World J Mens Health.  2014 Dec;32(3):123-132. 10.5534/wjmh.2014.32.3.123.

Understanding the Role of Heat Shock Protein Isoforms in Male Fertility, Aging and Apoptosis

• Purandhar
• Jena PK
• Prajapati
• Rajput P
• Seshadri S

• KMID: 2320775
• DOI: http://doi.org/10.5534/wjmh.2014.32.3.123

Abstract

Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance to environmental stress, while mitochondria are primary targets in the process of aging, their expression decreasing with age. Mitochondrion also plays a significant role in the process of spermatogenesis. HSPs have been shown to be involved in apoptosis with some of acting as apoptotic inhibitors and are involved in cytoprotection. In this review we discuss the roles of Hsp 27, 60, 70, and 90 in aging and male infertility and have concluded that these particular HSPs can be used as a molecular markers for mitochondrially- mediated apoptosis, aging and male infertility.

Keyword

Aging; Heat-shock proteins; Infertility, male; Mitochondria; Apoptosis

MeSH Terms

Aging*
Apoptosis*
Cytoprotection
Fertility*
Heat-Shock Proteins*
Homeostasis
Humans
Infertility, Male
Male
Mitochondria
Physiological Processes
Protein Isoforms*
Spermatogenesis
Heat-Shock Proteins
Protein Isoforms

Figure

• 

  Fig. 1 Showing the intrinsic and the extrinsic apoptotic pathways. Adapted from Favoloro, et al. Aging (Albany NY) 2012;4:735-42 [78].

• 

  Fig. 2 Diagram summarizing the common mechanism for the role of HSPs in aging and male fertility.

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