Gut Liver.  2008 Sep;2(2):74-80.

Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis

• Kim H

Abstract

Cerulein pancreatitis is similar to human edematous pancreatitis, manifesting with dysregulation of digestive enzyme production and cytoplasmic vacuolization, the death of acinar cells, edema formation, and infiltration of inflammatory cells into the pancreas. Reactive oxygen species are involved in nuclear factor-kappaB activation, cytokine expression, apoptosis and pathogenesis of pancreatitis. There is recent evidence that cerulein activates NADPH oxidase, which is a major source of reactive oxygen species during inflammation and apoptosis in pancreatic acinar cells. In addition, the Janus kinase/signal transducer and activator of transcription pathway has been suggested as being involved in inflammatory signaling in the pancreas. This review discusses the involvement of oxidative stress in inflammation and apoptosis in pancreatic acinar cells stimulated with cerulein as an in vitro model of pancreatitis.

Keyword

Cerulein; Pancreatitis; Inflammation; Apoptosis

MeSH Terms

Acinar Cells
Apoptosis
Caerulein
Cytoplasm
Edema
Humans
Inflammation
NADPH Oxidase
Oxidative Stress
Pancreas
Pancreatitis
Reactive Oxygen Species
Transducers
Caerulein
NADPH Oxidase
Reactive Oxygen Species