- The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy
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Hu L, Bai Z, Ma X, Bai N, Zhang Z
- KMID: 2471929
- J Gastric Cancer.
- 2020 Mar;20(1):95-105.
- doi: 10.5230/jgc.2020.20.e9
PURPOSE: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3... -
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- Autophagy in neutrophils
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Shrestha S, Lee JM, Hong CW
- KMID: 2466564
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):1-10.
- doi: 10.4196/kjpp.2020.24.1.1
Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy... -
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- Autophagy, Cellular Aging and Age-related Human Diseases
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Cheon SY, Kim H, Rubinsztein DC, Lee JE
- KMID: 2468882
- Exp Neurobiol.
- 2019 Dec;28(6):643-657.
- doi: 10.5607/en.2019.28.6.643
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of... -
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- Asiatic Acid Induces Apoptosis and Autophagy and Reduces MiR-17 and MiR-21 Expression in Pancreatic Cancer Cell Lines
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Jo YG, Kim M, Shin H, Lee KY, Lee EJ
- KMID: 2468062
- Nat Prod Sci.
- 2019 Dec;25(4):298-303.
- doi: 10.20307/nps.2019.25.4.298
This study investigated the cytotoxic effects and mechanism of action of asiatic acid in pancreatic cancer cell lines. First, we confirmed the cell viability of MIA PaCa-2 and PANC-1 cells... -
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- Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation
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Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L
- KMID: 2463799
- Yonsei Med J.
- 2019 Dec;60(12):1195-1202.
- doi: 10.3349/ymj.2019.60.12.1195
PURPOSE: The aim of this study was to investigate whether propofol could attenuate hypoxia/reoxygenation-induced apoptosis and autophagy in human renal proximal tubular cells (HK-2) by inhibiting JNK activation. MATERIALS AND METHODS:... -
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- Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes
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Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS
- KMID: 2462884
- Biomol Ther.
- 2019 Nov;27(6):570-576.
- doi: 10.4062/biomolther.2019.025
Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can... -
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- Autophagy localization and cytoprotective role in cisplatin-induced acute kidney injury
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- KMID: 2461010
- Korean J Vet Res.
- 2019 Sep;59(3):133-139.
- doi: 10.14405/kjvr.2019.59.3.133
Autophagy is a fundamental cellular process that maintains homeostasis and cell integrity, under stress conditions. Although the involvement of autophagy in various conditions has been elucidated, the role of autophagy... -
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- Effect of a Single Bout of Exercise on Autophagy Regulation in Skeletal Muscle of High-Fat High-Sucrose Diet-Fed Mice
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Zhang D, Lee JH, Kwak SE, Shin HE, Zhang Y, Moon HY, Shin DM, Seong JK, Tang L, Song W
- KMID: 2459812
- J Obes Metab Syndr.
- 2019 Sep;28(3):175-185.
- doi: 10.7570/jomes.2019.28.3.175
BACKGROUND: Autophagy maintains metabolic homeostasis of muscles, and its impairment may cause muscle dysfunction. Exercise can improve muscle dysfunction induced by long-term high-fat diet. This study aimed to explore the... -
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- Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
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Kim JH, Kim KM, Jeong JU, Shin JH, Shin JM, Bang KT
- KMID: 2457723
- Kidney Res Clin Pract.
- 2019 Sep;38(3):318-325.
- doi: 10.23876/j.krcp.18.0152
BACKGROUND: Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. METHODS: Using human renal... -
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- Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiR-186-5p/MAP4K3 Axis in Hepatocellular Carcinoma
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Shan Y, Li P
- KMID: 2457480
- Yonsei Med J.
- 2019 Sep;60(9):842-853.
- doi: 10.3349/ymj.2019.60.9.842
PURPOSE: Long intergenic non-protein coding RNA 665 (LINC00665) plays a vital role in the development of cancer. Its function in hepatocellular carcinoma (HCC), however, remains largely unknown. MATERIALS AND METHODS: The... -
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- Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172 Human Glioblastoma Cells
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Lee JE, Yoon SS, Moon EY
- KMID: 2456223
- Biomol Ther.
- 2019 Sep;27(5):484-491.
- doi: 10.4062/biomolther.2019.107
Glioblastoma is the most aggressive common brain tumor in adults. Curcumin, from Curcuma longa, is an effective antitumor agent. Although the same proteins control both autophagy and cell death, the... -
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- Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
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Ko JY, Lee EJ, Park JH
- KMID: 2455087
- Biomol Ther.
- 2019 Jul;27(4):337-341.
- doi: 10.4062/biomolther.2019.056
Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between... -
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- Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells
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Ha S, Jeong SH, Yi K, Chu JJ, Kim S, Kim EK, Yu SW
- KMID: 2450215
- Exp Neurobiol.
- 2019 Apr;28(2):229-246.
- doi: 10.5607/en.2019.28.2.229
Neural stem cells (NSCs) have the ability to self-renew and differentiate into neurons, oligodendrocytes, and astrocytes. Highly dynamic nature of NSC differentiation requires the intimate involvement of catabolic processes such... -
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- The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells
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Jung HE, Shim YR, Oh JE, Oh DS, Lee HK
- KMID: 2444160
- Immune Netw.
- 2019 Apr;19(2):e12.
- doi: 10.4110/in.2019.19.e12
Hematopoietic stem cells (HSCs) in bone marrow are pluripotent cells that can constitute the hematopoiesis system through self-renewal and differentiation into immune cells and red blood cells. To ensure a... -
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- The Role of Autophagy in Eosinophilic Airway Inflammation
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Lee J, Kim HS
- KMID: 2438913
- Immune Netw.
- 2019 Feb;19(1):e5.
- doi: 10.4110/in.2019.19.e5
Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory... -
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- Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells
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Sung SJ, Kim HK, Hong YK, Joe YA
- KMID: 2432075
- Biomol Ther.
- 2019 Jan;27(1):117-125.
- doi: 10.4062/biomolther.2018.222
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the... -
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- Transglutaminase 2 Promotes Autophagy by LC3 Induction through p53 Depletion in Cancer Cell
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Kang JH, Lee SH, Cheong H, Lee CH, Kim SY
- KMID: 2432064
- Biomol Ther.
- 2019 Jan;27(1):34-40.
- doi: 10.4062/biomolther.2018.140
Transglutaminase 2 (TGase 2) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma. We found that microtubule-associated protein 1A/1B-light chain 3 (LC3),... -
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- Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation
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Lee JS, Kim SR, Song JH, Lee YP, Ko HJ
- KMID: 2431676
- Osong Public Health Res Perspect.
- 2018 Dec;9(6):334-339.
- doi: 10.24171/j.phrp.2018.9.6.07
OBJECTIVES: Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this... -
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- The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth via triggering autophagy
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Lv Y, Li B, Han K, Xiao Y, Yu X, Ma Y, Jiao Z, Gao J
- KMID: 2430084
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):617-625.
- doi: 10.4196/kjpp.2018.22.6.617
Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the... -
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- ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages
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Shrestha A, Pun NT, Park PH
- KMID: 2421722
- Biomol Ther.
- 2018 Sep;26(5):446-457.
- doi: 10.4062/biomolther.2018.078
Adiponectin, a hormone predominantly originated from adipose tissue, has exhibited potent anti-inflammatory properties. Accumulating evidence suggests that autophagy induction plays a crucial role in anti-inflammatory responses by adiponectin. However, underlying... -
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