- Soluble CD40 Levels in Plasma Are Associated with Cardiovascular Disease and in Carotid Plaques with a Vulnerable Phenotype
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Shami A, Edsfeldt A, Bengtsson E, Nilsson J, Shore AC, Natali A, Khan F, Lutgens E, Gonçalves I
- KMID: 2520914
- J Stroke.
- 2021 Sep;23(3):367-376.
- doi: 10.5853/jos.2021.00178
Background and Purpose CD40 and CD40 ligand (CD40L) are costimulatory molecules of the tumor necrosis factor receptor superfamily and well known for their involvement in inflammatory diseases: atherosclerotic mouse models... -
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- Secondary hypoxic ischemia alters neurobehavioral outcomes, neuroinflammation, and oxidative stress in mice exposed to controlled cortical impact
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Oh SK, Park HJ, Yu GG, Jeong SH, Lee SW, Kim H
- KMID: 2520523
- Clin Exp Emerg Med.
- 2021 Sep;8(3):216-228.
- doi: 10.15441/ceem.20.124
Objective Hypoxic ischemia (HI) is a secondary insult that can cause fatal neurologic outcomes after traumatic brain injury (TBI), ranging from mild cognitive deficits to persistent vegetative states. We here... -
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- A Case of Idiopathic Orbital Inflammation Presenting as Isolated Myositis of the Inferior Oblique Muscle
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Kim GH, Park MR
- KMID: 2520216
- J Korean Ophthalmol Soc.
- 2021 Sep;62(9):1309-1314.
- doi: 10.3341/jkos.2021.62.9.1309
Purpose: To report a case of idiopathic orbital inflammation presenting with isolated myositis of the inferior oblique muscle. Case summary: A 54‐year‐old man presented with swelling on the left lower... -
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- Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis
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Kim JH, Shin CY, Jang SW, Kim DS, Lee W, Kim HG, Kim HR
- KMID: 2519406
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):439-448.
- doi: 10.4196/kjpp.2021.25.5.439
DA-9601 is an extract obtained from Artemisia asiatica, which has been reported to have anti-inflammatory effects on gastrointestinal lesions; however, its possible anti-inflammatory effects on the small intestine have not... -
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- Gastroprotective effect of cirsilineol against hydrochloric acid/ ethanol-induced gastric ulcer in rats
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Gong G, Zhao R, Zhu Y, Yu J, Wei B, Xu Y, Cui Z, Liang G
- KMID: 2519403
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):403-411.
- doi: 10.4196/kjpp.2021.25.5.403
This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced... -
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- Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages
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Yin L, Shi C, Zhang Z, Wang W, Li M
- KMID: 2519402
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):395-401.
- doi: 10.4196/kjpp.2021.25.5.395
Extended inflammation and cytokine production pathogenically contribute to a number of inflammatory disorders. Formosanin C (FC) is the major diosgenin saponin found in herb Paris formosana Hayata (Liliaceae), which has... -
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- The effect of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices in rats with polycystic ovary syndrome
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Amanat S, Ashkar F, Eftekhari MH, Tanideh N, Doaei S, Gholamalizadeh M, Koohpeyma F, Mokhtari M
- KMID: 2520000
- Clin Exp Reprod Med.
- 2021 Sep;48(3):236-244.
- doi: 10.5653/cerm.2020.04231
Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, irregular menstruation, ovulatory dysfunction, and insulin resistance. Recent studies have reported the possible role of phytoestrogens in PCOS. This animal study... -
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- Hyaluronic Acid Increases Anti-Inflammatory Efficacy of Rectal 5-Amino Salicylic Acid Administration in a Murine Colitis Model
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Jhundoo HD, Siefen T, Liang A, Schmidt C, Lokhnauth J, Moulari B, Béduneau A, Pellequer Y, Larsen CC, Lamprecht A
- KMID: 2519619
- Biomol Ther.
- 2021 Sep;29(5):536-544.
- doi: 10.4062/biomolther.2020.227
5-amino salicylic acid (5-ASA) is a standard therapy for the treatment of mild to moderate forms of inflammatory bowel diseases (IBD) whereas more severe forms involve the use of steroids... -
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- Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson’s Disease Model Mice
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Kim T, Jeon J, Park JS, Park Y, Kim J, Noh H, Kim HS, Seo H
- KMID: 2519613
- Biomol Ther.
- 2021 Sep;29(5):483-491.
- doi: 10.4062/biomolther.2020.181
Parkinson’s disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the... -
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- Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine
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Choi Y, Jung K, Kim HJ, Chun J, Ahn M, Jee Y, Ko HJ, Moon C, Matsuda H, Tanaka A, Kim J, Shin T
- KMID: 2519892
- Exp Neurobiol.
- 2021 Aug;30(4):308-317.
- doi: 10.5607/en21011
Experimental autoimmune uveitis (EAU) is an animal model of human autoimmune uveitis that is characterized by the infiltration of autoimmune T cells with concurrent increases in pro-inflammatory cytokines and reactive... -
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- Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury
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Lee SE, Yang H, Sung Y, Kim Y, Park SA
- KMID: 2519890
- Exp Neurobiol.
