J Asthma Allergy Clin Immunol.
2000 Aug;20(4):601-608.
Inhibition of IgE-mediated anaphylactic reaction by Mentha arvensis in rats
- Affiliations
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- 1College of Pharmacy, College of Science, Woosuk University, Chonju, Chonbuk, South Korea.
- 2College of Pharmacy, College of Engineering, Woosuk University, Chonju, Chonbuk, South Korea.
Abstract
- BACKGROUND
It has been reported that Mentha arvensis water extract (MAWE) inhibited systemic anaphylaxis and histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80.
OBJECTIVE
AND METHOD: This study was undertaken to determine the inhibitory effects of immunoglobulin E (IgE)-mediated anaphylactic reaction by MAWE. This paper deals with an evaluation of the effect of MAWE on the anti-dinitrophenyl (DNP) IgE antibody induced anaphylactic reaction in rats. We also investigated the influence of MAWE on anti-DNP IgE antibody-induced tumor necrosis factor-alpha (TNF-alpha) production.
RESULTS
MAWE inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intrap- eritoneally, and orally administered. MAWE dose-dependently inhibited histamine release from RPMC activated by anti-DNP IgE antibody. Moreover, MAWE had an inhibitory effect on anti-DNP IgE antibody induced TNF-alphaproduction from RPMC.
CONCLUSION
These results suggest that MAWE inhibits the IgE-mediated anaphylactic reaction in rats.
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