, Choe G
- KMID: 2459578
- J Pathol Transl Med.
- 2019 Sep;53(5):298-307.
- doi: 10.4132/jptm.2019.07.15
BACKGROUND: The 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors has been modified to incorporate the IDH mutation and 1p/19q co-deletion in the diagnosis of diffuse... -
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- Overexpression of HER2/HER3 and clinical feature of ovarian cancer
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Chung YW, Kim S, Hong JH, Lee JK, Lee NW, Lee YS, Song JY
- KMID: 2457153
- J Gynecol Oncol.
- 2019 Sep;30(5):e75.
- doi: 10.3802/jgo.2019.30.e75
OBJECTIVES: Human epidermal growth factor receptor-2 (HER2) and 3 (HER3) belong to the epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases. In this study, we assessed HER2/HER3... -
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- Discordance of the PAM50 Intrinsic Subtypes Compared with Immunohistochemistry-Based Surrogate in Breast Cancer Patients: Potential Implication of Genomic Alterations of Discordance
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Kim HK, Park KH, Kim Y, Park SE, Lee HS, Lim SW, Cho JH, Kim JY, Lee JE, Ahn JS, Im YH, Yu JH, Park YH
- KMID: 2464419
- Cancer Res Treat.
- 2019 Apr;51(2):737-747.
- doi: 10.4143/crt.2018.342
PURPOSE: We aimed to analyze the discordance between immunohistochemistry (IHC)-based surrogate subtyping and PAM50 intrinsic subtypes and to assess overall survival (OS) according to discordance. MATERIALS AND METHODS: A total of... -
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- Benign Gastric Ulcer with Epstein-Barr Virus Infection Mimicking Malignant Gastric Ulcer
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Gwak JW, Yoo J, Suh SO, Kim J, Oh IS, Bae JY
- KMID: 2442084
- Korean J Gastroenterol.
- 2019 Mar;73(3):177-181.
- doi: 10.4166/kjg.2019.73.3.177
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal... -
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- Image Analysis of HER2 Immunohistochemical Staining of Surgical Breast Cancer Specimens
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Yim K, Park HS, Kim DM, Lee YS, Lee A
- KMID: 2431632
- Yonsei Med J.
- 2019 Feb;60(2):158-162.
- doi: 10.3349/ymj.2019.60.2.158
PURPOSE: Trastuzumab is an effective treatment for human epidermal growth factor receptor 2 (HER2)-amplified breast cancers. We sought to develop a simple protocol for HER2 image analysis of breast cancer... -
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- Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial
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Roh CK, Choi YY, Choi S, Seo WJ, Cho M, Jang E, Son T, Kim HI, Kim H, Hyung WJ, Huh YM, Noh SH, Cheong JH
- KMID: 2431629
- Yonsei Med J.
- 2019 Feb;60(2):132-139.
- doi: 10.3349/ymj.2019.60.2.132
PURPOSE: Clinical implications of single patient classifier (SPC) and microsatellite instability (MSI) in stage II/III gastric cancer have been reported. We investigated SPC and the status of MSI and Epstein-Barr... -
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- Factors that Predict Clinical Benefit of EGFR TKI Therapy in Patients with EGFR Wild-Type Lung Adenocarcinoma
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Kim SY, Myung JK, Kim HR, Na II, Koh JS, Baek HJ, Kim CH
- KMID: 2441731
- Tuberc Respir Dis.
- 2019 Jan;82(1):62-70.
- doi: 10.4046/trd.2018.0004
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancers have emerged as key predictive biomarkers in EGFR tyrosine kinase inhibitor (TKI) treatment. However, a few patients with... -
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- Report on the External Quality Assessment Scheme for Cytogenetics and Molecular Cytogenetics in Korea (2016–2017)
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Kim J, Shin S, Kim B, Lee ST, Kim M, Choi JR
- KMID: 2437187
- J Lab Med Qual Assur.
- 2018 Dec;40(4):188-198.
