- Role of Prostaglandin D2 in the Pathogenesis of Asthma
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- KMID: 2299463
- Korean J Asthma Allergy Clin Immunol.
- 2012 Sep;32(3):144-149.
Prostaglandin D2 is a major lipid mediator released from activated mast cells of which metabolite 9alpha,11beta-prostaglandin F2 are used as a biomarker of mast cell activation in various type of... -
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- Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
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Arima M, Fukuda T
- KMID: 1036144
- Korean J Intern Med.
- 2011 Mar;26(1):8-18.
- doi: 10.3904/kjim.2011.26.1.8
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be... -
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- The Influence of IgE on Cultured Human Mast Cells
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Frandsen P, Krohn IJ, Hoffmann H, Schiotz PO
- KMID: 2260286
- Allergy Asthma Immunol Res.
- 2013 Nov;5(6):409-414.
- doi: 10.4168/aair.2013.5.6.409
PURPOSE: The mast cell plays a pivotal role in the human immune response. Crosslinking of 2 IgE molecules bound to the high affinity IgE receptor (FcepsilonRI) on the surface of... -
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- Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells
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Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E
- KMID: 2380290
- Biomol Ther.
- 2015 Sep;23(5):421-427.
- doi: 10.4062/biomolther.2015.023
Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse... -
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- Effect of prostaglandins D2, E2 and I2 on the regulation of KATP channel activity in rat cardiac myocytes
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Ju JM, Nah SY, Kim JH
- KMID: 2071552
- Korean J Physiol Pharmacol.
- 1999 Oct;3(5):507-512.
Contribution of prostaglandins D2, E2 and I2 (PGD2, PGE2 and PGI2) on the regulation of ATP-sensitive K+ channel (KATP channel) was investigated in isolated single rat ventricular cardiac myocytes using the patch clamp... -
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- Heat contact urticaria: a case report
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Chung HS, Lee KH, Ro JY
- KMID: 699897
- Yonsei Med J.
- 1996 Jun;37(3):230-235.
- doi: 10.3349/ymj.1996.37.3.230
Heat contact urticaria is very rare and it is characterized by the development of wheal limited to the areas of heat contact. We report a case of heat contact urticaria... -
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- Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels
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Li X, Lu Y, Jin Y, Son JK, Lee SH, Chang HW
- KMID: 2048327
- Biomol Ther.
- 2014 Jan;22(1):27-34.
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its... -
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- Hair growth promoting effects of emodin in telogenic C57BL/6 mice
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Yon JM, Park SG, Lin C, Gwon LW, Lee JG, Baek IJ, Lee BJ, Yun YW, Nam SY
- KMID: 2368750
- Korean J Vet Res.
- 2016 Jun;56(2):97-101.
- doi: 10.14405/kjvr.2016.56.2.97
Emodin is an anthraquinone derivative from the roots of Rheum officinale Baill that possesses a variety of biological activities, including inhibition of 5α-reductase and prostaglandin D2. In this study, we... -
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- Mast Cells and Allergic Rhinitis
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Cho JS
- KMID: 2297727
- J Rhinol.
- 1998 Nov;5(2):85-91.
That mast cells play a role in acute allergic inflammation by releasing various inflammatory mediators, including histamine, leukotrienes (LT), such as LTC4 and LTD4, and prostaglandins (PG), such as PGD2,... -
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- HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices: Involvement of the ERK1/2 Signaling Pathway
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Lee EO, Yang JH, Kim JH, Woo SY, Chong YH
- KMID: 1782702
- J Bacteriol Virol.
- 2013 Mar;43(1):45-53.
- doi: 10.4167/jbv.2013.43.1.45
15-deoxy-delta12,14 prostaglandin J2 (15d-PGJ2) may hold promise in treatment of the pathologies associated with human immunodeficiency virus (HIV) infection of the central nervous system. However, its precise role and neuroprotective... -
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- Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cells
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Lim JH, Woo CH
- KMID: 1447440
- Anat Cell Biol.
- 2011 Dec;44(4):265-273.
- doi: 10.5115/acb.2011.44.4.265
Atherosclerosis is readily observed in areas where disturbed flow is formed, while the atheroprotective region is found in areas with steady laminar flow (L-flow). It has been established that L-flow... -
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- Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
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Lu Y, Li X, Park YN, Kwon O, Piao D, Chang YC, Kim CH, Lee E, Son JK, Chang HW
- KMID: 2170636
- Biomol Ther.
