Korean J Dermatol.  2004 Nov;42(11):1419-1424.

Changes in Expressions of Endothelin-1, Microphthalmia Associated Transcription Factor, and Protease-activated Receptor-2 after Ultraviolet Irradiation

• Kim WS
• Cho KM
• Cho MK
• Whang KU

Abstract

BACKGROUND
A number of cytokines, growth factors and inflammatory mediators made by keratinocytes, fibroblasts and potentially other cells in the skin were shown to augment melanin production and/or melanin transfer to keratinocytes. A lot of studies were done to investigate the mechanisms. But there was no studies about sequential relationship between the suggestive factors. OBJECT: To measure the changes in expressions of ET-1, MITF, and PAR-2 after UV exposure on skin in Korean. MATERIAL AND METHOD: We established an immunohistochemical staining protocol for specimens which were obtained from UV-irradiated skin in four healthy Korean males on the 2nd, 4th, 7th days after UV irradiation. RESULT: This study reveals the sequential relationship between ET-1, MITF, and PAR-2. ET-1 was increased at day 2 and decreased at day 4 and 7. MITF increased gradually day 2, day 4, and day 7. PAR-2 increased at day 4 and increased once more at day 7.

Keyword

Melanocyte; Endothelin-1; MITF; Protease-activated receptor-2

MeSH Terms

Cytokines
Endothelin-1*
Fibroblasts
Humans
Intercellular Signaling Peptides and Proteins
Keratinocytes
Male
Melanins
Melanocytes
Microphthalmia-Associated Transcription Factor*
Microphthalmos*
Skin
Cytokines
Endothelin-1
Intercellular Signaling Peptides and Proteins
Melanins
Microphthalmia-Associated Transcription Factor