J Metab Bariatr Surg.
2016 Jun;5(1):1-3. 10.0000/jmbs.2016.5.1.1.
Glucose Metabolism in the Intestine
- Affiliations
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- 1Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Korea. eyha@dsmc.or.kr
- KMID: 2328898
- DOI: http://doi.org/10.0000/jmbs.2016.5.1.1
Abstract
- Few are familiar with the gluconeogenesis that occurs in the intestine under fasting or the influence of insulin. Recently, however, studies that revealed the function of intestinal gluconeogenesis as a regulatory process for glucose homeostasis and appetite were described. The intestine produces about 25% of total endogenous glucose during fasting and regulates energy homeostasis through communication with the brain. Glucose produced via intestinal gluconeogenesis is delivered to portal vein where periportal neural system senses glucose and sends a signal to the brain to regulate appetite and glucose homeostasis. Moreover, studies uncovered that intestinal gluconeogenesis contributes to the rapid metabolic improvements induced by gastric bypass surgery.
