Biomol Ther.  2014 Jan;22(1):27-34.

Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

Affiliations
  • 1College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea. hwchang@yu.ac.kr seungho@yumail.ac.kr
  • 2School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Abstract

Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular Ca2+ influx via phospholipase Cgamma1 (PLCgamma1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappaB (NF-kappaB) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum LTC4, PGD2, and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.

Keyword

Curcumin; Mast cell; Prostaglandin D2; Leukotriene C4; Mitogen activated protein kinase; Passive systemic anaphylaxis

MeSH Terms

Administration, Oral
Anaphylaxis*
Animals
Arachidonate 5-Lipoxygenase
Curcuma
Curcumin*
Cyclooxygenase 2
Histamine*
Immunoglobulin E
Immunoglobulins*
Leukotriene C4
Mast Cells*
Mice*
Mitogen-Activated Protein Kinases
Phospholipases
Phosphorylation
Prostaglandin D2
Arachidonate 5-Lipoxygenase
Curcumin
Cyclooxygenase 2
Histamine
Immunoglobulin E
Immunoglobulins
Leukotriene C4
Mitogen-Activated Protein Kinases
Phospholipases
Prostaglandin D2
Full Text Links
  • BT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr