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Left Atrial Mechanical Dysfunction Is Associated With Atrial Fibrillation and Recurrent Stroke After Cryptogenic Stroke

Raco J, Shah R, Farbaniec M, Norby FL, Mann M, Gonzalez MD, Naccarelli GV, Maheshwari A

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The Role of Atrial Cardiopathy as a Potential Cause of Embolic Stroke of Undetermined Source

Rizzo AC, Schwarz G, Bonelli A, Pietro AD, Pietro MD, Aruta F, Motto C, Chiara BD, Moreo A, Agostoni EC

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Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease

Wang L, Liu Q, Yue D, Liu J, Fu Y

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Discrepancy Between Ischemic Changes Observed on Non-Enhanced Computed Tomography and Perfusion Imaging: Implications for Decision-Making in Treatment

Broocks G, Fiehler J, Meyer L

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Sodium-Glucose Cotransporter 2 Inhibitor Improves Neurological Outcomes in Diabetic Patients With Acute Ischemic Stroke

Yang W, Kim JM, Chung M, Ha J, Kang DW, Lee EJ, Jeong HY, Jung KH, Sung H, Paeng JC, Lee SH

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Pupillometer-Based Neurological Pupil Index Differential: A Potential Predictor of Post-Stroke Delirium

Noda K, Tanaka T, Abe S, Usui R, Matsumoto M, Arakaki Y, Kida H, Inui R, Kohama K, Washida K, Bhaskar SMM, Koga M, Toyoda K, Ihara M

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Cancer-Associated Stroke: Thrombosis Mechanism, Diagnosis, Outcome, and Therapeutic Strategies

Heo JH, Yun J, Kim KH, Jung JW, Yoo J, Kim YD, Nam HS

Cancer can induce hypercoagulability, which may lead to stroke. This occurs when tumor cells activate platelets as part of their growth and metastasis. Tumor cells activate platelets by generating thrombin...
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Distal Medium Vessel Occlusion Strokes: Understanding the Present and Paving the Way for a Better Future

Nogueira RG, Doheim MF, Al-Bayati AR, Lee JS, Haussen DC, Mohammaden M, Lang M, Starr M, Rocha M, Câmara CPd, Gross BA, Bhatt NR

Distal medium vessel occlusions (DMVOs) are thought to cause as many as 25% to 40% of all acute ischemic strokes and may result in substantial disability amongst survivors. Although intravenous...
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The Influence of Non-High-Density Lipoprotein Cholesterol on the Efficacy of Genotype-Guided Dual Antiplatelet Therapy in Preventing Stroke Recurrence

Xu Q, Meng X, Li H, Xie X, Jing J, Lin J, Jiang Y, Wang Y, Zhao X, Li Z, Liu L, Wang A, Wang Y

Background and Purpose Non-high-density lipoprotein cholesterol (non-HDL-C), which represents the total cholesterol content of all pro-atherogenic lipoproteins, has recently been included as a new target for lipid-lowering therapy in high-risk...
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Deep Learning-Based Automatic Classification of Ischemic Stroke Subtype Using Diffusion-Weighted Images

Ryu WS, Schellingerhout D, Lee H, Lee KJ, Kim CK, Kim BJ, Chung JW, Lim JS, Kim JT, Kim DH, Cha JK, Sunwoo L, Kim D, Suh SI, Bang OY, Bae HJ, Kim DE

Background and Purpose Accurate classification of ischemic stroke subtype is important for effective secondary prevention of stroke. We used diffusion-weighted image (DWI) and atrial fibrillation (AF) data to train a...
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Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment

Ospel JM, Rex N, Oueidat K, McDonough R, Rinkel L, Baird G, Collins S, Jindal G, Alvin MD, Boxerman J, Barber P, Jayaraman M, Smith W, Amirault-Capuano A, Hill MD, Goyal M, McTaggart R

Background and Purpose Infarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether...
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Device Closure or Antithrombotic Therapy After Cryptogenic Stroke in Elderly Patients With a High-Risk Patent Foramen Ovale

Lee PH, Kim JS, Song JK, Kwon SU, Kim BJ, Lee JS, Sun BJ, Woo JS, Ann SH, Suh JW, Kim JY, Lee K, Lee SY, Heo R, Jeong S, Jang JY, Bae JW, Kim YD, Heo SH, Kim JS

Background and Purpose In young patients (aged 18–60 years) with patent foramen ovale (PFO)- associated stroke, percutaneous closure has been found to be useful for preventing recurrent ischemic stroke or...
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A Multimodal Ensemble Deep Learning Model for Functional Outcome Prognosis of Stroke Patients

Jung HS, Lee EJ, Chang DI, Cho HJ, Lee J, Cha JK, Park MS, Yu KH, Jung JM, Ahn SH, Kim DE, Lee JH, Hong KS, Sohn SI, Park KP, Kwon SU, Kim JS, Chang JY, Kim BJ, Kang DW, KOSNI Investigators

Background and Purpose The accurate prediction of functional outcomes in patients with acute ischemic stroke (AIS) is crucial for informed clinical decision-making and optimal resource utilization. As such, this study...
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How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes?

