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NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria

Wu Cz, Li X, Hong L, Han Zn, Liu Y, Wei Cx, Cui X

Nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are the major enzymatic source of reactive oxygen species (ROS). NOX2 and NOX4 are expressed in the heart but its role in hypoxia-induced atrial...
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Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study

Stasi C, Bellini M, Gambaccini D, Duranti E, de Bortoli N, Fani B, Albano E, Russo S, Sudano I, Laffi G, Taddei S, Marchi S, Bruno RM

  • KMID: 2387834
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):428-434.
  • doi: 10.5056/jnm16155
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a multifactorial disorder, involving dysregulation of brain-gut axis. Our aim was to evaluate the neuroendocrine activity in IBS. METHODS: Thirty IBS and 30 healthy volunteers...
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cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

Peng LQ, Li P, Zhang QL, Hong L, Liu LP, Cui X, Cui BR

Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na(+)-K(+)-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase...
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Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial

Shin S, Kim KJ, Cho IJ, Hong GR, Jang Y, Chung N, Rah YM, Chang HJ

PURPOSE: Primary vascular dysregulation (PVD) is a condition in which the response to cold temperature or external stimuli is abnormal. We investigated whether triflusal use results in amelioration of PVD...
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Urine endothelin-1 as a Biomarker for Urinary Tract Infections in Children

Kee HM, Yi DY, Yun KW, Lim IS

  • KMID: 2196567
  • J Korean Soc Pediatr Nephrol.
  • 2014 Apr;18(1):36-41.
PURPOSE: Urinary tract infections (UTIs) are the most common source of bacterial infections in infants and young children. Accurate diagnosis and treatment is important because of their association with renal...
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Role of Urinary Levels of Endothelin-1, Monocyte Chemotactic Peptide-1, and N-Acetyl Glucosaminidase in Predicting the Severity of Obstruction in Hydronephrotic Neonates

Mohammadjafari H, Rafiei A, Mousavi SA, Alaee A, Yeganeh Y

PURPOSE: Antenatal hydronephrosis (AH) is found in 0.5%-1% of neonates. The aim of the study was to assess the urinary concentrations of 3 biomarkers, endothelin-1 (ET-1), monocyte chemotactic peptide-1 (MCP-1),...
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Expression Changes of Endothelin-1, Endothelin Receptor A and B in the Cochlea after Noise Exposure

Hur GM, Lyu AR, Han WK, Choi JW, Rha KS, Park YH

BACKGROUND AND OBJECTIVES: There are several evidences of reduced cochlea blood flow after noise exposure in the cochlea. However, the pathophysiology of blood flow change is still obscure, and endothelins,...
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Changes of Endothelin-1 in Rats Corpus Cavernosum Smooth Muscle of Partial Bladder Outlet Obstruction

Kim KH, Seo YJ, Lee KS

PURPOSE: Lower urinary tract symptoms and erectile dysfunction (ED) are common disorders in men and increase with age. Recently, there has been evidence to suggest that patients with high benign...
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Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?

Lim CH, Shin HK, Kang WH, Jeong SK, Yang HK

PURPOSE: Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is...
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A Case of Sustained Severe Pulmonary Hypertension after Sugrical Repair of Atrial Septal Defect in a Patient with HIV Infection

Kim WS, Park SH, Choi HJ, Han JJ

  • KMID: 1457279
  • J Korean Soc Hypertens.
  • 2010 Sep;16(3):35-40.
We report a case of severe pulmonary hypertension in a patient with human immunodeficiency virus(HIV) infection. A 29-year-old woman with asymptomatic HIV infection was diagnosed as atrial septal defect(ASD) and...
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Effect of Stimulation Intensity and Location of Cerebral Infarction on Motor Evoked Potentials in the Rat

Chae SH, Kwon HC, Hyun JK, Kim TU, Lee YI, Lee SJ

  • KMID: 2326069
  • J Korean Acad Rehabil Med.
  • 2010 Aug;34(4):381-386.
OBJECTIVE: To investigate the change of motor evoked potential (MEP) in the cerebral infarction, and observe the effect of stimulation intensity and location of cerebral infarction, using rat model of...
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Ezrin and Endothelin-1 Expression in Dermatofibroma and Dermatofibrosarcoma Protuberans