- 2021 Aug;30(4):285-293.
- doi: 10.5607/en21022
Apolipoprotein E (apoE) plays a role in various physiological functions including lipid transport, synaptic plasticity, and immune modulation. Epidemiological studies suggest that the apoE4 allele increases the risk of post-traumatic sequelae.... -
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- Usefulness of delta neutrophil index to predict neurologic outcome in patients with aneurysmal subarachnoid hemorrhage
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Lee Y, You JS, Kong T, Lee HS, Jeon S, Lee JW, Hwang H, Lee H, Chung HS, Park I, Chung SP
- KMID: 2519736
- J Korean Soc Emerg Med.
- 2021 Aug;32(4):315-327.
Objective: Aneurysmal subarachnoid hemorrhage (SAH) is a common emergency condition, resulting in high morbidity and mortality. The delta neutrophil index (DNI), which reflects the fraction of circulating immature granulocytes, is... -
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- A New Look on an Old Issue: Comprehensive Review of Neurotransmitter Studies in Cerebrospinal Fluid of Patients with Schizophrenia and Antipsychotic Effect on Monoamine’s Metabolism
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Gasnier M, Ellul P, Plaze M, Ahad PA
- KMID: 2519539
- Clin Psychopharmacol Neurosci.
- 2021 Aug;19(3):395-410.
- doi: 10.9758/cpn.2021.19.3.395
Neurotransmitters metabolism has a key role in the physiopathology of schizophrenia as demonstrated by studies measuring monoamine metabolites in patient’s cerebrospinal fluid (CSF) since the beginning of the antipsychotic use.... -
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- Patterns of Cerebrospinal Fluid Biomarkers and Amyloid Positron Emission Tomography in a Patient with Cerebral Amyloid Angiopathy-Related Inflammation
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Kim JY, Jo S, Park YJ, Jung HJ, Koo YS, Lee JH
- KMID: 2518935
- J Korean Neurol Assoc.
- 2021 Aug;39(3):172-176.
- doi: 10.17340/jkna.2021.3.9
Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a distinct subset of cerebral amyloid angiopathy characterized by the auto-inflammatory response to amyloid-laden small arteries of cerebral cortex and leptomeninges. Clinical features include... -
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- Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice
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Kim YJ, Yoon DS, Jung UJ
- KMID: 2518751
- Nutr Res Pract.
- 2021 Aug;15(4):431-443.
- doi: 10.4162/nrp.2021.15.4.431
BACKGROUND/OBJECTIVES: Nobiletin (NOB), a citrus flavonoid, is reported to have beneficial effects on cardiovascular and metabolic health. However, there is limited research investigating the effect of long-term supplementation with low-dose... -
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- PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid NeutralizationMediated Anti-Inflammation
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Kim JK, Go EJ, Ko KW, Oh HJ, Han J, Han DK, Park W
- KMID: 2519216
- Tissue Eng Regen Med.
- 2021 Aug;18(4):613-522.
- doi: 10.1007/s13770-021-00338-z
BACKGROUND: Poly(lactic-co-glycolic acid) (PLGA) microspheres have been actively used in various pharmaceutical formulations because they can sustain active pharmaceutical ingredient release and are easy to administer into the body using... -
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- Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing
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Heo JS, Kim S, Yang CE, Choi Y, Song SY, Kim HO
- KMID: 2519211
- Tissue Eng Regen Med.
- 2021 Aug;18(4):537-548.
- doi: 10.1007/s13770-020-00316-x
Background: Human adipose-derived mesenchymal stem cells (AMSCs) are an attractive resource for wound healing because their regenerative capacity improves injury repair. Recently, stem cell-derived exosomes have been shown to play a... -
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- Exosomes from IL-1b-Primed Mesenchymal Stem Cells Inhibited IL-1b- and TNF-a-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells
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Kim M, Shin DI, Choi BH, Min BH
- KMID: 2519210
- Tissue Eng Regen Med.
- 2021 Aug;18(4):525-536.
- doi: 10.1007/s13770-020-00324-x
BACKGROUND: Exosomes from mesenchymal stem cells (MSCs) show anti-inflammatory effect on osteoarthritis (OA); however, their biological effect and mechanism are not yet clearly understood. This study investigated the anti-inflammatory effect and... -
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- Computed Tomography-Derived Myosteatosis and Metabolic Disorders
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Miljkovic I, Vella CA, Allison M
- KMID: 2518890
- Diabetes Metab J.
- 2021 Jul;45(4):482-491.
- doi: 10.4093/dmj.2020.0277
The role of ectopic adipose tissue infiltration into skeletal muscle (i.e., myosteatosis) for metabolic disorders has received considerable and increasing attention in the last 10 years. The purpose of this... -
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- Pathophysiology of neuropathic pain
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Kwon O
- KMID: 2518510
- J Korean Med Assoc.
- 2021 Jul;64(7):468-476.
- doi: 10.5124/jkma.2021.64.7.468
Background: Neuropathic pain is notoriously difficult to manage properly, not only because of its varied nature and the absence of objective diagnostic tools but also because of extensive reciprocal neuronal... -
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