J Breast Cancer.  2016 Sep;19(3):223-230. 10.4048/jbc.2016.19.3.223.

Molecular Classification of Triple-Negative Breast Cancer

• Ahn SG
• Kim SJ
• Kim C
• Jeong J

• KMID: 2413946
• DOI: http://doi.org/10.4048/jbc.2016.19.3.223

Abstract

Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized issue in research area. Accordingly, recent studies have been successful in classifying TNBC into several distinct subtypes with specific biologic pathways. Despite the different methodologies used and varied number of final subtypes, these studies identically suggested that TNBC consists of four major subtypes: basal-like, mesenchymal, luminal androgen receptor, and immune-enriched. By reviewing these methods of classifications of TNBC, we highlight the unmet need to develop a molecular classifier suited for TNBC.

Keyword

Breast neoplasms; Gene expression; Triple negative breast neoplasms

MeSH Terms

Breast Neoplasms
Classification*
Gene Expression
Phenobarbital
Population Characteristics
Receptors, Androgen
Triple Negative Breast Neoplasms*
Phenobarbital
Receptors, Androgen

Figure

• 

  Figure 1 Distributions of the Vanderbilt subtypes using TNBCtype in Korean women with triple-negative breast cancer (n=45).

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