- EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca²⺠and Voltage
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Tak MH, Jang Y, Son WS, Yang YD, Oh U
- KMID: 2468883
- Exp Neurobiol.
- 2019 Dec;28(6):658-669.
- doi: 10.5607/en.2019.28.6.658
Anoctamin1 (ANO1) also known as TMEM16A is a transmembrane protein that functions as a Ca²⺠activated chloride channel. Recently, the structure determination of a fungal Nectria haematococca TMEM16 (nhTMEM16) scramblase... -
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- A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea
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Seo JY, Park JH, Pyo JY, Cha YJ, Jung CK, Song DE, Kwak JJ, Park SY, Na HY, Kim JH, Seok JY, Kim HS, Hong SW
- KMID: 2465437
- J Pathol Transl Med.
- 2019 Nov;53(6):378-385.
- doi: 10.4132/jptm.2019.09.18
BACKGROUND: In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for... -
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- The Role of Peroxiredoxin Family in Cancer Signaling
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Kim Y, Jang HH
- KMID: 2454666
- J Cancer Prev.
- 2019 Jun;24(2):65-71.
- doi: 10.15430/JCP.2019.24.2.65
Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells, the six Prx isoforms are ubiquitously expressed... -
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- Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection
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Tsai HC, Chen YH, Yen CM, Chung LY, Wann SR, Lee SS, Chen YS
- KMID: 2453313
- Korean J Parasitol.
- 2019 Jun;57(3):249-256.
- doi: 10.3347/kjp.2019.57.3.249
Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3... -
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- Galectin-4 Interaction with CD14 Triggers the Differentiation of Monocytes into Macrophage-like Cells via the MAPK Signaling Pathway
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Hong SH, Shin JS, Chung H, Park CG
- KMID: 2450202
- Immune Netw.
- 2019 Jun;19(3):e17.
- doi: 10.4110/in.2019.19.e17
Galectin-4 (Gal-4) is a β-galactoside-binding protein mostly expressed in the gastrointestinal tract of animals. Although intensive functional studies have been done for other galectin isoforms, the immunoregulatory function of Gal-4... -
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- Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
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Lee M, Lee KH, Min A, Kim J, Kim S, Jang H, Lim JM, Kim SH, Ha DH, Jeong WJ, Suh KJ, Yang YW, Kim TY, Oh DY, Bang YJ, Im SA
- KMID: 2464392
- Cancer Res Treat.
- 2019 Apr;51(2):451-463.
- doi: 10.4143/crt.2017.341
PURPOSE: Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric... -
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- Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same
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Sahu V, Nigam L, Agnihotri , Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S
- KMID: 2437622
- Cancer Res Treat.
- 2019 Jan;51(1):313-325.
- doi: 10.4143/crt.2018.105
PURPOSE: The p38 mitogen-activated protein kinase (MAPKs) play a crucial role in the production of pro-inflammatory cytokines and over-expression of it increase cytokines which promote cancer. Among four isoforms, p38α... -
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- The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease
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Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH
- KMID: 2447161
- Kidney Res Clin Pract.
- 2018 Sep;37(3):222-229.
- doi: 10.23876/j.krcp.2018.37.3.222
BACKGROUND: This study was undertaken to explore the effects of aging on the kidneys in mouse models of diabetes and chronic kidney disease (CKD), and to compare the expression of... -
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- Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects
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Seo Y, Pak K, Nam HY, Seok JW, Lee MJ, Kim EJ, Lee JM, Kim SJ, Kim IJ
- KMID: 2415538
- Yonsei Med J.
- 2018 Aug;59(6):787-792.
- doi: 10.3349/ymj.2018.59.6.787
PURPOSE: The present study investigated associations between dopamine transporter (DAT) availability and α-synuclein levels in cerebrospinal fluid, as well as synuclein gene (SNCA) transcripts, and the effect of single nucleotide... -
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- TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation
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Albers RE, Selesniemi K, Natale DR, Brown TL
- KMID: 2413507
- Int J Stem Cells.
- 2018 Jun;11(1):111-120.
- doi: 10.15283/ijsc17069
BACKGROUND: Transforming growth factor beta (TGF-β) signaling has been shown to control a large number of critical cellular actions such as cell death, differentiation, and development and has been implicated... -
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- Clusterin Induces MUC5AC Expression via Activation of NF-κB in Human Airway Epithelial Cells
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Bae CH, Na HG, Choi YS, Song SY, Kim YD
- KMID: 2412670
- Clin Exp Otorhinolaryngol.
