- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- A Case of Widespread Dermatophytosis during Interleukin-17A Inhibitor Treatment in Psoriasis Patient with Tinea Unguium
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Lee J, Na N, Park J
- KMID: 2470575
- Korean J Med Mycol.
- 2019 Dec;24(4):100-104.
- doi: 10.17966/JMI.2019.24.4.100
Interleukin-17 (IL-17) is secreted by a class of helper T cells called Th17 cells, which stimulates keratinocytes to secrete proinflammatory mediator and to recruit other inflammatory cells in psoriatic skins.... -
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- Feasibility of Cultured Allogenic Keratinocyte Treatment for Third Degree Burns
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Choi J, Cho JT, Choi JY, Seo BF, Jung SN
- KMID: 2469248
- J Korean Burn Soc.
- 2019 Dec;22(2):45-48.
- doi: 10.0000/jkbs.2019.22.2.45
Allogenic keratinocyte application is widely used for treatment of second degree burns. However, there is no significant body of report on application of allogenic keratinocyte to third degree burns. A... -
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- An Important Role of Macrophages for Wound Margin Regeneration in a Murine Flap Model
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Won HR, Seo C, Lee HY, Roh J, Kim CH, Jang JY, Shin YS
- KMID: 2467058
- Tissue Eng Regen Med.
- 2019 Dec;16(6):667-674.
- doi: 10.1007/s13770-019-00214-x
BACKGROUND: Macrophages have been known to have diverse roles either after tissue damage or during the wound healing process; however, their roles in flap wound healing are poorly understood. In... -
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- Wound Healing Potential of Low Temperature Plasma in Human Primary Epidermal Keratinocytes
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Cui HS, Cho YS, Joo SY, Mun CH, Seo CH, Kim JB
- KMID: 2467051
- Tissue Eng Regen Med.
- 2019 Dec;16(6):585-593.
- doi: 10.1007/s13770-019-00215-w
BACKGROUND: Low temperature plasma (LTP) was recently shown to be potentially useful for biomedical applications such as bleeding cessation, cancer treatment, and wound healing, among others. Keratinocytes are a major... -
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- Cutaneous squamous cell carcinoma: High risk factors, staging and management
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Park HJ
- KMID: 2466486
- Korean Lepr Bull.
- 2019 Dec;52(1):3-8.
- doi: 10.33161/klb.2019.52.1.3
Cutaneous squamous cell carconoma(cSCC) is a malignant neoplasm derived from suprabasal epidermal keratinocytes, which is one of the nonmelanoma skin cancers that represent the most common malignancies in humans. Although... -
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- A Novel Effect of Lipids Extracted from Vernix Caseosa on Regulation of Filaggrin Expression in Human Epidermal Keratinocytes
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Qiao W, Jia T, Gu H, Guo R, Kaku K, Wu W
- KMID: 2461983
- Ann Dermatol.
- 2019 Dec;31(6):611-620.
- doi: 10.5021/ad.2019.31.6.611
BACKGROUND: Vernix caseosa (VC), which is known as a unique human substance, is a biofilm that covers the skin of most human newborns. VC has many biological functions including anti-infective,... -
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- Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes
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Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS
- KMID: 2462884
- Biomol Ther.
- 2019 Nov;27(6):570-576.
- doi: 10.4062/biomolther.2019.025
Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can... -
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- Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
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Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW
- KMID: 2462883
- Biomol Ther.
- 2019 Nov;27(6):562-569.
- doi: 10.4062/biomolther.2019.061
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that... -
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- Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice
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Jeong H, Lim KM, Goldenring JR, Nam KT
- KMID: 2462882
- Biomol Ther.
- 2019 Nov;27(6):553-561.
- doi: 10.4062/biomolther.2019.125
Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast,... -
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- Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α
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Oh C, Kim HJ, Kim HM
- KMID: 2461018
- J Periodontal Implant Sci.
- 2019 Oct;49(5):270-286.
