- Anti-Helicobacter pylori, Anti-apoptotic, and Cytoprotective Effects of Threonine Synthesized from Corynebacterium glutamicum in Gastric Epithelial Cells
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An JM, Kim YS, Hong YG, Hah BS, Sohn MS, Hahm KB
- KMID: 2469316
- Korean J Helicobacter Up Gastrointest Res.
- 2019 Dec;19(4):245-256.
- doi: 10.7704/kjhugr.2019.0011
BACKGROUND/AIMS: Among irritants causing gastric ulcer, Helicobacter pylori (H. pylori) might be pivotal, after which eradication became essential way in either inhibiting ulcerogenesis or preventing ulcer recurrence. Since threonine is... -
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- APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia
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Kim H, Seo H, Park Y, Min BJ, Seo ME, Park KD, Shin HY, Kim JH, Kang HJ
- KMID: 2417871
- Cancer Res Treat.
- 2018 Jul;50(3):823-834.
- doi: 10.4143/crt.2017.351
PURPOSE: Mercaptopurine (MP) is one of the main chemotherapeutics for acute lymphoblastic leukemia (ALL). To improve treatment outcomes, constant MP dose titration is essential to maintain steady drug exposure, while... -
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- Effects and Mechanisms of Taurine as a Therapeutic Agent
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Schaffer S, Kim HW
- KMID: 2421732
- Biomol Ther.
- 2018 May;26(3):225-241.
- doi: 10.4062/biomolther.2017.251
Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking... -
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- Melatonin Protects Human Adipose-Derived Stem Cells from Oxidative Stress and Cell Death
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Tan SS, Han X, Sivakumaran P, Lim SY, Morrison W
- KMID: 2403554
- Arch Plast Surg.
- 2016 May;43(3):237-241.
- doi: 10.5999/aps.2016.43.3.237
BACKGROUND: Adipose-derived stem cells (ASCs) have applications in regenerative medicine based on their therapeutic potential to repair and regenerate diseased and damaged tissue. They are commonly subject to oxidative stress... -
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- NAD(P)H-quinone oxidoreductase-1 silencing modulates cytoprotection related protein expression in cisplatin cytotoxicity
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Park SR, Jung JY, Kim YJ, Jung DY, Lee MY, Ryu SY
- KMID: 2368736
- Korean J Vet Res.
- 2016 Mar;56(1):15-21.
- doi: 10.14405/kjvr.2016.56.1.15
NAD(P)H-quinone oxidoreductase-1 (NQO1) is a down-stream target gene of nuclear factor erythroid 2-related factor 2 (Nrf2), and performs diverse biological functions. Recently, NQO1 is recognized as an effective gene for... -
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- Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells
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Fernando P, Piao MJ, Kang KA, Ryu YS, Hewage SR, Chae SW, Hyun JW
- KMID: 2170544
- Biomol Ther.
- 2016 Jan;24(1):75-84.
- doi: 10.4062/biomolther.2015.069
This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging... -
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- Nitric Oxide-Induced Autophagy in MC3T3-E1 Cells is Associated with Cytoprotection via AMPK Activation
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Yang JY, Park MY, Park SY, Yoo HI, Kim MS, Kim JH, Kim WJ, Jung JY
- KMID: 2070790
- Korean J Physiol Pharmacol.
- 2015 Nov;19(6):507-514.
- doi: 10.4196/kjpp.2015.19.6.507
Nitric oxide (NO) is important in the regulation of bone remodeling, whereas high concentration of NO promotes cell death of osteoblast. However, it is not clear yet whether NO-induced autophagy... -
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- Anti-apoptotic effect of fermented Citrus sunki peel extract on chemical hypoxia-induced neuronal injury
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Ko WC, Lee SR
- KMID: 2209879
- J Nutr Health.
- 2015 Oct;48(5):451-456.
- doi: 10.4163/jnh.2015.48.5.451
PURPOSE: Neuronal apoptotic events induced by aging and hypoxic/ischemic conditions is an important risk factor in neurodegenerative diseases such as ischemia stroke and Alzheimer's disease. The peel of Citrus sunki... -
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- Understanding the Role of Heat Shock Protein Isoforms in Male Fertility, Aging and Apoptosis
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Purandhar , Jena PK, Prajapati , Rajput P, Seshadri S
- KMID: 2320775
- World J Mens Health.
- 2014 Dec;32(3):123-132.