Youn SH, Choi WJ, Cho EB, Park HR, Park EJ, Kwon IH, Kim KH, Kim KJ

  • KMID: 2301847
  • Korean J Dermatol.
  • 2010 Aug;48(8):678-683.
BACKGROUND: Distinction of dermatofibroma (DF) from dermatofibrosarcoma protuberans (DFSP) is occasionally difficult. Histologically, DF shows fibrohistiocyte growth, and DFSP shows myofibroblast proliferation. This difference is usually targeted by several immunohistochemical...
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Analysis of Systemic Factors through Blood Examination in Normal-Tension Glaucoma Patients

Lee NY, Ahn MD

PURPOSE: In this study, we evaluated systemic hemodynamic factors of normal tension glaucoma. METHODS: Forty patients with normal tension glaucoma and thirty healthy people were investigated with regard to hemoglobin, hematocrit,...
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The Role of Endothelin-1 in Obstructive Sleep Apnea Syndrome and Pulmonary Hypertension

Choi Y

  • KMID: 2317493
  • Sleep Med Psychophysiol.
  • 2010 Dec;17(2):69-74.
Obstructive sleep apnea syndrome is associated with significant cardiovascular morbidity and increased mortality. However, it was controversial whether obstructive sleep apnea syndrome could cause pulmonary hypertension. The controversy was resolved...
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Plasma C-Reactive Protein and Endothelin-1 Level in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension

Kwon YS, Chi SY, Shin HJ, Kim EY, Yoon BK, Ban HJ, Oh IJ, Kim KS, Kim YC, Lim SC

Pulmonary hypertension is a frequent complication of chronic obstructive pulmonary disease (COPD) and associated with a worse survival and increased risk of hospitalization for exacerbation of COPD. However, little information...
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Expression of Endothelin-1 by Stimulation with CXCL8 in Mouse Peritoneal Macrophages

Bae JJ, Kim JH, Kim H, Kim HS

Endothelin-1 (ET-1) has been characterized as a potent vasoconstrictor secreted by the endothelium, and play a major role in the regulation of vascular tone. It has been also known to...
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Changes in Evoked Potentials in Focal Cerebral Cortical Ischemia in the Rat

Lee SJ, Park WB, Chae S, Lee YI, Kim TU

  • KMID: 2325319
  • J Korean Acad Rehabil Med.
  • 2009 Apr;33(2):147-153.
OBJECTIVE: To investigate the changes of motor and somatosensory evoked potentials found in focal cerebral cortical ischemia induced by endothelin-1 (ET-1), one of the common models of cerebral infarct in...
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No association between endothelin-1 gene polymorphisms and preeclampsia in Korean population

Kim SY, Park SY, Lim JH, Yang JH, Kim MY, Park HY, Lee KS, Ryu HM

  • KMID: 2184445
  • J Genet Med.
  • 2008 Jun;5(1):34-40.
PURPOSE: Preeclampsia is a major cause of maternal and perinatal mortality and morbidity and is considered to be a multifactorial disorder involving a genetic predisposition and environmental factors. Endothelin-1 (ET-1)...
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Effects of Rosiglitazone on Heat Shock Protein and the Endothelin System in Deoxycorticosterone Acetate-Salt Hypertensive Rats

Bae EH, Kim IJ, Park JW, Ma SK, Choi KC, Lee JU, Kim SW

The deoxycorticosterone acetate (DOCA)-salt rat is known as a model of volume dependent hypertension and characterized by increased cardiac endothelin-1 (ET-1) content. Recently, it has been reported that rosiglitazone (RGT),...
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Changes in Corpus Cavernosum after Partial Bladder Outlet Obstruction in Rat

Mo KI, Lee HI, Lee KS

  • KMID: 2312021
  • Korean J Urol.
  • 2008 Feb;49(2):160-167.
PURPOSE: Abnormalities of the relaxation and contraction of the corpus cavernosum can lead to erectile dysfunction. Therefore, we induced a partial bladder outlet obstruction(PBOO) in male rats, and investigated the...
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