J Bacteriol Virol.  2015 Mar;45(1):62-66. 10.4167/jbv.2015.45.1.62.

Heat Shock Protein 90 (HSP90) and Immune Regulation

• Kim BK
• Woo SY

• KMID: 2168706
• DOI: http://doi.org/10.4167/jbv.2015.45.1.62

Abstract

Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating humoral and cellular immune responses. Therefore, HSP90 inhibitors potentially useful target for the autoimmune disease and chronic inflammatory diseases.

Keyword

Heat shock protein 90 (HSP90); Anti-inflammatory; HSP90 inhibitor; IL-17; Act1

MeSH Terms

Autoimmune Diseases
Heat-Shock Proteins*
Immunity, Cellular
Interleukin-17
Transcription Factors
Heat-Shock Proteins
Interleukin-17
Transcription Factors

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