J Cancer Prev.  2016 Mar;21(1):13-20. 10.15430/JCP.2016.21.1.13.

Downregulation of Reactive Oxygen Species in Apoptosis

Affiliations
  • 1College of Pharmacy, Keimyung University, Daegu, Gyeongsan, Korea.
  • 2Department of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea. sjoo@cu.ac.kr

Abstract

Generation of reactive oxygen species (ROS) by diverse anti-cancer drugs or phytochemicals has been closely related with the induction of apoptosis in cancers. Also, the downregulation of ROS by these chemicals has been found to block initiation of carcinogenesis. Therefore, modulation of ROS by phytochemicals emerges as a crucial mechanism to regulate apoptosis in cancer prevention or therapy. This review summarizes the current understanding of the selected chemical compounds and related cellular components that modulate ROS during apoptotic process. Metformin, quercetin, curcumin, vitamin C, and other compounds have been shown to downregulate ROS in the cellular apoptotic process, and some of them even induce apoptosis in cancer cells. The cellular components mediating the downregulation of ROS include nuclear factor erythroid 2-related factor 2 antioxidant signaling pathway, thioredoxin, catalase, glutathione, heme oxygenase-1, and uncoupling proteins. The present review provides information on the relationship between these compounds and the cellular components in modulating ROS in apoptotic cancer cells.

Keyword

Reactive oxygen species; Apoptosis; Neoplasms

MeSH Terms

Apoptosis*
Ascorbic Acid
Carcinogenesis
Catalase
Curcumin
Down-Regulation*
Glutathione
Heme Oxygenase-1
Metformin
Negotiating
Phytochemicals
Quercetin
Reactive Oxygen Species*
Thioredoxins
Ascorbic Acid
Catalase
Curcumin
Glutathione
Heme Oxygenase-1
Metformin
Quercetin
Reactive Oxygen Species
Thioredoxins
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