Korean J Physiol Pharmacol.  2009 Jun;13(3):181-187. 10.4196/kjpp.2009.13.3.181.

Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats

Affiliations
  • 1Department of Physiology, School of Medicine, Catholic University of Daegu, Daegu 705-718, Korea. yypark@cu.ac.kr

Abstract

Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS) would give a therapeutic advantage. Ferritin and heme oxygenase-1 (HO-1) are increased by oxidative stress and are potential candidates as a predictive biomarker of ARDS. However, the mechanisms responsible for the increases of ferritin and HO-1, and their relationship to ALI, are unclear. In order to elucidate the interactions between ferritin and HO-1, we studied the changes in ferritin and HO-1 levels in serum and bronchoalveolar lavage (BAL) fluid after intestinal I/R injury in rats. Leukocyte number and protein contents in BAL fluid were elevated following I/R, and the increases were attenuated by mepacrine pretreatment. Both serum ferritin and HO-1 concentrations were progressively elevated throughout the 3 h observation period. Mepacrine pretreatment attenuated the increase of serum and BAL fluid ferritin concentrations, but did not suppress the increase of serum HO-1. Moreover, BAL fluid HO-1 levels did not change after I/R or after mepacrine pretreated I/R compared with sham rats. Unlike ferritin, HO-1 levels are not exactly matched with the ALI. Therefore, there might be a different mechanism between the changes of ferritin and HO-1 in intestinal I/R-induced ALI model.

Keyword

Ferritin; Heme oxygenase-1; Ischemia/reperfusion; Acute lung injury; ARDS

MeSH Terms

Acute Lung Injury
Animals
Bronchoalveolar Lavage
Ferritins
Heme
Heme Oxygenase-1
Humans
Imidazoles
Leukocyte Count
Lung
Lung Injury
Nitro Compounds
Oxidative Stress
Quinacrine
Rats
Respiratory Distress Syndrome, Adult
Salicylamides
Ferritins
Heme
Heme Oxygenase-1
Imidazoles
Nitro Compounds
Quinacrine
Salicylamides
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