- Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases
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Pae HO, Chung HT
- KMID: 2167992
- Immune Netw.
- 2009 Feb;9(1):12-19.
- doi: 10.4110/in.2009.9.1.12
Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV),... -
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- Immunohistochemical localization of heme oxygenase isozymes in the aged rat retina
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Lee HY
- KMID: 1558433
- Korean J Anat.
- 2001 Apr;34(2):169-179.
Heme oxygenase (HO)-1 and -2 isozymes are important markers for the oxidative stress. We localized HO-1 and HO-2 immunoreactivities and assessed the effect of aging on distribution of HO in... -
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- Effect of heme oxygenase induction by NO donor on the aortic contractility
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Kim CK, Sohn UD, Lee SY
- KMID: 1606843
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):87-92.
Carbon monoxide (CO) binds to soluble guanylate cyclase to lead its activation and elicits smooth muscle relaxation. The vascular tissues have a high capacity to produce CO, since heme oxygenase-2 (HO-2) is constitutively... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Effect of the Heme Oxygenase Inhibitor on the Hypoxic Ischemic Brain Injury in the Neonatal Rat
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Bang JY, Park PH
- KMID: 1862249
- Korean J Anesthesiol.
- 2006 Jun;50(6):706-713.
- doi: 10.4097/kjae.2006.50.6.706
BACKGROUND: The heme oxygenase system catalyzes the conversion of heme to free iron, carbon monoxide and bilirubin. This study was purposed to evaluate the effect of the heme oxygenase inhibitor,... -
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- Low Dose Carbon Monoxide Inhalation Prevents Chronic Allograft Nephropathy following Kidney Transplantation in Rats. Heme Oxygenase-1 Derivatives Study I
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Yoon M
- KMID: 2211161
- J Korean Surg Soc.
- 2008 May;74(5):323-329.
PURPOSE: Carbon monoxide (CO), a product of heme catalysis by heme oxygenase (HO-1, HO-2, HO-3), induces cytoprotection against ischemia/reperfusion (I/R) injury in a variety of organs such as the heart,... -
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- Role of Carbon Monoxide in Neurovascular Repair Processing
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Choi YK
- KMID: 2429047
- Biomol Ther.
- 2018 Mar;26(2):93-100.
- doi: 10.4062/biomolther.2017.144
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In... -
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- Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
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Choi HC, Lee KY, Lee DH, Kang YJ
- KMID: 2071686
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):309-313.
- doi: 10.4196/kjpp.2009.13.4.309
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested... -
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- Change of Expression and Activity of Heme Oxygenase-1 in Rat Corpus Cavernosum during Low-flow Priapism
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Kim WJ, Jung HK, Jung JH, Kam SC, Hwa JS, Hyun JS
- KMID: 2298704
- Korean J Androl.
- 2004 Aug;22(2):81-86.
PURPOSE: The inducible isoform of heme oxygenase(HO), HO-1, responds to hypoxia. HO-1 regulates vascular smooth muscle tone through carbon monoxide production. To investigate the possible role of HO-1 in low-flow... -
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- Carbon monoxide: present and future indications for a medical gas
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Ryter SW, Choi AM
- KMID: 1501765
- Korean J Intern Med.
- 2013 Mar;28(2):123-140.
- doi: 10.3904/kjim.2013.28.2.123
Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., H2S, nitric... -
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- Immunohistochemical Distribution of Heme Oxygenase Isoenzymes in Developing Rat Retina
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Kang YK, Lee HY, Ahn CS
- KMID: 2206123
- J Korean Ophthalmol Soc.
- 2002 Jul;43(7):1293-1301.
PURPOSE: To analyze and compare the immunohistochemical distributions of HO-1 and HO-2 with the developmental process of retina, focusing on the time of birth and opening eyes because it is... -
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- A Immunohistochemical Study of Expression of Inducible Isoform of Heme Oxygenase on Human Nasal Polyps
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Park SY, Choi TW, Lee JH, Choi SH, Lee JH, Yun KJ
- KMID: 1597343
- Korean J Otolaryngol-Head Neck Surg.
