- Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles
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Ziamajidi N, Daei S, Khajvand-Abedini M, Abbasalipourkabir R, Nourian A
- KMID: 2538695
- Chonnam Med J.
- 2023 Jan;59(1):48-53.
- doi: 10.4068/cmj.2023.59.1.48
Some reports emphasize that zinc oxide nanoparticles (ZnO NPs) are detrimental to the reproductive organs of animals. As such, this research aimed at exploring the apoptotic potential of ZnO NPs... -
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- MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species
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Giri S, Park GH, Choi JS, Ma E, Chun KS, Joo SH
- KMID: 2537582
- Biomol Ther.
- 2023 Jan;31(1):68-72.
- doi: 10.4062/biomolther.2022.127
Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there... -
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- Thrombin Induced Apoptosis through Calcium-Mediated Activation of Cytosolic Phospholipase A2 in Intestinal Myofibroblasts
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Park MJ, Won JH, Kim DK
- KMID: 2537581
- Biomol Ther.
- 2023 Jan;31(1):59-67.
- doi: 10.4062/biomolther.2022.043
Thrombin is a serine protease that participates in a variety of biological signaling through protease-activated receptors. Intestinal myofibroblasts play central roles in maintaining intestinal homeostasis. In this study, we found... -
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- MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells
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Kang YJ, Kwon YH, Jang JY, Lee JH, Lee S, Park Y, Moon HR, Chung HY, Kim ND
- KMID: 2537583
- Biomol Ther.
- 2023 Jan;31(1):73-81.
- doi: 10.4062/biomolther.2022.044
Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA... -
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- Effects of Albizia julibrissin Durazz through Suppression of Mitochondrial Fission and Apoptosis in Cisplatin-induced Acute Kidney Injury
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Lee HJ, Kim KH, Kim YJ, Cho SP, Hong GL, Jung JY
- KMID: 2538140
- Nat Prod Sci.
- 2022 Dec;28(4):194-200.
- doi: 10.20307/nps.2022.28.4.194
Albizia julibrissin Durazz. (AJ; family Minosaceae) is widely distributed worldwide, and its stem bark has been used as a traditional herbal medicine. Acute kidney injury (AKI) is a clinical syndrome... -
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- Effects of cimifugin on cell growth inhibition and cell apoptosis induction in fadu human pharyngeal squamous cell carcinoma
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Park JH, Kim DK
- KMID: 2537678
- Oral Biol Res.
- 2022 Dec;46(4):165-170.
- doi: 10.21851/obr.46.04.202212.165
Cimifugin is an important component of chromones in the dry roots of Saposhnikovia divaricata and is used in treating inflammatory diseases. However, the effect of cimifugin on cancer is unclear.... -
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- Effects of Sangju Honey on Oral Squamous Carcinoma Cells
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Yee N, Kim H, Kim E, Cha YH, Ma L, Cho NE, Kim D, Kim CY, Kim SH, Ryoo Z, Yi J, Kim MO
- KMID: 2538111
- J Cancer Prev.
- 2022 Dec;27(4):.
- doi: 10.15430/JCP.2022.27.4.239
Since ancient times, honey has been used in traditional medicine owing to its pharmacological effects. It possesses anticancer properties. However, the therapeutic implications of Sangju honey in cancer remains unknown.... -
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- Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins
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Jin S, Park Jh, Yun HJ, Oh YN, Oh S, Choi YH, Kim BW, Kwon HJ
- KMID: 2538109
- J Cancer Prev.
- 2022 Dec;27(4):221-228.
- doi: 10.15430/JCP.2022.27.4.221
Cedrol, a sesquiterpene alcohol, isolated from Juniperus chinensis has been reported to inhibit minichromosome maintenance (MCM) proteins as cancer biomarkers in human lung cancer in vitro. In the present study,... -
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- Effect of equipotent doses of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery
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Oh CS, Hong SW, Park S, Kwon Y, Kim SH
- KMID: 2536119
- Korean J Anesthesiol.
- 2022 Dec;75(6):487-495.
- doi: 10.4097/kja.21569
Background: Numerous studies suggest that intravenous propofol is superior to inhaled volatile anesthetic. This study compared the changes in the endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after... -
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- Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling
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Shakya R, Park GH, Joo SH, Shim JH, Choi JS
- KMID: 2534709
- Biomol Ther.
- 2022 Nov;30(6):585-592.
- doi: 10.4062/biomolther.2022.121
Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist... -
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- Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes
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Zhao J, Wu Q, Yang T, Nie L, Liu S, Zhou J, Chen J, Jiang Z, Xiao T, Yang J, Chu C
- KMID: 2534529
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):541-556.
