Immune Netw.  2009 Feb;9(1):12-19. 10.4110/in.2009.9.1.12.

Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases

Affiliations
  • 1Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Korea. htchung@wku.ac.kr

Abstract

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation, forms high concentrations of its enzymatic by-products that can influence various biological events, and this expression is proven to be associated with the resolution of inflammation. The degradation of heme by HO-1 itself, the signaling actions of CO, the antioxidant properties of BV/BR, and the sequestration of ferrous iron by ferritin all concertedly contribute to the anti-inflammatory effects of HO-1. This review focuses on the anti-inflammatory mechanisms of HO-1 actions and its roles in inflammatory diseases.

Keyword

heme oxygenase-1; carbon monoxide; bilirubin/biliverdin; inflammation; nuclear factor E2-related factor-2; mitogen-activated protein kinase

MeSH Terms

Bilirubin
Biliverdine
Carbon Monoxide
Ferritins
Heme
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Inflammation
Iron
Bilirubin
Biliverdine
Carbon Monoxide
Ferritins
Heme
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Iron
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