- Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus
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Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2470012
- Lab Anim Res.
- 2019 Dec;35(4):154-164.
- doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into... -
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- Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
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Park S, Park JA, Jeon JH, Lee Y
- KMID: 2456216
- Biomol Ther.
- 2019 Sep;27(5):423-434.
- doi: 10.4062/biomolther.2019.051
HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in... -
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- MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
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Zhang C, Dai J, Fan Y, He X, Wei R
- KMID: 2448356
- Korean J Intern Med.
- 2019 May;34(3):634-642.
- doi: 10.3904/kjim.2016.315
BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples.... -
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- Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection
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Song JH, Shim A, Kim YJ, Ahn JH, Kwon BE, Pham TT, Lee J, Chang SY, Ko HJ
- KMID: 2427511
- Biomol Ther.
- 2018 Nov;26(6):576-583.
- doi: 10.4062/biomolther.2017.233
Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular... -
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- S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion
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Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH
- KMID: 2420062
- J Korean Neurosurg Soc.
- 2018 Sep;61(5):548-558.
- doi: 10.3340/jkns.2017.0200
OBJECTIVE: Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently... -
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- Identification of determinants that mediate binding between Tembusu virus and the cellular receptor heat shock protein A9
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Zhao D, Liu Q, Huang X, Wang H, Han K, Yang J, Bi K, Liu Y, Zhang L, Li Y
- KMID: 2417568
- J Vet Sci.
- 2018 Jul;19(4):528-535.
- doi: 10.4142/jvs.2018.19.4.528
Heat shock protein A9 (HSPA9), a member of the heat shock protein family, is a putative receptor for Tembusu virus (TMUV). By using Western blot and co-immunoprecipitation assays, E protein... -
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- Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27
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Kim YS, Jeong M, Han YM, Park JM, Kwon SO, Hong SP, Hahm KB
- KMID: 2407670
- Korean J Gastroenterol.
- 2018 Mar;71(3):132-142.
- doi: 10.4166/kjg.2018.71.3.132
BACKGROUND/AIMS: Several lines of evidence from epidemiologic and laboratory studies have shown that the consumption of Artemisia or green tea extracts (MPGT) is inversely associated with the risk of alcohol-induced... -
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- Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid
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Yoo K, Suh KY, Choi GH, Kwak IS, Seo DK, Kym D, Yoon H, Cho YS, Kim HO
- KMID: 2394843
- Ann Dermatol.
- 2017 Apr;29(2):194-199.
- doi: 10.5021/ad.2017.29.2.194
BACKGROUND: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no... -
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- Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90
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Jun KY, Kwon Y
- KMID: 2351668
- Biomol Ther.
- 2016 Sep;24(5):453-468.
- doi: 10.4062/biomolther.2016.168
There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The... -
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- Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer
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Park Y, Lee KS, Park SY, Kim JH, Kang EY, Kim SW, Eom KY, Kim JS, Kim IA
- KMID: 2407572
- J Breast Cancer.
- 2015 Sep;18(3):249-255.
- doi: 10.4048/jbc.2015.18.3.249
PURPOSE: Histone deacetylase 6 (HDAC6) is an enzyme that deacetylates heat-shock protein 90 (HSP90). Many studies have investigated the role of HDAC6 and HSP90 in tumorigenesis and in the prognosis... -
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- Silencing of Heat Shock Protein 27 Expression Accelerates Doxazosin-induced Apoptosis in Prostate Cancer Cell Line PC-3
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Shin SC, Cho JM, Kang JY, Yoo TK, Cho H
- KMID: 2307839
- Korean J Urol Oncol.
- 2015 Aug;13(2):93-100.
- doi: 10.0000/kjuo.2015.13.2.93
PURPOSE: Heat shock proteins (HSPs) are highly expressed during stress responses and cellular adaptation to environmental changes. One such protein is HSP27, a 27kDa protein that prevents cell death induced... -
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- The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression
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Choi DW, Lim MS, Lee JW, Chun W, Lee SH, Nam YH, Park JM, Choi DH, Kang CD, Lee SJ, Park SC
- KMID: 2380345
- Biomol Ther.
- 2015 Mar;23(2):128-133.
- doi: 10.4062/biomolther.2014.133
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins... -
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- Expression of Heat Shock Protein 27 and Alpha B Crystallin in the Retina and Optic Nerve of the Chick Embryo
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Seo JH, Kim JY
- KMID: 2283745
- Korean J Phys Anthropol.
- 2015 Mar;28(1):37-44.
- doi: 10.11637/kjpa.2015.28.1.37
Heat shock protein 27 (HSP27) and alpha B crystallin (aBC) belong to the small heat shock protein (sHSP) family and have similar amino acid sequences. However, no study has compared... -
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- Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
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Seo YH
- KMID: 2171313
- J Cancer Prev.
- 2015 Mar;20(1):5-11.
- doi: 10.15430/JCP.2015.20.1.5
Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins including epidermal growth... -
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- Heat Shock Protein 90 (HSP90) and Immune Regulation
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Kim BK, Woo SY
- KMID: 2168706
- J Bacteriol Virol.
- 2015 Mar;45(1):62-66.
- doi: 10.4167/jbv.2015.45.1.62
Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating... -
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- Understanding the Role of Heat Shock Protein Isoforms in Male Fertility, Aging and Apoptosis
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Purandhar , Jena PK, Prajapati , Rajput P, Seshadri S
- KMID: 2320775
- World J Mens Health.
- 2014 Dec;32(3):123-132.
- doi: 10.5534/wjmh.2014.32.3.123
Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance... -
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- Human CD103+ dendritic cells promote the differentiation of Porphyromonas gingivalis heat shock protein peptide-specific regulatory T cells
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Kim MJ, Jeong EK, Kwon EY, Joo JY, Lee JY, Choi J
- KMID: 2027821
- J Periodontal Implant Sci.
- 2014 Oct;44(5):235-241.
- doi: 10.5051/jpis.2014.44.5.235
PURPOSE: Regulatory T cells (Tregs), expressing CD4 and CD25 as well as Foxp3, are known to play a pivotal role in immunoregulatory function in autoimmune diseases, cancers, and graft rejection.... -
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- Expression of Heat Shock Proteins and Cytokines in Response to Ethanol Induced Damage in the Small Intestine of ICR Mice
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Lee SW, Choi DW, Park SC, Kim HJ, Nam YH, Choi DH, Kang CD, Lee SJ, Chun WJ, Ryu YJ
- KMID: 2174379
- Intest Res.
- 2014 Jul;12(3):205-213.
- doi: 10.5217/ir.2014.12.3.205
BACKGROUND/AIMS: Ethanol administration causes intestinal epithelial cell damage by increasing intestinal permeability and the translocation of endotoxins from intestinal bacterial flora. Heat shock proteins (HSPs) are associated with recovery and... -
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- The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer
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Kang HJ, Moon HS, Chung HW
- KMID: 1841539
- Obstet Gynecol Sci.
- 2014 Jul;57(4):281-290.
- doi: 10.5468/ogs.2014.57.4.281
OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation... -
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- Characterize and Gene Expression of Heat Shock Protein 90 in Marine Crab Charybdis japonica following Bisphenol A and 4-Nonylphenol Exposures
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Park K, Kwak IS
- KMID: 2380095
- Environ Health Toxicol.
- 2014 ;29(1):e2014002.
OBJECTIVES: Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone important in the maturation of a broad spectrum of protein. In this study, an HSP90 gene was isolated... -
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