- Respiratory syncytial virus increases eosinophil extracellular traps in a murine model of asthma
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Silveira J, Antunes GL, Gassen RB, Breda RV, Stein RT, Pitrez PM, da Cunha A
- KMID: 2461104
- Asia Pac Allergy.
- 2019 Oct;9(4):e32.
- doi: 10.5415/apallergy.2019.9.e32
BACKGROUND: Respiratory viral infections are the leading cause of asthma exacerbations. Eosinophil activation results in the formation of eosinophil extracellular traps (EETs), which release web-like structures of DNA and proteins... -
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- Ventilation accelerates lung injury in septic mice
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Jung S, Kim S, Cho H, Jeong I, Park J, Jung DI, Yu D
- KMID: 2463592
- J Biomed Transl Res.
- 2019 Sep;20(3):58-64.
- doi: 10.12729/jbtr.2019.20.3.058
Sepsis is one of the systemic inflammatory responses, and it can cause acute respiratory distress syndrome (ARDS). Mechanical ventilation (MV) is one of the best treatments in patients with sepsis... -
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- Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice
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Huang Q, Han L, Lv R, Ling L
- KMID: 2450492
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):251-261.
- doi: 10.4196/kjpp.2019.23.4.251
Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal... -
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- Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation
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Kim HJ, Lee SH, Jeong S, Hong SJ
- KMID: 2448758
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):560-571.
- doi: 10.4168/aair.2019.11.4.560
PURPOSE: Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2. METHODS: Human lung epithelial cells (A549... -
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- Effect of Pyunkang-tang on Inflammatory Aspects of Chronic Obstructive Pulmonary Disease in a Rat Model
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Seo HS, Lee HJ, Lee CJ
- KMID: 2452778
- Nat Prod Sci.
- 2019 Jun;25(2):103-110.
- doi: 10.20307/nps.2019.25.2.103
We investigated the anti-inflammatory effect of Pyunkang-tang extract (PGT), a complex herbal extract based on traditional Chinese medicine that is used in Korea for controlling diverse pulmonary diseases, on cigarette... -
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- The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury
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Jang EA, Kim JY, Tin TD, Song JA, Lee SH, Kwak SH
- KMID: 2449367
- Acute Crit Care.
- 2019 May;34(2):133-140.
- doi: 10.4266/acc.2019.00507
BACKGROUND: Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory... -
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- Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis
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Park SJ, Im DS
- KMID: 2447859
- Biomol Ther.
- 2019 May;27(3):318-326.
- doi: 10.4062/biomolther.2018.131
Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of... -
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- New Diagnostic Guidelines for Idiopathic Pulmonary Fibrosis
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Kwon BS, Song JW
- KMID: 2446972
- Korean J Med.
- 2019 Apr;94(2):173-181.
- doi: 10.3904/kjm.2019.94.2.173
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterized by worsening lung function and dyspnea. The prognosis of IPF patients is poor, as median survival is approximately... -
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- Comparative Evaluation Between the RealStar Pneumocystis jirovecii PCR Kit and the AmpliSens Pneumocystis jirovecii (carinii)-FRT PCR Kit for Detecting P. jirovecii in Non-HIV Immunocompromised Patients
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Huh HJ, Lim KR, Ki CS, Huh K, Shim HJ, Song DJ, Kim YJ, Chung DR, Lee NY
- KMID: 2425973
- Ann Lab Med.
- 2019 Mar;39(2):176-182.
- doi: 10.3343/alm.2019.39.2.176
BACKGROUND: Real-time PCR is more sensitive than microscopic examination for detecting Pneumocystis jirovecii. We compared the performance of two assays for detecting P. jirovecii DNA: the RealStar Pneumocystis jirovecii PCR... -
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- Acute Exogenous Lipoid Pneumonitis Following Siphoning of Diesel Fuel: A Case Report
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Park SY, Yong HS, Kim SK, Kang EY
- KMID: 2442474
- J Korean Soc Radiol.
- 2019 Jan;80(1):141-146.
- doi: 10.3348/jksr.2019.80.1.141
Acute exogenous lipoid pneumonitis is a kind of chemical pneumonitis following the aspiration of volatile hydrocarbon compounds. The clinical and radiological findings are nonspecific. However, it can be diagnosed by... -
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- High-Flow Nasal Cannula Oxygen Delivery during Bronchoalveolar Lavage: A Question of Methodology Influence?
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Singha SK, Esquinas A
- KMID: 2441734
- Tuberc Respir Dis.
- 2019 Jan;82(1):86-87.
