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Two Types of Mouse Models for Sarcopenia Research: Senescence Acceleration and Genetic Modification Models

Baek KW, Jung YK, Park JS, Kim JS, Hah YS, Kim SJ, Yoo JI

Sarcopenia leads to loss of skeletal muscle mass, quality, and strength due to aging; it was recently given a disease code (International Classification of Diseases, Tenth Revision, Clinical Modification, M62.84)....
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Clinical Practice Guideline for Frailty Applicable in Primary Care Setting

You HS, Kwon YJ, Kim S, Kim YH, Kim Ys, Kim Y, Roh Yk, Park B, Park YK, Park CH, Son JS, Shin J, Shin HY, Oh B, Lee Jw, Shim JY, Won CW, Yoo JW, Lee SH, Kang HT, Lee DC

With aging becoming a global issue, the interest in healthy aging has increased as well. Healthy aging focuses on maintaining the functions and wellbeing of the elderly rather than merely...
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Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene

Hoang NMH, Kim S, Nguyen HD, Kim M, Kim J, Kim BC, Park D, Lee S, Yu BP, Chung HY, Kim MS

1,2-Diacetylbenzene (DAB) is a metabolite of 1,2-diethylbenzene, which is commonly used in the manufacture of plastics and gasoline. We examined the neurotoxic effects of DAB in young and old rats,...
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Arterial Spin Labeling Magnetic Resonance Imaging in Healthy Adults: Mathematical Model Fitting to Assess Age-Related Perfusion Pattern

Hu Y, Liu R, Gao F

Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy...
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Growth Hormone and Aging: New Findings

Bartke A, Hascup E, Hascup K, Masternak MM

Complex relationships between growth hormone (GH) signaling and mammalian aging continue to attract attention of many investigators. Recent results include evidence that the impact of GH on genome maintenance (DNA...
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Evaluation of Age- and Radical-Prostatectomy Related Changes in Male Pelvic Floor Anatomy Based on Magnetic Resonance Imaging and 3-Dimensional Reconstruction

Tai JW, Sorkhi SR, Trivedi I, Sakamoto K, Albo M, Bhargava V, Rajasekaran MR

Purpose: Puborectalis muscles (PRM) and ischiocavernosus muscles (ICM) play important roles in urinary continence and male erectile functions. Understanding of anatomy and surgical-injury related changes to these muscles is critical...
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A Korean nationwide investigation of the national trend of complex regional pain syndrome vis-à-vis age-structural transformations

Lee JH, Park S, Kim JH

Background: The present study employed National Health Insurance Data to explore complex regional pain syndrome (CRPS) updated epidemiology in a Korean context. Methods: A CRPS cohort for the period 2009-2016 was...
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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics

Yoon JH, Kwon KS

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement...
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The Effects of Climacteric Symptom Cognition, Self-efficacy on Aging Anxiety in Middle-Aged Couples: Actor and Partner Interdependence Mediation Model

Kim YS, Hur MH

Purpose: This study aimed to construct and test the Actor and Partner Interdependence Mediation Model (APIMeM) of aging anxiety of middle-aged couples based on Social Cognitive Theory and the “Crossover”...
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Normative Study of the Block Design Test for Adults Aged 55 Years and Older in Korean Aging Population

Joung H, Yi D, Ahn H, Lee Y, Byun MS, Sung K, Han D, Lee DY, KBASE Research Group

Objective The Block Design Test (BDT) is known to be an effective measure in diagnosing age-related cognitive decline of visuospatial function. The goal of this study is to investigate the...
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Pathogenesis and prevention of skin aging

Cho S

Background: As global life expectancy increases, an interest in maintaining health and beauty in old age has increased. As a barrier organ, the skin is an ideal model for studying...
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Comparison of Human Interpretation and a Rule-Based Algorithm for Instrumented Sit-to-Stand Test

Jung HW, Yoon S, Baek JY, Lee E, Jang IY, Roh H

Background: The five times sit-to-stand test (5STS) is one of the most commonly used tests to assess the physical performance of lower extremities. This study assessed the correlation between human...
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Voluntary Wheel Running Exercise Improves Aging-Induced Sarcopenia via Activation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α/Fibronectin Type III Domain-Containing Protein 5/Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

Ko YJ, Ko IG

Purpose: In this study, the protective effect of voluntary wheel running exercise on muscle loss and muscle weakness in gastrocnemius of old rats was investigated. The association of voluntary wheel...
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Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1α/Nrf2 signaling pathway

Wang H, Shi X, Cheng L, Han J, Mu J

The present study explored the therapeutic potential of hydrogen sulfide (H2 S) in restoring aging-induced loss of cardioprotective effect of remote ischemic preconditioning (RIPC) along with the involvement of signaling...
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Mediating Effects of Smartphone Utilization between Attitude and Willingness to Use Home-Based Healthcare ICT among Older Adults

Jo HS, Hwang YS, Dronina Y

Objectives: This study explored the direct and indirect effects of knowledge of new technology (e.g., artificial intelligence, the Internet of Things, and the Fourth Industrial Revolution), attitudes towards technology use,...
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The senior anesthesiologists and their medical profession in Korea: based on a survey

Kim K, Baek S, Choi IC, Yang HS

Background: The number of aging physicians is increasing as the global population ages. With aging, anesthesiologists would be expected to experience changes in their professional position. Therefore, we aimed to...
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Healthy Living Characteristics of Elderly People with Hypertension According to Household Types Using the 7th Korean National Health and Nutrition Survey (2016–2018)

Park HJ, Song YK, Jo JB, Lee DH, Ju J, Shim SM

Background: Recently, the rapid aging of the Korean population has caused social problems, and the number of elderly people living alone has increased. Hypertension, the most prevalent chronic disease in...
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Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults

Kim DA, Park SJ, Lee JY, Kim JH, Lee S, Lee E, Jang IY, Jung HW, Park JH, Kim BJ

Background: The C-C motif chemokine ligand 11 (CCL11) has been receiving attention as a potential pro-aging factor. Accordingly, it may be involved in muscle metabolism and sarcopenia, a key component...
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Vitamin D Deficiency and Risk of Metabolic Syndrome in Aging Men

D’Amelio P

The elderly population is rapidly increasing; hence, the disability due to age-related diseases has become an important socioeconomic burden. Amongst age-related diseases cardiovascular ones (CVD) have a huge impact on...
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Energy Metabolism and Aging

Bartke A, Brannan S, Hascup E, Hascup K, Darcy J

Aging is strongly related to energy metabolism, but the underlying processes and mechanisms are complex and incompletely understood. Restricting energy intake and reducing metabolic rate can slow the rate of...
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