- Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases
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Pae HO, Chung HT
- KMID: 2167992
- Immune Netw.
- 2009 Feb;9(1):12-19.
- doi: 10.4110/in.2009.9.1.12
Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV),... -
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- Effects of Oxidative Stress and Antioxidant on the Expression of Heme Oxygenase-1 in Human RPE
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Kim YJ, Chin HS
- KMID: 2212543
- J Korean Ophthalmol Soc.
- 2009 Aug;50(8):1247-1253.
- doi: 10.3341/jkos.2009.50.8.1247
PURPOSE: To evaluate the effects of oxidative stress and antioxidantson heme oxygenase-1 (HO-1) in cultured human retinal pigment epithelial (RPE) cells. METHODS: Cultured RPE cells were challenged with different concentrations... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Low Dose Carbon Monoxide Inhalation Prevents Chronic Allograft Nephropathy following Kidney Transplantation in Rats. Heme Oxygenase-1 Derivatives Study I
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Yoon M
- KMID: 2211161
- J Korean Surg Soc.
- 2008 May;74(5):323-329.
PURPOSE: Carbon monoxide (CO), a product of heme catalysis by heme oxygenase (HO-1, HO-2, HO-3), induces cytoprotection against ischemia/reperfusion (I/R) injury in a variety of organs such as the heart,... -
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- Possible Role of Heme Oxygenase-1 and Prostaglandins in the Pathogenesis of Cerebral Malaria: Heme Oxygenase-1 Induction by Prostaglandin D2 and Metabolite by a Human Astrocyte Cell Line
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Kuesap J, Na-Bangchang K
- KMID: 1102782
- Korean J Parasitol.
- 2010 Mar;48(1):15-21.
- doi: 10.3347/kjp.2010.48.1.15
Astrocytes are the most abundant cells in the central nervous system that play roles in maintaining the blood-brain-barrier and in neural injury, including cerebral malaria, a severe complication of Plasmodium... -
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- Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
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Choi HC, Lee KY, Lee DH, Kang YJ
- KMID: 2071686
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):309-313.
- doi: 10.4196/kjpp.2009.13.4.309
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested... -
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- Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats
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Park YY
- KMID: 2071669
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):181-187.
- doi: 10.4196/kjpp.2009.13.3.181
Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS)... -
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- Change of Expression and Activity of Heme Oxygenase-1 in Rat Corpus Cavernosum during Low-flow Priapism
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Kim WJ, Jung HK, Jung JH, Kam SC, Hwa JS, Hyun JS
- KMID: 2298704
- Korean J Androl.
- 2004 Aug;22(2):81-86.
PURPOSE: The inducible isoform of heme oxygenase(HO), HO-1, responds to hypoxia. HO-1 regulates vascular smooth muscle tone through carbon monoxide production. To investigate the possible role of HO-1 in low-flow... -
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- Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
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Kim KY, An YM, Kim TW, Jun YH, Lee JE, Jang JH, Kim SK
- KMID: 2358362
- Clin Pediatr Hematol Oncol.
- 2016 Oct;23(2):77-82.
- doi: 10.15264/cpho.2016.23.2.77
BACKGROUND: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food... -
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- Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes
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Lim HS, Jin S, Yun SJ
- KMID: 2152655
- Chonnam Med J.
- 2016 Jan;52(1):45-52.
- doi: 10.4068/cmj.2016.52.1.45
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and... -
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- Effects of Heme Oxygenase-1 Expression in Mycophenolic Acid Induced Apoptosis of Jurkat Cell Lines
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Lee HK, Choi SJ
- KMID: 2211964
- J Korean Surg Soc.
- 2010 Jun;78(6):343-349.
- doi: 10.4174/jkss.2010.78.6.343
PURPOSE: This study demonstrates that pharmacologic induction of heme oygenase-1 (HO-1) along with catalytic activation significantly modulated apoptosis of Jurkat cells induced by mycophenolic acid (MPA). METHODS: Cells were cultured with... -
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- Fraxetin Induces Heme Oxygenase-1 Expression by Activation of Akt/Nrf2 or AMP-activated Protein Kinase α/Nrf2 Pathway in HaCaT Cells
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Kundu J, Chae IG, Chun KS
- KMID: 2367571
- J Cancer Prev.
- 2016 Sep;21(3):135-143.
- doi: 10.15430/JCP.2016.21.3.135
BACKGROUND: Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a coumarin derivative, has been reported to possess antioxidative, anti-inflammatory and neuroprotective effects. A number of recent observations suggest that the induction of heme oxygenase-1 (HO-1)... -
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- Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
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Wang PF, Yao DH, Hu YY, Li Y
- KMID: 2442015
- Biomol Ther.
- 2019 Feb;27(2):222-230.
- doi: 10.4062/biomolther.2018.052
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacterial translocation (BT), which has been involved in the pathogenesis of cirrhosis... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
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Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK
- KMID: 2285575
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):327-334.
- doi: 10.4196/kjpp.2015.19.4.327
The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1... -
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- The Relationship between Heme Oxygenase-1 Expression and Response to Cisplatin Containing Chemotherapy in Advanced Non-Small Cell Lung Cancer
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Yang DK, Roh MS, Lee KE, Kim KN, Lee KN, Choi PJ, Bang JH, Kim BK, Seo HR, Kim MJ, Kim SK, Lee SK, Son CH
- KMID: 2318846
- Tuberc Respir Dis.
- 2006 Mar;60(3):314-320.
BACKGROUND: The overall response (20-30%) to chemotherapy in non-small cell lung cancer (NSCLC) is quite poor. Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme degradation. There is increasing evidence... -
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- Neuroprotective Effects of Betaxolol Mediated by Heme Oxygenase-1 Induction in RGC-5
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Cha JB, Kwon MY, Chung SW, Woo JM
- KMID: 2213854
- J Korean Ophthalmol Soc.
- 2016 Jan;57(1):113-119.
- doi: 10.3341/jkos.2016.57.1.113
PURPOSE: To evaluate the neuroprotective effects of betaxolol (betaxolol hydrochloride) under hypoxic conditions using retinal ganglion cells (RGC-5) and determine whether heme oxygenase-1 (HO-1) expression exerts cytoprotective effects. METHODS: In this... -
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- Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway
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Jin CH, So YK, Han SN, Kim JB
- KMID: 2351675
- Biomol Ther.
- 2016 Sep;24(5):510-516.
- doi: 10.4062/biomolther.2015.194
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK... -
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- Curcumin reduces cold storage-induced damage in human cardiac myoblasts
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Abuarqoub , Green CJ, Foresti R, Motterlini R
- KMID: 1094654
- Exp Mol Med.
- 2007 Apr;39(2):139-148.
Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to... -
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- Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic beta-Cell Injury
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Lee EM, Lee YE, Lee E, Ryu GR, Ko SH, Moon SD, Song KH, Ahn YB
- KMID: 1857502
- Diabetes Metab J.
- 2011 Oct;35(5):469-479.
- doi: 10.4093/dmj.2011.35.5.469
BACKGROUND: Glucose toxicity that is caused by chronic exposure to a high glucose concentration leads to islet dysfunction and induces apoptosis in pancreatic beta-cells. Heme oxygenase-1 (HO-1) has been identified... -
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