- SH3BP4, a novel pigmentation gene, is inversely regulated by miR-125b and MITF
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Kim KH, Lee TR, Cho EG
- KMID: 2389295
- Exp Mol Med.
- 2017 Aug;49(8):e367.
- doi: 10.1038/emm.2017.115
Our previous work has identified miR-125b as a negative regulator of melanogenesis. However, the specific melanogenesis-related genes targeted by this miRNA had not been identified. In this study, we established... -
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- Changes in Expressions of Endothelin-1, Microphthalmia Associated Transcription Factor, and Protease-activated Receptor-2 after Ultraviolet Irradiation
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Kim WS, Cho KM, Cho MK, Whang KU
- KMID: 2302761
- Korean J Dermatol.
- 2004 Nov;42(11):1419-1424.
BACKGROUND: A number of cytokines, growth factors and inflammatory mediators made by keratinocytes, fibroblasts and potentially other cells in the skin were shown to augment melanin production and/or melanin transfer... -
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- Whitening Effects of Marine Pseudomonas Extract
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Kang HY, Yoon TJ, Lee GJ
- KMID: 2156654
- Ann Dermatol.
- 2011 May;23(2):144-149.
- doi: 10.5021/ad.2011.23.2.144
BACKGROUND: Bacteria associated with marine invertebrates are a rich source of bioactive metabolites. OBJECTIVE: The effects of marine bacteria extracts on pigmentation were investigated to find novel whitening agents. METHODS: The marine... -
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- Effect of MITF-M and MITF-A Overexpression on the Dendrtic Formation in Melanocytes
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Jo IS, Sohn KC, Kim CD, Lee YH
- KMID: 2161138
- Korean J Phys Anthropol.
- 2016 Mar;29(1):27-34.
- doi: 10.11637/kjpa.2016.29.1.27
The microphthalmia-associated transcription factor (MITF), has been described as the master regulator of the basic helix-loop-helix leucine zipper family, involves melanogenesis in melanocytes. MITF consists of at least six isoforms,... -
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- ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
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Song YS, Balcos MC, Yun HY, Baek KJ, Kwon NS, Kim MK, Kim DS
- KMID: 2071816
- Korean J Physiol Pharmacol.
- 2015 Jan;19(1):29-34.
- doi: 10.4196/kjpp.2015.19.1.29
Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible... -
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- Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway
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Ko GA, Kim Cho S
- KMID: 2398555
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):53-61.
- doi: 10.4196/kjpp.2018.22.1.53
Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent.... -
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- Pigmentation Effect of Electromagnetic Fields at Various Intensities to Melanocytes
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Cho SE, Kim YM, Kang KH, Kim SC, Park JK, Seo YK
- KMID: 2360805
- Tissue Eng Regen Med.
- 2016 Oct;13(5):560-567.
- doi: 10.1007/s13770-016-0090-2
Melanogenesis is the biological process that results in the synthesis of skin pigment of melanin and it has various functions in living systems and is synthesized by the melanosome within... -
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- Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes
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Lim HS, Jin S, Yun SJ
- KMID: 2152655
- Chonnam Med J.
- 2016 Jan;52(1):45-52.
- doi: 10.4068/cmj.2016.52.1.45
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and... -
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- Scopoletin from Cirsium setidens Increases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells
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Ahn MJ, Hur SJ, Kim EH, Lee SH, Shin JS, Kim MK, Uchizono J, Whang WK, Kim DS
- KMID: 2285524
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):307-311.
- doi: 10.4196/kjpp.2014.18.4.307
In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effects on melanogenesis. Scopoletin was not toxic to cells at concentrations less than 50 microM and... -
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- Microarray Analysis of Gene Expression During Differentiation of Human Mesenchymal Stem Cells Treated with Vitamin E in vitro into Osteoblasts
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Ahn KH, Jung HK, Jung SE, Yi KW, Park HT, Shin JH, Kim YT, Hur JY, Kim SH, Kim T
- KMID: 2300157
- Korean J Bone Metab.
- 2011 May;18(1):23-32.
OBJECTIVE: Supplementation with vitamin E is able to protect bone against free radical-induced elevation of bone-resorbing cytokines. We examined gene expression by microarray analysis during the differentiation of human mesenchymal... -
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- Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase
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Lee HE, Kim EH, Choi HR, Sohn UD, Yun HY, Baek KJ, Kwon NS, Park KC, Kim DS
- KMID: 2011164
- Korean J Physiol Pharmacol.
