J Asthma Allergy Clin Immunol.  2000 Aug;20(4):601-608.

Inhibition of IgE-mediated anaphylactic reaction by Mentha arvensis in rats

Affiliations
  • 1College of Pharmacy, College of Science, Woosuk University, Chonju, Chonbuk, South Korea.
  • 2College of Pharmacy, College of Engineering, Woosuk University, Chonju, Chonbuk, South Korea.

Abstract

BACKGROUND
It has been reported that Mentha arvensis water extract (MAWE) inhibited systemic anaphylaxis and histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80.
OBJECTIVE
AND METHOD: This study was undertaken to determine the inhibitory effects of immunoglobulin E (IgE)-mediated anaphylactic reaction by MAWE. This paper deals with an evaluation of the effect of MAWE on the anti-dinitrophenyl (DNP) IgE antibody induced anaphylactic reaction in rats. We also investigated the influence of MAWE on anti-DNP IgE antibody-induced tumor necrosis factor-alpha (TNF-alpha) production.
RESULTS
MAWE inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intrap- eritoneally, and orally administered. MAWE dose-dependently inhibited histamine release from RPMC activated by anti-DNP IgE antibody. Moreover, MAWE had an inhibitory effect on anti-DNP IgE antibody induced TNF-alphaproduction from RPMC.
CONCLUSION
These results suggest that MAWE inhibits the IgE-mediated anaphylactic reaction in rats.

Keyword

Mentha arvensis; anaphylactic reaction; TNF-alpha; anti-dinitrophenyl IgE; mast cells

MeSH Terms

Anaphylaxis*
Animals
Histamine Release
Immunoglobulin E
Immunoglobulins
Mast Cells
Mentha*
Passive Cutaneous Anaphylaxis
Rats*
Tumor Necrosis Factor-alpha
Water
Immunoglobulin E
Immunoglobulins
Tumor Necrosis Factor-alpha
Water
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