- doi: 10.15263/jlmqa.2018.40.4.188
In both 2016 and 2017, the cytogenetic and molecular cytogenetic programs conducted three assessments for the Korean Association of External Quality Assessment Service. A total of six cases with chromosomal... -
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- Genetic overgrowth syndrome: A single center's experience
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Cheon CK, Kim YM, Yoon JY, Kim YA
- KMID: 2435944
- J Genet Med.
- 2018 Dec;15(2):64-71.
- doi: 10.5734/JGM.2018.15.2.64
PURPOSE: Overgrowth syndromes are conditions that involve generalized or localized areas of excess growth. In this study, the clinical, molecular, and genetic characteristics of Korean patients with overgrowth syndrome were... -
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- Clinical Implications According to Diagnostic Methods of Human Epidermal Growth Factor Receptor 2 Positivity in Breast Cancer: A Retrospective Study
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Kim BK, Jeong J, Han W, Yoon TI, Seong MK, Jung JH, Jung SH, Lee J, Sun WY, Korean Breast Cancer Society
- KMID: 2434906
- J Breast Dis.
- 2018 Dec;6(2):60-72.
- doi: 10.14449/jbd.2018.6.2.60
PURPOSE: According to American Society of Clinical Oncology/College of American Pathologists guidelines, breast cancer is human epidermal growth factor receptor 2 (HER2) positive if there is HER2 protein overexpression at... -
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- Altered expression of MALAT1 lncRNA in chronic lymphocytic leukemia patients, correlation with cytogenetic findings
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Ahmadi A, Kaviani S, Yaghmaie M, Pashaiefar H, Ahmadvand , Jalili M, Alimoghaddam K, Eslamijouybari M, Ghavamzadeh A
- KMID: 2429307
- Blood Res.
- 2018 Dec;53(4):320-324.
- doi: 10.5045/br.2018.53.4.320
BACKGROUND: Recent studies have devoted much attention to non-protein-coding transcripts in relation to a wide range of malignancies. MALAT1, a long non-coding RNA, has been reported to be associated with... -
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- Clinicohematological parameters and outcomes in a cohort of chronic lymphocytic leukemia patients with Deletion 17p from Pakistan
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Mahmood R, Khan SA, Altaf C, Malik HS, Khadim MT
- KMID: 2429300
- Blood Res.
- 2018 Dec;53(4):276-280.
- doi: 10.5045/br.2018.53.4.276
BACKGROUND: Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the... -
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- Characterizing Atypical BCL6 Signal Patterns Detected by Digital Fluorescence In Situ Hybridization (FISH) Analysis
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Liew M, Rowe LR, Szankasi P, Paxton CN, Kelley T, Toydemir R, Salama ME
- KMID: 2429133
- Ann Lab Med.
- 2018 Nov;38(6):619-622.
- doi: 10.3343/alm.2018.38.6.619
No abstract available. -
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- Ligand-Independent Epidermal Growth Factor Receptor Overexpression Correlates with Poor Prognosis in Colorectal Cancer
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Yun S, Kwak Y, Nam SK, Seo AN, Oh HK, Kim DW, Kang SB, Lee HS
- KMID: 2424807
- Cancer Res Treat.
- 2018 Oct;50(4):1351-1361.
- doi: 10.4143/crt.2017.487
PURPOSE: Molecular treatments targeting epidermal growth factor receptors (EGFRs) are important strategies for advanced colorectal cancer (CRC). However, clinicopathologic implications of EGFRs and EGFR ligand signaling have not been fully... -
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- Detection and genetic characterization of porcine circovirus 3 from aborted fetuses and pigs with respiratory disease in Korea
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Kim SH, Park JY, Jung JY, Kim HY, Park YR, Lee KK, Lyoo YS, Yeo SG, Park CK
- KMID: 2420943
- J Vet Sci.
- 2018 Sep;19(5):721-724.
- doi: 10.4142/jvs.2018.19.5.721
A novel porcine circovirus 3 (PCV3) was first detected in pigs showing porcine dermatitis and nephropathy syndrome, reproductive failure, and multisystemic inflammation in the USA. Herein, we report on PCV3... -
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