- 2012 Aug;16(4):287-291.
- doi: 10.4196/kjpp.2012.16.4.287
This study investigated the effects of proline-serine (PS) and valine-serine (VS) dipeptides on melanogenesis in Mel-Ab cells. Proline-serine and VS significantly inhibited melanin synthesis in a concentration-dependent manner, though neither... -
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- Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro
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Xu P, Chen J, Tan C, Lai RS, Min ZS
- KMID: 2376956
- Korean J Physiol Pharmacol.
- 2017 May;21(3):287-292.
- doi: 10.4196/kjpp.2017.21.3.287
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle... -
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- Tranexamic Acid Diminishes Laser-Induced Melanogenesis
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Kim MS, Bang SH, Kim JH, Shin HJ, Choi JH, Chang SE
- KMID: 2352494
- Ann Dermatol.
- 2015 Jun;27(3):250-256.
- doi: 10.5021/ad.2015.27.3.250
BACKGROUND: The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging. Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated a curative effect towards melasma and ultraviolet-induced PIH in Asian countries. However,... -
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- Sageretia thea fruit extracts rich in methyl linoleate and methyl linolenate downregulate melanogenesis via the Akt/GSK3β signaling pathway
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Ko GA, Shrestha S, Kim Cho S
- KMID: 2429013
- Nutr Res Pract.
- 2018 Feb;12(1):3-12.
- doi: 10.4162/nrp.2018.12.1.3
BACKGROUND/OBJECTIVES: Sageretia thea is traditionally used as a medicinal herb to treat various diseases, including skin disorders, in China and Korea. This study evaluated the inhibitory effect of Sageretia thea... -
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- Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin
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Lee TH, Seo JO, Baek SH, Kim SY
- KMID: 2048328
- Biomol Ther.
- 2014 Jan;22(1):35-40.
Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits... -
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- KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model
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Li H, Kim J, Hahn HG, Yun J, Jeong HS, Yun HY, Baek KJ, Kwon NS, Min YS, Park KC, Kim DS
- KMID: 2285517
- Korean J Physiol Pharmacol.
- 2014 Jun;18(3):249-254.
- doi: 10.4196/kjpp.2014.18.3.249
The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action.... -
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- Artemisia capillaris Thunb. inhibits melanin synthesis activity via ERK-dependent MITF pathway in B16/F10 melanoma cells
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Saba E, Oh MJ, Lee YY, Kwak D, Kim S, Rhee MH
- KMID: 2437671
- Korean J Vet Res.
- 2018 Mar;58(1):1-7.
- doi: 10.14405/kjvr.2018.58.1.1
Genus Artemisia occurs as a hardy plant and has a wide range of culinary and medicinal features. In this study, we aimed to describe the melanin inhibitory activity of one... -
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- Clinicopathologic Features of Progressive Macular Hypomelanosis in Korea
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Lee HS, Sohn S, Kang HY, Lee ES, Kim YC
- KMID: 2246225
- Korean J Dermatol.
- 2015 Feb;53(2):113-118.
BACKGROUND: Progressive macular hypomelanosis, a disease of uncertain etiology, was first described by Guillet et al. in 1988. It is characterized by asymptomatic hypopigmented macules and patches that appear on... -
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- Anti-melanogenic effects of Hordeum vulgare L. barely sprout extract in murine B16F10 melanoma cells
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Choi JH, Jung JG, Kim JE, Bang MA
- KMID: 2444940
- J Nutr Health.
- 2019 Apr;52(2):168-175.
- doi: 10.4163/jnh.2019.52.2.168
PURPOSE: Barely sprout is a well-known oriental herbal medicine with a wide range of health benefits. Recent studies have provided scientific evidence of its therapeutic effects with expanded application. This... -
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- Induction of Melanogenesis by Rapamycin in Human MNT-1 Melanoma Cells
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Hah YS, Cho HY, Lim TY, Park DH, Kim HM, Yoon J, Kim JG, Kim CY, Yoon TJ
- KMID: 2434679
- Ann Dermatol.
- 2012 May;24(2):151-157.
BACKGROUND: Melanogenesis is one of the characteristic parameters of differentiation in melanocytes and melanoma cells. Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in... -
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