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Bilateral Triple-Negative Invasive Breast Cancer with a BRCA2 Mutation, and Glioblastoma: A Case Report and Literature Review

Raufi A, Alsharedi , Khelfa Y, Tirona M

Breast cancer is the second leading cause of death among women in North America. Glioblastoma is the most common primary malignant central nervous system tumor in adults. The majority of...
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Molecular Classification of Triple-Negative Breast Cancer

Ahn SG, Kim SJ, Kim C, Jeong J

Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the...
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Treatment Outcomes of Weakly Positive Hormone Receptor Breast Cancer and Triple-Negative Breast Cancer

Yoon MR, Rhu JY, Song BJ, Chae BJ, Yoo TK

PURPOSE: In breast cancer, response to endocrine therapy depends on estrogen receptor and progesterone receptor status. However, poor prognosis is conferred on patients with hormone receptor (HR)-positive breast cancer. We...
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Identification of ERBB Pathway-Activated Cells in Triple-Negative Breast Cancer

Cho SY

Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast...
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The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge

Temian DC, Pop LA, Irimie AI, Berindan-Neagoe I

Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number...
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Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases

Kim M, Kim M, Chung YR, Park SY

Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in...
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Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer

Ahn SG, Jeong J, Hong S, Jung WH

With the advance in personalized therapeutic strategies in patients with breast cancer, there is an increasing need for biomarker-guided therapy. Although the immunogenicity of breast cancer has not been strongly...
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Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma

Kim H, Cho J, Kwon SY, Kang SH

PURPOSE: Nodal infiltration has been one of the most important prognostic factors in breast cancer. In recent decades, risk stratification has greatly changed, and is applied in accordance with hormone...
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Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin

Abdel Azim H, Kassem L, Shohdy KS, Eshaak B, Anis SE, Kamal NS

The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the...
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Druggable Molecular Targets for the Treatment of Triple Negative Breast Cancer

Nakhjavani M, Hardingham JE, Palethorpe HM, Price TJ, Townsend A

Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient expression of estrogen, progesterone,...
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Salivary Duct Cancer Metastasis Mimicking Primary Breast Cancer: A Case Report and Review

Alzuhair A, Gong G, Shin HJ, Lee JW, Lee SB, Kim J, Ko BS, Son BH, Ahn SH, Chung IY

Secondary breast malignancy is a rare occurrence, accounting for less than 2% of all breast malignancies. Salivary duct carcinoma (SDC) metastasizing to the breast has not been reported previously. This...
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miR-205 and miR-200c: Predictive Micro RNAs for Lymph Node Metastasis in Triple Negative Breast Cancer

Berber U, Yilmaz I, Narli G, Haholu A, Kucukodaci Z, Demirel D

  • KMID: 2353069
  • J Breast Cancer.
  • 2014 Jun;17(2):143-148.
PURPOSE: We examined expression profiles of 16 micro RNAs (miRNAs) in triple negative breast cancers to identify their potential as biomarkers for lymph node metastasis. METHODS: The expression profiles of miR-9,...
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Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data

Jung HC, Kim SH, Lee JH, Kim JH, Han SW

PURPOSE: To better identify the physiology of triple-negative breast neoplasm (TNBN), we analyzed the TNBN gene regulatory network using gene expression data. METHODS: We collected TNBN gene expression data from The...
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Triple-negative breast cancer that progressed as estrogen receptor-positive skin metastases

Lee SM, Kang EJ, Kim JH, Yun JM, Sun DS, Ko YH, Won HS

No abstract available.
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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

Nguyen LT, Lee YH, Sharma AR, Park JB, Jagga S, Sharma G, Lee SS, Nam JS

Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin...
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Evaluation of the Survival Benefit of Different Chemotherapy Regimens in Patients with T1-2N0 Triple-Negative Breast Cancer

Kim HA, Seong MK, Kim EK, Kang E, Park S, Hur MH, Song BJ, Noh WC, Korea Breast Cancer Society

PURPOSE: This study aimed to evaluate the survival benefit of different adjuvant chemotherapy regimens in patients with T1-2N0 triple-negative breast cancer. METHODS: Of 67,321 patients who were registered in the Korean...
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Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells

Lee HM, Moon A

Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor...
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In vivo validation of metastasis-regulating microRNA-766 in human triple-negative breast cancer cells

Oh K, Lee DS

Breast cancer is the second most common cancer and the most frequent cancer in women worldwide. Recent improvements in early detection and effective adjuvant chemotherapies have improved the survival of...
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Comparisons of Oncologic Outcomes between Triple-Negative Breast Cancer (TNBC) and Non-TNBC among Patients Treated with Breast-Conserving Therapy

Kim S, Park HS, Kim JY, Ryu J, Park S, Kim SI

PURPOSE: The optimum local surgical strategy regarding breast-conserving therapy (BCT) for triple-negative breast cancer (TNBC) is controversial. To investigate whether BCT is appropriate for patients with TNBC, we evaluated the...
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High Survivin and Low Zinc Finger of the Cerebellum 1 Expression Indicates Poor Prognosis in Triple-negative Breast Carcinoma

Shi CT, Ma J, Shi QF, Zhang Y, Wang HN

PURPOSE: Triple-negative breast carcinoma (TNBC) is accompanied with high risk of metastasis and recurrence. The present study aimed to explore the clinicopathological and prognostic roles of putative tumor-related genes in...
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