Korean J Nephrol.  2008 May;27(3):307-318.

15-Deoxy-Delta(12,14)-Prostaglandin J2 and Proinflammatory Cytokines in IgA Nephropathy

• Jeong YS
• Song SH
• Lee DW
• Lee SB
• Yang BY
• Kwak IS

Abstract

PURPOSE: This study was performed to demonstrate a correlation among urinary 15d-PGJ2, proinflammatory cytokines (i.e. IL-23, IL-6, and TGF-beta1), and CRP, and to determinate the contributors to prognostic score and proteinuria in IgAN patients.
METHODS
Fifty-four patients with biopsy-proven IgAN were enrolled. For comparison with IgAN, five MCD patients were also enrolled. Immunohistochemical staining for PPAR-gamma in kidney tissue and measurements of urinary IL-6, IL-23, TGF-beta1, 15d-PGJ2 and serum CRP were performed
RESULTS
There was no difference according to PPAR-gamma staining. 15d-PGJ2 was negatively correlated with urinary IL-23, TGF-beta1, and CRP. Among proinflammatory cytokines and CRP, there were positive relationships with each other except for IL-23 and CRP. TGF-beta1 in the group having proteinuria more than 3 g/day was statistically higher than that in the sole hematuria group. However, in multivariate regression analysis, not a single relation was found between TGF-beta1 and proteinuria. Prognostic score was correlated with IL-6, IL-23, TGF-beta1, CRP, 15d-PGJ2, and 24hr proteinuria. 24hr proteinuria was correlated with IL-6 and 15d-PGJ2. In multivariate regression analysis, CRP, 15d-PGJ2, and 24hr proteinuria contributed to prognostic score, and only 15d-PGJ2 contributed to 24hr proteinuria. Last, urinary 15d-PGJ2 in IgAN was higher than that in MCD.
CONCLUSION
Endogenous 15d-PGJ2 was associated with inflammation and might be considered as a material which could delay the damage of kidney in IgAN. In the future, larger cohort and long-term follow-up studies are needed to demonstrate the role of 15d-PGJ2 as prognostic indicator or marker of kidney damage.

Keyword

Immunoglobulin A nephropathy; 15-deoxy-delta (12,14)-prostaglandin J2; Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

MeSH Terms

Cohort Studies
Corneal Dystrophies, Hereditary
Cytokines
Follow-Up Studies
Glomerulonephritis, IGA
Hematuria
Humans
Immunoglobulin A
Inflammation
Interleukin-23
Interleukin-6
Kidney
Prostaglandin D2
Proteinuria
Transforming Growth Factor beta1
Corneal Dystrophies, Hereditary
Cytokines
Immunoglobulin A
Interleukin-23
Interleukin-6
Prostaglandin D2
Transforming Growth Factor beta1