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Factors Predicting the Response to Cyclosporin Treatment in Patients With Chronic Spontaneous Urticaria: A Systematic Review

Kulthanan , Subchookul C, Hunnangkul S, Chularojanamontri L, Tuchinda P

PURPOSE: This study aimed to systemically review literature relating to factors that could potentially predict a favorable response to cyclosporine A (CsA) treatment for chronic spontaneous urticaria (CSU). METHODS: A systematic...
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Allergy to carminic acid: in vitro evidence of involvement of protein-binding hapten

Osumi M, Yamaguchi , Sugimoto N, Suzukawa M, Arai H, Akiyama H, Nagase H, Ohta K

We previously described a rare case of anaphylaxis presumably induced by carminic acid in cochineal dye used as a food additive. In this study, highly pure carminic acid was added...
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Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

Bui TT, Piao CH, Song CH, Lee CH, Shin HS, Chai OH

Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of...
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Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1

Moreno A, Pineda F, Alcover J, Rodríguez D, Palacios R, Martínez-Naves E

PURPOSE: Hypersensitivity to fungi is associated with rhinoconjunctivitis and asthma. For some fungi, such as Alternaria alternata (A. alternata), the symptoms of asthma are persistent, increasing disease severity and the...
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Gastrodia elata Blume Attenuates 2, 4-Dinitrochlorobenzene-induced Atopic Dermatitis-like Skin Lesions in Balb/c Mice and SD Rats

Kim NH, Lee MR, Lee YM

Gastrodia elata Blume is a well-known kind of natural products used as a folk medicine for thousands of years. However, anti-atopic dermatitis-like effects of G. elata Blume had not been...
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Role of mast cell in the late phase of contact hypersensitivity induced by trimellitic anhydride

Chai OH, Song CH

Mast cells are known as effector cells of IgE-mediated allergic responses, but role of mast cells in contact hypersensitivity (CHS) has been considered controversial. In this study, we investigated role...
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Blocking of Histamine Release and IgE Binding to FcepsilonRI on Human Basophils by Antibodies Produced in Camels

Khaled AQ, Sana Y, Abdulrahman R, Raida K, Sami AH

PURPOSE: The production of camel heavy-chain antihuman IgE (huIgE) that has the potential to block IgE-FcepsilonRI interaction and histamine release by basophils. METHODS: Camels were immunized with a synthetic loop peptide...
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Effects of C18 Fatty Acids on Intracellular Ca2+ Mobilization and Histamine Release in RBL-2H3 Cells

Kim MC, Kim MG, Jo YS, Song HS, Eom TI, Sim SS

To investigate the underlying mechanisms of C18 fatty acids (stearic acid, oleic acid, linoleic acid and alpha-linolenic acid) on mast cells, we measured the effect of C18 fatty acids on...
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Evaluation of the Stabilization of Human Umbilical Cord Blood-Derived Mast Cells in Accordance with Ketotifen and Olopatadine Concentration

Chun JW, Koh JW

PURPOSE: To evaluate the effect of olopatadine and ketotifen to stabilize mast cells using human umbilical cord blood-derived mast cells (hCBMCs). METHODS: Using cultured hCBMCs, we divided the cells into the...
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A Case of Codeine Induced Anaphylaxis via Oral Route

Yoo HS, Yang EM, Kim MA, Hwang SH, Shin YS, Ye YM, Nahm DH, Park HS

Codeine is widely prescribed in clinical settings for the relief of pain and non-productive coughs. Common adverse drug reactions to codeine include constipation, euphoria, nausea, and drowsiness. However, there have...
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Histamine-Releasing Factor and Immunoglobulins in Asthma and Allergy

Kawakami T, Kashiwakura JI, Kawakami Y

Factors that can induce the release of histamine from basophils have been studied for more than 30 years. A protein termed histamine-releasing factor (HRF) was purified and molecularly cloned in...
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The Influence of IgE on Cultured Human Mast Cells

Frandsen P, Krohn IJ, Hoffmann H, Schiotz PO

PURPOSE: The mast cell plays a pivotal role in the human immune response. Crosslinking of 2 IgE molecules bound to the high affinity IgE receptor (FcepsilonRI) on the surface of...
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Effect of Anti-Siglec-F Antibody and Reactive Oxygen Species Blocking on Histamine Release in Urinary Bladder of Ovalbumin-Treated Mice

Choi BH, Choo GY, Kang JH, Lee CY, Park CS

  • KMID: 2232963
  • Int Neurourol J.
  • 2012 Sep;16(3):122-125.
PURPOSE: Sialic acid-binding Ig-like lectin (Siglec) is an immune inhibitory receptor that plays a role in the negative regulation of the activation of immune cells. This study aimed to evaluate...
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Comparison of the Efficacy of Topical Antihistamine/Mast Cell Stabilizers in vitro

Kim SJ, Yoon TJ, Lee JE, Lee JS

  • KMID: 2337815
  • J Korean Ophthalmol Soc.
  • 2010 Mar;51(3):406-417.
PURPOSE: To investigate the biologic effects of topical anti-allergic agents with H1-receptor antagonism and inhibition of histamine release from mast cells in the cultured conjunctival cells of patients with vernal...
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Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation

Choi YH, Yan GH, Chai OH, Song CH

Mast cells participate in allergies and inflammation by secreting a variety of pro-inflammatory mediators. Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative, and anti-allergic...
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Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions

Choi YH, Han EH, Chai OH, Kim YK, Kim HT, Song CH

  • KMID: 1462534
  • Korean J Phys Anthropol.
  • 2010 Dec;23(4):217-227.
Mast cells play a critical role in the effector phase of immediate hypersensitivity and allergic diseases. Scutellaria baicalensis is a widely used herb in traditional oriental medicine with anticancer, antiviral,...
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Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction

Choi YH, Chai OH, Han EH, Choi SY, Kim HT, Song CH

Alpha-lipoic acid (LA), a naturally occurring dithiol compound, is an essential cofactor in metabolic reactions involved in energy utilization. LA improves glycemic control, reduces diabetic polyneuropathies, atherosclerosis, and allergic inflammation....
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Study of Cutaneous Neuropeptides-induced Mast Cell Activation

Na YC, Chai OH, Song CH

  • KMID: 1472492
  • Korean J Anat.
  • 2009 Sep;42(3):197-207.
Neuropeptides are widely distributed throughout skin, gastrointestinal tracts, and nervous and immune systems. Neuropeptides act to mediate the vasodilation and induce mast cell activation in humans and rats in vitro....
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Inhibitory Effect of Bear Bile on Compound 48/80-induced Mast Cell Activation and IgE-mediated Vascular Permeability

Yan GH, Choi YH, Chai OH, Song CH

  • KMID: 2283673
  • Korean J Phys Anthropol.
  • 2009 Mar;22(1):71-83.
The bear bile has been used as a traditional drug medicine and has been known to have anti-tumor, anti-inflammatory and anti-oxidant effects. The purpose of this study is to investigate...
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A Case of Codeine Induced Urticaria/Angioedema

  • KMID: 2234536
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Sep;28(3):234-237.
A 26-year-old female patient had complained of generalized urticaria with perioral and periorbital angioedema within 30 minutes after taking 20 mg of codeine phosphate. She had suffered from allergic rhinitis...
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