- 2018 Jun;11(2):124-132.
- doi: 10.21053/ceo.2017.00493
OBJECTIVES: Clusterin (CLU) is known as apolipoprotein J, and has three isoforms with different biological functions. CLU is associated with various diseases such as Alzheimer disease, atherosclerosis, and some malignancies.... -
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- Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque
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Kang DH, Yin GN, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Ryu JK, Suh JK
- KMID: 2419312
- World J Mens Health.
- 2018 May;36(2):139-146.
- doi: 10.5534/wjmh.170005
PURPOSE: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to... -
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- Primary Autosomal Recessive Distal Renal Tubular Acidosis Caused by a Common Homozygous SLC4A1 Mutation in Two Lao Families
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Park E, Phaymany V, Yi ES, Phangmanixay S, Cheong HI, Choi Y
- KMID: 2409208
- J Korean Med Sci.
- 2018 Mar;33(13):e95.
- doi: 10.3346/jkms.2018.33.e95
Primary distal renal tubular acidosis (dRTA) caused by mutations of the SLC4A1 gene, which encodes for erythroid and kidney isoforms of anion exchanger, shows marked difference in inheritance patterns and... -
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- Comparative Characterization of Four Calcium-Binding EF Hand Proteins from Opisthorchis viverrini
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Emmanoch P, Kosa N, Vichasri-Grams S, Tesana S, Grams R, Geadkaew-Krenc A
- KMID: 2408529
- Korean J Parasitol.
- 2018 Feb;56(1):81-86.
- doi: 10.3347/kjp.2018.56.1.81
Four isoforms of calcium binding proteins containing 2 EF hand motifs and a dynein light chain-like domain in the human liver fluke Opisthorchis viverrini, namely OvCaBP1, 2, 3, and 4,... -
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- A Case of Ankyloblepharon-Ectodermal Defect-Cleft Lip and/or Palate (AEC) Syndrome with Missense Mutation in TP63 1657(th)
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Kim YS, Hwang TH, Park SJ, Lee HJ, Kim SH, Kim CH, Lee JH, Lee JS, Choi S
- KMID: 2396836
- Neonatal Med.
- 2017 Nov;24(4):192-196.
- doi: 10.5385/nm.2017.24.4.192
Ankyloblepharon-ectodermal defects-cleft lip and/or palate (AEC) syndrome, also known as Hay-Wells syndrome, is a rare autosomal dominant disorder characterized by congenital ectodermal dysplasia. It is caused by mutations in p63... -
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- Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient
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Kim YJ, Yoon B, Han K, Park BC
- KMID: 2388911
- Ann Dermatol.
- 2017 Oct;29(5):597-601.
- doi: 10.5021/ad.2017.29.5.597
BACKGROUND: Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis. OBJECTIVE:... -
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- Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway
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Kim Y, Kim HG, Han SY, Jeong D, Yang WS, Kim JI, Kim JH, Yi YS, Cho JY
- KMID: 2388699
- Korean J Physiol Pharmacol.
- 2017 Sep;21(5):547-554.
- doi: 10.4196/kjpp.2017.21.5.547
Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however, its role in macrophage-mediated inflammatory responses is not fully understood. In... -
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- Immunohistochemical localization of glucose transporter 1 and 3 in the scrotal and abdominal testes of a dog
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Hahn KR, Jung HY, Yoo DY, Kim JW, Kim YH, Jo YK, Kim GA, Chung JY, Choi JH, Hwang IK, Jang G, Yoon YS
- KMID: 2407424
- Lab Anim Res.
- 2017 Jun;33(2):114-118.
- doi: 10.5625/lar.2017.33.2.114
Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and... -
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- Role of carbonic anhydrases in skin wound healing
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Barker H, Aaltonen M, Pan P, Vähätupa M, Kaipiainen P, May U, Prince S, Uusitalo-Järvinen H, Waheed A, Pastoreková S, Sly WS, Parkkila S, Järvinen
- KMID: 2382696
- Exp Mol Med.
- 2017 May;49(5):e334.
- doi: 10.1038/emm.2017.60
Skin wound closure occurs when keratinocytes migrate from the edge of the wound and re-epithelialize the epidermis. Their migration takes place primarily before any vascularization is established, that is, under... -
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- Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation
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Shin M, Kang HS, Park JH, Bae JH, Song DK, Im SS
- KMID: 2413280
- Endocrinol Metab.
- 2017 Mar;32(1):11-17.
- doi: 10.3803/EnM.2017.32.1.11
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown... -
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