- doi: 10.4196/kjpp.2022.26.6.541
Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important... -
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- Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway
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Fu W, Fang X, Wu L, Hu W, Yang T
- KMID: 2534526
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):511-518.
- doi: 10.4196/kjpp.2022.26.6.511
Sepsis-associated myocardial injury, an invertible myocardial depression, is a common complication of sepsis. Neogambogic acid is an active compound in garcinia and exerts anthelmintic, anti-inflammatory, and detoxification properties. The role of... -
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- Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells
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Kang KR, Kim JS, Lim H, Seo JY, Park JH, Chun HS, Yu SK, Kim HJ, Kim CS, Kim DK
- KMID: 2534521
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):447-456.
- doi: 10.4196/kjpp.2022.26.6.447
The present study was carried out to investigate the effect of Arctigenin on cell growth and the mechanism of cell death elicited by Arctigenin were examined in FaDu human pharyngeal... -
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- Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells
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Trang NTK, Yoo H
- KMID: 2534520
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):439-446.
- doi: 10.4196/kjpp.2022.26.6.439
The antitumoral effects of valdecoxib (Val), an United States Food and Drug Administration-approved anti-inflammatory drug that was withdrawn due to the side effects of increased risk of cardiovascular adverse events,... -
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- Protective Role of Corticosterone against Hydrogen Peroxide-Induced Neuronal Cell Death in SH-SY5Y Cells
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Lee C, Jang JH, Park GH
- KMID: 2534707
- Biomol Ther.
- 2022 Nov;30(6):570-575.
- doi: 10.4062/biomolther.2022.126
Stress breaks body balance, which can cause diverse physiological disorders and worsen preexisting diseases. However, recent studies have reported that controllable stress and overcoming from stress reinforce resilience to resist... -
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- Synthetic Homoisoflavane Derivatives of Cremastranone Suppress Growth of Colorectal Cancer Cells through Cell Cycle Arrest and Induction of Apoptosis
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Shin HE, Lee S, Choi Y, Park S, Kwon S, Choi JK, Seo SY, Lee Y
- KMID: 2534708
- Biomol Ther.
- 2022 Nov;30(6):576-584.
- doi: 10.4062/biomolther.2022.090
Colorectal cancer is diagnosed as the third most prevalent cancer; thus, effective therapeutic agents are urgently required. In this study, we synthesized six homoisoflavane derivatives of cremastranone and investigated their... -
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- MSCs-Derived miR-150-5p-Expressing Exosomes Promote Skin Wound Healing by Activating PI3K/AKT Pathway through PTEN
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Xiu C, Zheng H, Jiang M, Li J, Zhou Y, Mu L, Liu W
- KMID: 2536206
- Int J Stem Cells.
- 2022 Nov;15(4):359-371.
- doi: 10.15283/ijsc21135
Background and Objectives: The goal of this study was to investigate the mechanism of mesenchymal stem cell (MSC)-derived microRNA (miR)-150-5p-expressing exosomes in promoting skin wound healing through activating PI3K/AKT pathway... -
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- Human Umbilical Cord-Derived Mesenchymal Stem Cells Repair SU5416-Injured Emphysema by Inhibiting Apoptosis via Rescuing VEGF-VEGFR2-AKT Pathway in Rats
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Chen Q, Lv L, Zheng C, Pan H, Xu J, Lin J, Deng Z, Qian W
- KMID: 2536209
- Int J Stem Cells.
- 2022 Nov;15(4):395-404.
- doi: 10.15283/ijsc21149
Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a common, frequently-occurring disease and poses a major health concern. Unfortunately, there is current no effective treatment for COPD, particularly emphysema.... -
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- Excretory-Secretory Products of Trichomonas vaginalis Cause Apoptosis in Mouse Sperm in Vitro
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Keum J, Roh J, Ryu JS, Ryu KY
- KMID: 2536003
- Korean J Parasitol.
- 2022 Oct;60(5):357-360.
- doi: 10.3347/kjp.2022.60.5.357
Excretory-secretory products (ESP) of T. vaginalis have been shown to inhibit sperm motility, viability, and functional integrity, leading to a decreased fertilization rate in vitro. This study investigated whether T.... -
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- Anticancer effects of Ulva compressa extracts on FaDu human hypopharangeal squamous carcinoma cells in vitro
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Jang JY, Jung SY, Park BR, Lee SA, Kim CS
- KMID: 2536298
- Int J Oral Biol.
- 2022 Sep;47(3):41-48.
- doi: 10.11620/IJOB.2022.47.3.41
Ulva compressa Linnaeus (UCL) is a green algae seaweed that performs photosynthesis and is used as a food material in some Asian regions including Korea. It is known to... -
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