- Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
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Oh CM, Ryu D, Cho S, Jang Y
- KMID: 2471778
- Korean Circ J.
- 2020 May;50(5):395-405.
- doi: 10.4070/kcj.2019.0416
Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP... -
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- Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells
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Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS
- KMID: 2471234
- Allergy Asthma Immunol Res.
- 2020 May;12(3):523-536.
- doi: 10.4168/aair.2020.12.3.523
PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant... -
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- Innate Lymphoid Cells in the Airways: Their Functions and Regulators
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Orimo K, Saito H, Matsumoto , Morita H
- KMID: 2471224
- Allergy Asthma Immunol Res.
- 2020 May;12(3):381-398.
- doi: 10.4168/aair.2020.12.3.381
Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways—including structural cells and immune cells—interact to form a precise defense system... -
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- Enzymes involved in folate metabolism and its implication for cancer treatment
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Kim SE
- KMID: 2471876
- Nutr Res Pract.
- 2020 Apr;14(2):95-101.
- doi: 10.4162/nrp.2020.14.2.95
BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues... -
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- Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
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Kim KS, Park SW, Cho YW, Kim SK
- KMID: 2471725
- Endocrinol Metab.
- 2020 Mar;35(1):97-105.
- doi: 10.3803/EnM.2020.35.1.97
BACKGROUND: To evaluate the association between serum 25-hydroxyvitamin D (25(OH)D) at mid-pregnancy and postpartum glucose intolerance in women with gestational diabetes mellitus (GDM). METHODS: We enrolled 348 pregnant women diagnosed with... -
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- Current Understanding of Mineral and Bone Disorders of Chronic Kidney Disease and the Scientific Grounds on the Use of Exogenous Parathyroid Hormone in Its Management
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Pazianas M, Miller PD
- KMID: 2471309
- J Bone Metab.
- 2020 Feb;27(1):1-13.
- doi: 10.11005/jbm.2020.27.1.1
Chronic Kidney disease (CKD) disturbs mineral homeostasis leading to mineral and bone disorders (MBD). Serum calcium and phosphate (Pi) remain normal until the late stages of CKD at the expense... -
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- Clinical Characteristics and Treatment of Immune-Related Adverse Events of Immune Checkpoint Inhibitors
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Choi J, Lee SY
- KMID: 2471049
- Immune Netw.
- 2020 Feb;20(1):e9.
- doi: 10.4110/in.2020.20.e9
Immune checkpoint inhibitors (ICIs) have been changing the paradigm of cancer treatment. However, immune-related adverse effects (irAEs) have also increased with the exponential increase in the use of ICIs. ICIs... -
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- Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity
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Lee HW, Chung YS, Kim TJ
- KMID: 2471045
- Immune Netw.
- 2020 Feb;20(1):e5.
- doi: 10.4110/in.2020.20.e5
The γδ T cells are unconventional lymphocytes that function in both innate and adaptive immune responses against various intracellular and infectious stresses. The γδ T cells can be exploited as... -
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- Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy
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Kim JH, Kim BS, Lee SK
- KMID: 2471044
- Immune Netw.
- 2020 Feb;20(1):e4.
- doi: 10.4110/in.2020.20.e4
Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies... -
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- Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
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Nishida M, Tanaka T, Mangmool S, Nishiyama , Nishimura
- KMID: 2470805
- J Lipid Atheroscler.
- 2020 Jan;9(1):124-139.
- doi: 10.12997/jla.2020.9.1.124
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully... -
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- Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology
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Kim IY, Park S, Jang J, Wolfe RR
- KMID: 2470804
- J Lipid Atheroscler.
- 2020 Jan;9(1):110-123.
- doi: 10.12997/jla.2020.9.1.110
Like other bodily materials, lipids such as plasma triacylglycerol, cholesterols, and free fatty acids are in a dynamic state of constant turnover (i.e., synthesis, breakdown, oxidation, and/or conversion to other... -
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- Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance
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Al-Fartosy AJM, Awad NA, Mohammed A
- KMID: 2468838
- Ewha Med J.
- 2020 Jan;43(1):1-11.
- doi: 10.12771/emj.2020.43.1.1
OBJECTIVES: We aimed to evaluate the effect of insulin resistance (IR) on serum Intelectin-1 and endocrinological hormones levels in obese and non-obese women with and without polycystic ovary syndrome (PCOS)... -
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- Cardiorenal syndrome
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Kim MG
- KMID: 2467982
- J Korean Med Assoc.
- 2020 Jan;63(1):20-29.
- doi: 10.5124/jkma.2020.63.1.20
To maintain homeostasis of the cardiovascular system, the heart and kidney act bidirectionally. Therefore, acute or chronic dysfunction of one organ can cause dysfunction in the other. This phenomenon is... -
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- Prebiotics in the Infant Microbiome: The Past, Present, and Future
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Miqdady M, Al Mistarihi J, Azaz A, Rawat D
- KMID: 2467889
- Pediatr Gastroenterol Hepatol Nutr.
- 2020 Jan;23(1):1-14.
- doi: 10.5223/pghn.2020.23.1.1
The latest definition of a prebiotic is “a substrate that is selectively utilized by host microorganisms conferring a health benefitâ€; it now includes non-food elements and is applicable to extra-intestinal... -
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- Autophagy in neutrophils
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Shrestha S, Lee JM, Hong CW
- KMID: 2466564
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):1-10.
- doi: 10.4196/kjpp.2020.24.1.1
Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy... -
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- Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review
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Kim H, Kang JS, Jeong HJ
- KMID: 2470434
- Precis Future Med.
- 2019 Dec;3(4):139-145.
- doi: 10.23838/pfm.2019.00107
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated... -
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- Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium
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Seo Y, Oh SJ, Ahn JS, Shin YY, Yang JW, Kim HS
- KMID: 2470016
- Lab Anim Res.
- 2019 Dec;35(4):187-193.
- doi: 10.1186/s42826-019-0029-6
Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, has... -
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- Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies
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Woldeamlak B, Yirdaw K, Biadgo B
- KMID: 2469905
- Korean J Gastroenterol.
- 2019 Dec;74(6):314-320.
- doi: 10.4166/kjg.2019.74.6.314
Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors.... -
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- Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity
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Özcabı B, Demirhan S, Akyol M, Öztürkmen Akay H, Güven A
- KMID: 2469015
- Korean J Pediatr.
- 2019 Dec;62(12):450-455.
- doi: 10.3345/kjp.2019.00248
BACKGROUND: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. PURPOSE: Here we evaluated the ability of LAP to predict NAFLD... -
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- Autophagy, Cellular Aging and Age-related Human Diseases
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Cheon SY, Kim H, Rubinsztein DC, Lee JE
- KMID: 2468882
- Exp Neurobiol.
- 2019 Dec;28(6):643-657.
- doi: 10.5607/en.2019.28.6.643
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of... -
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