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Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats

Kang JB, Park DJ, Koh PO

Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral...
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Recombinant Human Thioredoxin-1 Protects Macrophages from Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation and Cell Apoptosis

Zhang H, Liu Q, Lin JL, Wang Y, Zhang RX, Hou JB, Yu B

Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and apoptosis play critical roles in the pathogenesis of atherosclerosis. Thioredoxin-1 (Trx) is an antioxidant that potently protects various cells from oxidative...
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Downregulation of Reactive Oxygen Species in Apoptosis

Jeong CH, Joo SH

Generation of reactive oxygen species (ROS) by diverse anti-cancer drugs or phytochemicals has been closely related with the induction of apoptosis in cancers. Also, the downregulation of ROS by these...
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Peroxiredoxin-3 Is Involved in Bactericidal Activity through the Regulation of Mitochondrial Reactive Oxygen Species

Lee S, Wi SM, Min Y, Lee KY

Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial...
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Exogenous rhTRX reduces lipid accumulation under LPS-induced inflammation

Han GY, Lee EK, Park HW, Kim HJ, Kim CW

Redox-regulating molecule, recombinant human thioredoxin (rhTRX) which shows anti-inflammatory, and anti-oxidative effects against lipopolysaccharide (LPS)-stimulated inflammation and regulate protein expression levels. LPS-induced reactive oxygen intermediates (ROI) and NO production were...
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Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration

Kwon HJ, Hong SK, Yoon WK, Nam KH, Choi IP, Kim DY, Kim HC, Won YS

Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1...
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Studies on In Vivo Function of Peroxiredoxins in Knockout Mice

Yu DY

Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions,...
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Diagnosis and Management of Grain-Induced Asthma

Quirce S, Diaz-Perales A

Grain-induced asthma is a frequent occupational allergic disease mainly caused by inhalation of cereal flour or powder. The main professions affected are bakers, confectioners, pastry factory workers, millers, farmers, and...
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Serum Thioredoxin 1 Level Has Close Relation with Myocardial Damage Amount in Acute Myocardial Infarction Patients

Shim YK, Kim JT, Seong MH, Kim YJ, Shim TJ, Kim SM, Lee SY, Bae JW, Kim KS, Hwang KK, Kim DW, Cho MC

Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1...
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Protective Effects of Peroxiredoxin on Hydrogen Peroxide Induced Oxidative Stress and Apoptosis in Cardiomyocytes

Park KJ, Kim YJ, Kim J, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Cho MC

BACKGROUND AND OBJECTIVES: The redox system is an important anti-oxidative system composed of thioredoxin, thioredoxin reductase, and peroxiredoxin (PRx). The fine details of PRx expression and its protective effects in...
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Analysis of Low Molecular Weight Proteome from H. pylori Cell Extract Using the High Performance Liquid Chromatography

Park JW, Lee KJ, Kim KM, Joo JS, Kwon YC, Youn HS, Song JY, Kang HL, Lee KH, Baik SC, Lee WK, Cho MJ, Rhee KH

Low molecular proteins (LMPs) which are smaller than 20 kDa are difficult to visible on a standard two-dimensional SDS-polyacrylamide gel electrophoresis (2-D SDS-PAGE) map. LMPs must be enriched appropriately to...
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Expression Pattern of the Thioredoxin System in Human Endothelial Progenitor Cells and Endothelial Cells Under Hypoxic Injury

Park KJ, Kim YJ, Choi EJ, Park NK, Kim GH, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Cho MC

BACKGROUND AND OBJECTIVES: The thioredoxin (TRx) system is a ubiquitous thiol oxidoreductase pathway that regulates cellular reduction/oxidation status. Although endothelial cell (EC) hypoxic damage is one of the important pathophysiologic...
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Expression of Peroxiredoxin I in the Epidermis of Vitiligo

Quan G, Piao MS, Choi JY, Chun JS, Lee JB, Lee SC

  • KMID: 2248128
  • Korean J Dermatol.
  • 2008 Jun;46(6):736-741.
BACKGROUND: Although the pathogenesis of vitiligo isn't fully understood, a recent study demonstrates that oxidative stress plays an important role to induce vitiligo. Peroxiredoxin (Prx) is a novel peroxidase family...
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Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity

Yamauchi S, Noguchi T, Ichijo H

Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses...
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Thioredoxin Peroxidases are Differentially Expressed in Developing Tooth Germs in Rats

Kim HJ, Kang JH, Jeon SK, Jung SW, Kim MS, Kim WJ, Oh WM, Lee EJ, Jung JY, Bae CS, Kim SH

  • KMID: 2092887
  • Korean J Anat.
  • 2007 Mar;40(1):27-35.
Thioredoxin peroxidase (prdx)is an antioxidant defense enzyme and is involved in cell differentiation.We elucidated the localization and expression of prdx in the rat tooth germ,which undergoes dynamic morphological changes during...
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Effects of Nicotine, Cotinine and Benzopyrene as Smoke Components on the Expression of Antioxidants in Human Bronchial Epithelial Cells

Kim YS, Lee JH, Kim SH, Kim TH, Sohn JW, Yoon HJ, Park SS, Shin DH

BACKGROUND: Cigarette smoking is an important risk factor for chronic bronchitis and COPD. Airway epithelial cells exposed to cigarette smoke components such as nicotine, cotinine and benzopyrene can generate reactive...
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Plasma Thioredoxin Level and Its Correlation to Myocardial Damage in Patients with Acute Myocardial Infarction who Underwent Successful Primary Angioplasty

Kim KS, Han HS, Lee YS, Bae JW, Hwang KK, Kim DW, Joo SJ, Cho MC

BACKGROUND AND OBJECTIVES: Oxidative stress is thought to play important role in cardiovascular disease. Thioredoxin is an important biomarker for determining the degree of oxidative stress. However, the relationship between...
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Expression of Peroxiredoxin and Thioredoxin in Human Lung Cancer and Paired Normal Lung

Kim YS, Park JH, Lee HL, Shim JY, Choi YI, Oh YJ, Shin SS, Choi YH, Park KJ, Park RW, Hwang SC

  • KMID: 2318648
  • Tuberc Respir Dis.
  • 2005 Aug;59(2):142-150.
BACKGROUND: Continuous growth stimulation by various factors, as well as chronic oxidative stress, may co-exist in many solid tumors, such as lung cancer. A new family of antioxidant proteins, the...
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Investigation of Oxidative Stress and Development of Lower Urinary Tract Symptoms in the Urinary Bladder following Partial Bladder Outlet Obstruction by Proteomic Approach

Shim JH, Kim HJ

  • KMID: 2293813
  • Korean J Urol.
  • 2005 Dec;46(12):1337-1343.
PURPOSE: This study investigated the pathophysiological mechanism using the proteomic approach to detect the marker proteins for the development of lower urinary tract symptoms following a partial bladder outlet obstruction...
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Application of Hantavirus N Protein Expressed by E. coli System

Yu CH, Nam JH, Choi TK, Ju YR, Lee CH, Shin YH, Park KY

  • KMID: 2055007
  • J Bacteriol Virol.
  • 2004 Jun;34(2):147-155.
Hantaan viruses cause haemorrhagic fever with renal syndrome (HFRS), resulting in severe morbidity and mortality in humans. The genome of Hantaan virus is composed of three segmented and single stranded...
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