- doi: 10.5051/jpis.2019.49.5.270
PURPOSE: Despite the well-known anti-inflammatory effects of vitamin D in periodontal health, its mechanism has not been fully elucidated. In the present study, the effect of vitamin D on strengthening... -
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- Influence of traditional medicines on the activity of keratinocytes in wound healing: an in-vitro study
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Kotian SR, Bhat KM, Padma D, Pai KS
- KMID: 2459548
- Anat Cell Biol.
- 2019 Sep;52(3):324-332.
- doi: 10.5115/acb.19.009
Natural medicinal systems such as Ayurveda and folk medicine has remedies for wound management. However, the exact cellular and extracellular mechanisms involved in the healing process and its influence on... -
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- The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis
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Zmorzyński S, Styk W, Filip AA, Krasowska
- KMID: 2451472
- Ann Dermatol.
- 2019 Aug;31(4):365-371.
- doi: 10.5021/ad.2019.31.4.365
Systemic sclerosis (SSc) is an autoimmune disorder characterized by the fibrosis of skin, heart, lung, and kidney as well. Excessive activation of fibroblasts is associated with higher expression of Notch1... -
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- Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5
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Zhen AX, Piao MJ, Hyun YJ, Kang KA, Ryu YS, Cho SJ, Kang HK, Koh YS, Ahn MJ, Kim TH, Hyun JW
- KMID: 2455095
- Biomol Ther.
- 2019 Jul;27(4):395-403.
- doi: 10.4062/biomolther.2018.151
Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- Effect of apoptosis on G361 cells by Cimicifuga rhizoma extract
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Choi BB, Kim GC, Hong JW, Park SR
- KMID: 2456840
- J Korean Acad Oral Health.
- 2019 Jun;43(2):72-77.
- doi: 10.11149/jkaoh.2019.43.2.72
OBJECTIVES: To investigate whether the cytotoxic effect of Cimicifuga rhizoma extract is associated with cell death in the human keratinocyte (HaCaT) and human melanoma cell lines (G361). METHODS: Apoptosis induced by... -
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- Esculetin Prevents the Induction of Matrix Metalloproteinase-1 by Hydrogen Peroxide in Skin Keratinocytes
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Zhen AX, Piao MJ, Kang KA, Fernando P, Kang HK, Koh YS, Hyun JW
- KMID: 2454671
- J Cancer Prev.
- 2019 Jun;24(2):123-128.
- doi: 10.15430/JCP.2019.24.2.123
BACKGROUND: Reactive oxygen species (ROS) are involved in various cellular diseases. Excessive ROS can cause intracellular oxidative stress, resulting in a calcium imbalance and even aging. In this study, we... -
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- Adiponectin Promotes Caspase-14 Expression in Normal Human Epidermal Keratinocytes
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Choi SY, Kim MJ, Hong JY, Park KY, Seo SJ
- KMID: 2444875
- Ann Dermatol.
- 2019 Jun;31(3):352-355.
- doi: 10.5021/ad.2019.31.3.352
No abstract available. -
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- Inhibition of Poly(I:C)-Induced Inflammation by Salvianolic Acid A in Skin Keratinocytes
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Zhang QL, Jiang RH, Li XM, Ko JW, Kim CD, Zhu MJ, Lee JH
- KMID: 2444859
- Ann Dermatol.
- 2019 Jun;31(3):279-285.
- doi: 10.5021/ad.2019.31.3.279
BACKGROUND: Skin keratinocytes participate actively in inducing immune responses when external pathogens are introduced, thereby contributing to elimination of pathogens. However, in condition where the excessive inflammation is occurred, chronic... -
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- Therapeutic Effects of Synthetic Antimicrobial Peptides, TRAIL and NRP1 Blocking Peptides in Psoriatic Keratinocytes
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Ryu S, Broussard , Youn C, Song B, Norris D, Armstrong , Kim B, Song PI
- KMID: 2447209
- Chonnam Med J.
- 2019 May;55(2):75-85.
- doi: 10.4068/cmj.2019.55.2.75
Psoriasis is a chronic, recurrent, heterogeneous, cutaneous inflammatory skin disease for which there is no cure. It affects approximately 7.5 million people in the United States. Currently, several biologic agents... -
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