- 2005 May;48(5):619-623.
BACKGROUND AND OBJECTIVES: Nasal polyp is non-neoplastic, chronic inflammatory disease of the nasal mucosa. Oxidative stress may be related to the pathogenesis of nasal polyp. Oxidative stress may be potential... -
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- The Anti-inflammatory Effect of Cobalt-Protoporphyrin for Rats with Epididymitis Induced by Escherichia coli Infection
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Seo IY, Jeong CS, Rim JS
- KMID: 2294243
- Korean J Urol.
- 2006 Jun;47(6):656-660.
- doi: 10.4111/kju.2006.47.6.656
PURPOSE: Heme oxygenase-1 (HO-1), an inducible heat shock protein, catalyzes the heme to iron, biliverdin and carbon monoxide. It also has an inhibitory effect on necrosis and inflammation. Cobalt (III)-protoporphyrin... -
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- Induction of Heme Oxygenase-1 by Traditional Herb Mix Extract Improves MKN-74 Cell Survival and Reduces Stomach Bleeding in Rats by Ethanol and Aspirin in vivo
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Kang YJ, Moon HS, Kim HJ, Seo HG, Lee JH, Chang KC
- KMID: 1512909
- Korean J Physiol Pharmacol.
- 2007 Apr;11(2):65-70.
Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled... -
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- Expression of Heme Oxygenase-1 in Ischemic Colitis
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Yun KJ, Choi SC, Oh JM
- KMID: 772774
- Korean J Gastroenterol.
- 2005 May;45(5):335-339.
BACKGROUND/AIMS: Ischemic colitis is a vascular condition of inadequate blood flow in the colon which leads to colonic inflammation and can cause significant morbidity and mortality. Oxidative stress is... -
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- Rebamipide Protects TNBS Induced Colonic Damage Through Down-regulation of NF-kappaB Activation and Induction of Heme Oxygenase -1 Expression
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Oh JM, Lee JR, Kwon YM, Kim YR, Kim KS, Choi MK, Chung YT
- KMID: 2030769
- Korean J Anat.
- 2005 Feb;38(1):31-38.
Crohn 's disease is characterized by a chronic relapsing inflammation of the bowel in which pro-inflammatory cytokines play an important role. Rebamipide is an anti-gastric ulcer drug with anti-inflammatory properties... -
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- Protective Effects of Inducible HO-1 on Oxygen Toxicity in Rat Brain Endothelial Microvessel Cells
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Yoo SJ, Nakra NK, Ronnett GV, Moon C
- KMID: 2169473
- Endocrinol Metab.
- 2014 Sep;29(3):356-362.
- doi: 10.3803/EnM.2014.29.3.356
BACKGROUND: Reperfusion in ischemia is believed to generate cytotoxic oxidative stress, which mediates reperfusion injury. These stress conditions can initiate lipid peroxidation and damage to proteins, as well as promote... -
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- Cytochrome P-450, Drug Metabolizing Enzymes and Arachidonic Acid Metabolism in Pig Ocular Tissues
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Lee HR, Choi KR, Cho BC
- KMID: 2205166
- J Korean Ophthalmol Soc.
- 1995 Dec;36(12):2095-2107.
The eye is a relatively isolated organ and tends to retain or accumulate compounds within itself. Unless the eye possesses a mechanism for detoxifying drugs and chemicals that are carried... -
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- Expression of Heme Oxygenase-2 and Smooth Muscle Relaxation by Carbon Monoxide in Rat Prostate: Effects of Age and Castration
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Oh HY, Kwon SM, Lee JR, Kim SI, Choi YD, Hong SJ
- KMID: 2293476
- Korean J Urol.
- 2003 Jun;44(6):592-598.
PURPOSE: Carbon monoxide (CO), as well as nitric oxide (NO), have been proposed as potential effectors in the non-adrenergic, non-cholinergic (NANC), nerve-mediated relaxation of the prostate. Attempts were made to... -
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- YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity
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Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC
- KMID: 1600111
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced... -
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