Diabetes Metab J.  2013 Oct;37(5):333-339. 10.4093/dmj.2013.37.5.333.

The Interplay between Autophagy and Aging

  • 1Bio-MAX Institute, Seoul National University School of Biological Sciences, Seoul, Korea. ykjung@snu.ac.kr


Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.


Aging; Autophagy; Caloric restriction; Mitochondria; Stress

MeSH Terms

Caloric Restriction
Reactive Oxygen Species
Aluminum Hydroxide
Reactive Oxygen Species


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