- doi: 10.4046/trd.2018.0058
No abstract available. -
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- Clinical Effectiveness of High-Flow Nasal Cannula in Hypoxaemic Patients during Bronchoscopic Procedures
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Chung SM, Choi JW, Lee YS, Choi JH, Oh JY, Min KH, Hur GY, Lee SY, Shim JJ, Kang KH
- KMID: 2441733
- Tuberc Respir Dis.
- 2019 Jan;82(1):81-85.
- doi: 10.4046/trd.2017.0104
BACKGROUND: Bronchoscopy is a useful diagnostic and therapeutic tool. However, the clinical use of high-flow nasal cannula (HFNC) in adults with acute respiratory failure for diagnostic and invasive procedures has... -
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- Exogenous lipoid pneumonia presented by acute eosinophilic pneumonia
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Seong GM, Kim M
- KMID: 2434131
- Allergy Asthma Respir Dis.
- 2019 Jan;7(1):57-60.
- doi: 10.4168/aard.2019.7.1.57
Exogenous lipoid pneumonia is an uncommon medical condition resulting from aspiration or inhalation of oily material. Generally, lipoid pneumonia has nonspecific clinical and radiological presentations, and may be misdiagnosed as... -
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- Acute Respiratory Distress Syndrome With Alveolar Hemorrhage due to Strongyloidiasis Hyperinfection in an Older Patient
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Kim EJ
- KMID: 2439117
- Ann Geriatr Med Res.
- 2018 Dec;22(4):200-203.
- doi: 10.4235/agmr.18.0041
Strongyloides stercoralis is an intestinal nematode that occurs sporadically in temperate areas like Korea. People who are in the immunosuppressed state, over the age of 65 or under the corticosteroid... -
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- Pneumocystis Pneumonia Developing during Treatment of Recurrent Renal Cell Cancer with Nivolumab
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Kim HR, Keam B, Park YS, Kim M, Kim TM, Kim DW, Heo DS
- KMID: 2438050
- Korean J Med.
- 2018 Dec;93(6):571-574.
- doi: 10.3904/kjm.2018.93.6.571
Nivolumab is an immune checkpoint inhibitor approved for the treatment of metastatic cancers. Here, we report the case of a 65-year-old male with recurrent renal cell carcinoma. After six cycles... -
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- Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection
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Song JH, Shim A, Kim YJ, Ahn JH, Kwon BE, Pham TT, Lee J, Chang SY, Ko HJ
- KMID: 2427511
- Biomol Ther.
- 2018 Nov;26(6):576-583.
- doi: 10.4062/biomolther.2017.233
Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular... -
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- Therapeutic Potential of the Rhizomes of Anemarrhena asphodeloides and Timosaponin A-III in an Animal Model of Lipopolysaccharide-Induced Lung Inflammation
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Park BK, So KS, Ko HJ, Kim HJ, Kwon KS, Kwon YS, Son KH, Kwon SY, Kim HP
- KMID: 2427508
- Biomol Ther.
- 2018 Nov;26(6):553-559.
- doi: 10.4062/biomolther.2017.249
Investigations into the development of new therapeutic agents for lung inflammatory disorders have led to the discovery of plant-based alternatives. The rhizomes of Anemarrhena asphodeloides have a long history of... -
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- Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma
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Huang J, Su M, Lee BK, Kim MJ, Jung JH, Im DS
- KMID: 2427506
- Biomol Ther.
- 2018 Nov;26(6):539-545.
- doi: 10.4062/biomolther.2018.006
4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1) is a synthetic phthalimide derivative of a marine compound. PD1 has peroxisome proliferator-activated receptor (PPAR) γ agonistic and anti-inflammatory effects. This study aimed to investigate the effect of... -
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- Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model
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Liang L, Hur J, Kang JY, Rhee CK, Kim YK, Lee SY
- KMID: 2426406
- Korean J Intern Med.
- 2018 Nov;33(6):1210-1223.
- doi: 10.3904/kjim.2017.207
BACKGROUND/AIMS: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin... -
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- Effectiveness and Safety of High-Flow Nasal Cannula Oxygen Delivery during Bronchoalveolar Lavage in Acute Respiratory Failure Patients
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Kim EJ, Jung CY, Kim KC
- KMID: 2420566
- Tuberc Respir Dis.
- 2018 Oct;81(4):319-329.
- doi: 10.4046/trd.2017.0122
BACKGROUND: Bronchoalveolar lavage (BAL) is a necessary procedure for diagnosis of various lung diseases. High-flow nasal cannula (HFNC) oxygen delivery was recently introduced. This study aimed to investigate the safety... -
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