- 2014 May;22(3):193-199.
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells.... -
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- The Macrophage-Specific Transcription Factor Can Be Modified Posttranslationally by Ubiquitination in the Lipopolysaccharide-Treated Macrophages
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Jung JW, Choi JC, Kim JY, Park IW, Choi BW, Shin JW, Christman
- KMID: 1442860
- Tuberc Respir Dis.
- 2011 Feb;70(2):113-124.
- doi: 10.4046/trd.2011.70.2.113
BACKGROUND: Macrophages are one of the most important inflammatory cells in innate immunity. PU.1 is a macrophage-specific transcription factor. Ubiquitins are the ultimate regulator of eukaryotic transcription. The ubiquitination process... -
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- 15-Deoxy-Delta(12,14)-Prostaglandin J2 and Proinflammatory Cytokines in IgA Nephropathy
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Jeong YS, Song SH, Lee DW, Lee SB, Yang BY, Kwak IS
- KMID: 2253266
- Korean J Nephrol.
- 2008 May;27(3):307-318.
PURPOSE: This study was performed to demonstrate a correlation among urinary 15d-PGJ2, proinflammatory cytokines (i.e. IL-23, IL-6, and TGF-beta1), and CRP, and to determinate the contributors to prognostic score and... -
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- Identification of Gene Expression Signatures in Korean Acute Leukemia Patients
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Lee KH, Park SW, Kim I, Yoon SS, Park S, Kim BK
- KMID: 1512143
- Genomics Inform.
- 2006 Sep;4(3):97-102.
BACKGROUND: In acute leukemia patients, several successful methods of expression profiling have been used for various purposes, i.e., to identify new disease class, to select a therapeutic target, or to... -
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- 15-Deoxy-Delta(12,14)-Prostaglandin J2 Upregulates the Expression of LPS-Induced IL-8/CXCL8 mRNA in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats
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Kim JH, Kim HS
- KMID: 1474597
- Immune Netw.
- 2009 Apr;9(2):64-73.
- doi: 10.4110/in.2009.9.2.64
BACKGROUND: 15d-PGJ2 has been known to act as an anti-inflammatory agent and has anti-hypertensive effects. As a result of these properties, we examined the effect of 15d-PGJ2 on the LPS-induced... -
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- Regulation of Guanine Nucleotide Binding Protein Activity in Normal Rat Pancreatic Islet Secretory Granule by Arachidonic Acid and its Metabolites
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Sung YA
- KMID: 2331717
- J Korean Diabetes Assoc.
- 1999 Apr;23(2):120-130.
BACKGROUND: Arachidonic acid (AA) generated by the activation of phospholipase A2. and 12hydroxyeicasateraenoic acid (12-HEIE), a lipoxygenase metabolite of AA stimulates glucose induced insulin secretion in pancreatic islets, whereas prostaglandin... -
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- The effect of rhBMP-2 on delta12-PGJ2 induced osteoblastic differentiation and mineralization
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Kim WK, Kim KH, Kim JJ, Lee YK, Ku Y
- KMID: 1999763
- J Korean Acad Periodontol.
- 2005 Jun;35(2):345-357.
- doi: 10.5051/jkape.2005.35.2.345
Prostaglandin plays a significant role in the local control of bone metabolism associated with periodontal disease. delta12-PGJ2 is a natural PGD2 metabolite that is formed in vivo in the presence... -
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- Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A2 and 12-PGJ2.
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Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim HS, Shim JY, Kim JW, Lee JH, Kim IK
- KMID: 1380233
- Exp Mol Med.
- 2002 Jul;34(3):243-249.
We reported earlier that expression of Sox-4 was found to be elevated during prostaglandin (PG) A2 and delta(12)-PGJ(12) induced apoptosis in human hepatocarcinoma Hep3B cells. In this study, the role... -
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- Antineoplastic effect of endogenous peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta(12,14)-prostaglandin J2, on cholangiocarcinoma cells
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Jung SH, Kim BH, Kim YI, Shim J, Hwangbo Y, Jang JY, Dong SH, Kim HJ, Chang YW, Chang R, Kim DG
- KMID: 2259206
- Korean J Med.
- 2010 Jan;78(1):75-86.
BACKGROUND/AIMS: Peroxisome proliferator-activated receptor (PPAR)-gamma ligand is known to inhibit the growth of several kinds of cancer cells, yet its effect on cholangiocarcinoma is indecisive. We investigated the effect of... -
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