Ospel JM, Rinkel L, Ganesh A, Demchuk A, Heran M, Sauvageau E, Joshi M, Haussen D, Jayaraman M, Coutts S, Yu A, Puetz V, Iancu D, Bang OY, Tarpley J, Holmin S, Kelly M, Tymianski M, Hill M, Goyal M, the ESCAPE-NA1 Investigators

Background and Purpose Infarct volume and other imaging markers are increasingly used as surrogate measures for clinical outcome in acute ischemic stroke research, but how improvements in these imaging surrogates...
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Tenecteplase Versus Alteplase in Medium Vessel Occlusion Ischemic Stroke: A Secondary Analysis of the Alteplase Compared to Tenecteplase Randomized Trial

Bala F, Singh N, Ignacio K, Alhabli I, Ademola A, Alrohimi A, Khosravani H, Tkach A, Catanese L, Dowlatshahi D, Field T, Hunter G, Benali F, Horn M, Demchuk A, Hill M, Sajobi T, Buck B, Swartz R, Almekhlafi M, Menon BK

Background and Purpose The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with...
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Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities

Huang WQ, Lin Q, Tzeng CM

Leukoaraiosis (LA) manifests as cerebral white matter hyperintensities on T2-weighted magnetic resonance imaging scans and corresponds to white matter lesions or abnormalities in brain tissue. Clinically, it is generally detected...
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Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Marasini S, Jia X

With the implementation of improved bystander cardiopulmonary resuscitation techniques and public-access defibrillation, survival after out-of-hospital cardiac arrest (OHCA) has increased significantly over the years. Nevertheless, OHCA survivors have residual anoxia/reperfusion...
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Prevalence and Associations of Dural Arteriovenous Fistulae in Cerebral Venous Thrombosis: Analysis of ACTION-CVT

Shoskes A, Shu L, Nguyen TN, Abdalkader M, Giles J, Amar J, Siegler JE, Henninger N, ElNazeir M, Kasab SA, Klein P, Heldner MR, Antonenko K, Psychogios M, Liebeskind DS, Field T, Liberman A, Esenwa C, Simpkins A, Li G, Frontera J, Kuohn L, Rothstein A, Khazaal O, Aziz Y, Mistry E, Khatri P, Omran SS, Zubair AS, Sharma R, Starke RM, Morcos JJ, Romano JG, Yaghi S, Asdaghi N

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Endovascular Therapy in the Extended Time Window for Large Vessel Occlusion in Patients With Pre-Stroke Disability

Tanaka K, Yamagami H, Qureshi MM, Uchida K, Siegler JE, Nogueira RG, Yoshimura S, Sakai N, Martinez-Majander N, Nagel S, Demeestere J, Puetz V, Haussen DC, Abdalkader M, Olive-Gadea M, Mohammaden MH, Marto JP, Dusart A, Winzer S, Tomppo L, Caparros F, Henon H, Bellante F, Ramos JN, Ortega-Gutierrez S, Sheth SA, Nannoni S, Kaesmacher J, Vandewalle L, Salazar-Marioni S, Farooqui M, Virtanen P, Ventura R, Zaidi S, Castonguay AC, Puri AS, Farzin B, Masoud HE, Klein P, Jesser J, Requena M, Dobrocky T, Kaiser DP, Peltola E, Strambo D, Möhlenbruch MA, Lin E, Ringleb PA, Zaidat OO, Cordonnier C, Roy D, Lemmens R, Ribo M, Strbian D, Fischer U, Michel P, Raymond J, Nguyen TN

Background and Purpose We compared the outcomes of endovascular therapy (EVT) in an extended time window in patients with large-vessel occlusion (LVO) between patients with and without pre-stroke disability. Methods In...
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Prevalence of Cerebral Amyloid Angiopathy Pathology and Strictly Lobar Microbleeds in East-Asian Versus Western Populations: A Systematic Review and Meta-Analysis

Kort AMD, Verbeek MM, Schreuder FH, Klijn CJ, Jäkel L

Background and Purpose Possible differences in the prevalence of cerebral amyloid angiopathy (CAA) in East-Asian compared to Western populations have received little attention, and results so far have been ambiguous....
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