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New Insights into Calorie Restriction Induced Bone Loss

Liu L, Rosen CJ

Caloric restriction (CR) is now a popular lifestyle choice due to its ability in experimental animals to improve lifespan, reduce body weight, and lessen oxidative stress. However, more and more...
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Beneficial effects of intermittent fasting: a narrative review

Song DK, Kim YW

Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily...
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Updated Meta-Analysis of Studies from 2011 to 2021 Comparing the Effectiveness of Intermittent Energy Restriction and Continuous Energy Restriction

Kim KK, Kang JH, Kim EM

Background: Despite the considerable number of trials and meta-analyses of studies on intermittent energy restriction (IER), it is not preferred to continuous energy restriction (CER) by the majority of obesity...
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Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy

Vidoni C, Ferraresi A, Esposito A, Maheshwari 1 C, Dhanasekaran DN, Mollace V, Isidoro C

Cancer is one of the most frequently diagnosed diseases, and despite the continuous efforts in searching for new and more effective treatments, its morbidity and mortality remain a significant health...
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The Discovery of Druggable Anti-aging Agents

Yalcin G, Lee CK

Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and...
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The Effects of Meal Timing and Frequency, Caloric Restriction, and Fasting on Cardiovascular Health: an Overview

Maugeri A, Vinciguerra M

Cardiovascular disease (CVD), which is the leading cause of death worldwide, is strongly affected by diet. Diet can affect CVD directly by modulating the composition of vascular plaques, and indirectly...
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Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice

Park KA, Jin Z, An HS, Lee JY, Jeong EA, Choi EB, Kim KE, Shin HJ, Lee JE, Roh GS

Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects...
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Preoperative Nutritional Management of Patients with Morbid Obesity

Hong J, Park S

Since patients with morbid obesity undergoing bariatric surgery are vulnerable to micronutrient deficiencies, close monitoring and supplementation are necessary. The importance of screening prior to surgery has increased in recent...
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A Multi-stage Carcinogenesis Model to Investigate Caloric Restriction as a Potential Tool for Post-irradiation Mitigation of Cancer Risk

Tani S, Blyth BJ, Shang Y, Morioka T, Kakinuma S, Shimada Y

The risk of radiation-induced cancer adds to anxiety in low-dose exposed populations. Safe and effective lifestyle changes which can help mitigate excess cancer risk might provide exposed individuals the opportunity...
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Six-week Diet Correction for Body Weight Reduction and Its Subsequent Changes of Gut Microbiota: A Case Report

Oh B, Kim JS, Kweon M, Kim BS, Huh IS

Impact of intestinal microbes on obesity and health is a new topic recently started to get attention. Comparing to the global concern and research trends, there are few research on...
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Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy

Kume S, Koya D

Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is increasing worldwide. The most effective treatment strategy for the condition is intensive treatment to strictly...
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Decreased Intermuscular Adipose Tissue due to Caloric Restriction in Obese Korean Women

Park JS, Lee HO, Kim YS, Yim JE

BACKGROUND: This study investigated the effects of caloric restriction on thigh intermuscular adipose tissue (IMAT) and the associations of IMAT and metabolic risk factors. METHODS: Thirty-three obese Korean women (BMI 27.2+/-2.5...
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Short-Term Caloric Restriction Does Not Reduce Bone Mineral Density in Rats with Early Type 2 Diabetes

Jeon YK, Kim WJ, Shin MJ, Chung HY, Kim SS, Kim BH, Kim SJ, Kim YK, Kim IJ

BACKGROUND: The effect of caloric restriction (CR) in the setting of diabetes on bone metabolism has not yet been fully studied. The aim of this study is to determine if...
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Intermittent Fasting in Diabetic Patients

Cho DH

Obesity is becoming increasingly prevalent worldwide. It is linked to health problems including cardiovascular disease, diabetes, cancer, musculoskeletal problems and even psychiatric problems. Intermittent fasting is an interventional strategy wherein...
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Effects of age on changes of body composition through caloric restriction in overweight and obese women

Yim JE, Kim YS, Choue R

  • KMID: 2327121
  • J Nutr Health.
  • 2013 Oct;46(5):410-417.
Caloric restriction is recognized as one of the best treatment options for obesity, and is associated with changes in body composition. The purpose of this study was to determine the...
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The Interplay between Autophagy and Aging

Pyo JO, Yoo SM, Jung YK

Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various...
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SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential

Kitada M, Koya D

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard...
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The association between measurement sites of visceral adipose tissue and cardiovascular risk factors after caloric restriction in obese Korean women

Lee HO, Yim JE, Lee JS, Kim YS, Choue R

  • KMID: 2313648
  • Nutr Res Pract.
  • 2013 Feb;7(1):43-48.
Quantities as well as distributions of adipose tissue (AT) are significantly related to cardiovascular disease (CVD) risk factors and can be altered with caloric restriction. This study investigated which cross-sectional...
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Sirt1 as a New Therapeutic Target in Metabolic and Age-Related Diseases

Lee DH

Sirt1 among the mammalian sirtuins has generated intense scientific interest in recent years, mainly because of its effects on longevity, metabolism, and other aging-related processes. Via nicotinamide adenine dinucleotide (NAD)-dependent...
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The Effects of Low-Calorie Diets on Abdominal Visceral Fat, Muscle Mass, and Dietary Quality in Obese Type 2 Diabetic Subjects

Ahn HJ, Cho YO, Kwon HR, Ku YH, Koo BK, Han KA, Min KW

BACKGROUND: Weight loss through low-calorie diets (LCDs) decreases visceral fat (VF). However, the effects on muscle mass, changes of dietary quality, and insulin sensitivity are unknown for Korean obese type...
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