- doi: 10.5534/wjmh.2014.32.3.123
Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance... -
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- Protective Effect of Propofol against Hypoxia-reoxygenation Injury in HaCaT Human Keratinocytes
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Kim YH, Kang JM, Kim IR, Lee BY, Yoon JY, Kim CH, Park BS
- KMID: 1737503
- Int J Oral Biol.
- 2014 Jun;39(2):97-105.
The aim of this study was to determine the beneficial effect of propofol on human keratinocytes that have undergone hypoxia reoxygenation (H/R) injury and to investigate whether autophagy is associated... -
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- The Role of Heat Shock Response in Insulin Resistance and Diabetes
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Kondo T, Motoshima , Igata M, Kawashima , Matsumura , Kai H, Araki E
- KMID: 2280700
- Diabetes Metab J.
- 2014 Apr;38(2):100-106.
- doi: 10.4093/dmj.2014.38.2.100
The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in... -
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- Propofol Post-conditioning Protects against COS-7 Cells in Hypoxia/reoxygenation Injury by Induction of Intracellular Autophagy
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Kwak JW, Kim EN, Park BS, Kim YH, Kim YD, Yoon JU, Kim CH, Yoon JY
- KMID: 2345004
- J Korean Dent Soc Anesthesiol.
- 2014 Mar;14(1):49-56.
- doi: 10.17245/jkdsa.2014.14.1.49
BACKGROUND: Propofol (2.6-diisopropylphenol) is a widely used intravenous anesthetic agent for the induction and maintenance of anesthesia during surgeries and sedation for ICU patients. Propofol has a structural similarity to... -
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- Expression of Heat Shock Protein 27 in Prostate Cancer Cell Lines According to the Extent of Malignancy and Doxazosin Treatment
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Lee SW, Lee JW, Chung JH, Jo JK
- KMID: 2320822
- World J Mens Health.
- 2013 Dec;31(3):247-253.
PURPOSE: Heat shock protein 27 (HSP27) is known as the material that plays a role in apoptosis control in tumor and cell protection including the immune response, drug tolerance, and... -
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- The Interplay between Autophagy and Aging
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Pyo JO, Yoo SM, Jung YK
- KMID: 1965979
- Diabetes Metab J.
- 2013 Oct;37(5):333-339.
- doi: 10.4093/dmj.2013.37.5.333
Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various... -
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- Anti-diabetic effect of acid hydrolyzed silk peptides via cytoprotection of pancreas beta-cells and up-regulation of glucose uptake in muscle cells
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Joo SS
- KMID: 2055093
- J Biomed Res.
- 2013 Mar;14(1):28-34.
In this study, we observed anti-diabetic effects of acid hydrolyzed silk peptides, where the amount of peptides in the total amino acid mixture was strictly regulated. Using in vitro diabetes... -
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- Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis
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Shin T, Ahn M, Moon C, Kim S
- KMID: 2133907
- Anat Cell Biol.
- 2012 Dec;45(4):215-220.
- doi: 10.5115/acb.2012.45.4.215
Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis.... -
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- Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB
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Lee KH, Choi EY, Koh SA, Kim MK, Kim KO, Lee SH, Jang BI, Kim SW, Kim SW, Song SK, Choi JH, Kim JR
- KMID: 1022126
- Exp Mol Med.
- 2011 Sep;43(9):501-509.
- doi: 10.3858/emm.2011.43.9.057
Survivin, a member of the inhibitors of apoptosis protein family, is expressed during development and in various human cancers. However, the clinical relevance of survivin in cancer is still a... -
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- Phenylpropanoids in radioregulation: double edged sword
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Kim W, Seong KM, Youn B
- KMID: 1107373
- Exp Mol Med.
- 2011 Jun;43(6):323-333.
- doi: 10.3858/emm.2011.43.6.034
Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals... -
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- Effect of Creatine on the Survival of RGC-5 Cells under Serum Deprivation
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Kim JW, Hong JH, Kang SH, Kim YY
- KMID: 2214583
- J Korean Ophthalmol Soc.
- 2011 May;52(5):618-623.
- doi: 10.3341/jkos.2011.52.5.618
PURPOSE: To evaluate the protective effect of creatine on the survival of retinal ganglion cells after serum deprivation. METHODS: RGC-5 cells were exposed to 5 mM creatine with serum-free media for... -
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- Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
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Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I
- KMID: 1115265
- Exp Mol Med.
- 2010 Dec;42(12):811-822.
- doi: 10.3858/emm.2010.42.12.084
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases,... -
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