Allergy.
1995 Jun;15(2):239-249.
Mugwort pollen- induced bnsophil histamine releasability in seasonal allergic rhinitis and asthma
Abstract
- Mediator release from mast cells and conceivably circulating basophil leukocytes is intimately involved in the pathogenesis of immediate hypersensitivity. The study of the basophil histamine releasability may be very helpful to under stand the pathogenesis of allergic disease. 'Some studies have been performed in rag weed pollen sensitive allergic rhinitis and asthma using human basophils, but controversy still remains about the difference in releasability between the disease entity and relation with other immunologic parameters. The mugwort pollen induced peripheral histamine releasability in nine rhinitis patients and thirteen asthma patients was studied to evaluate the difference between the disease entities and to compare with other parameters, such as skin reactivity, RAST, and allergen induced bronchial hyperreactivity. Mugwort pollen induced peripheral basophil histamine release was obeserved at the concentration of 1 x 10-5 to 1 x 10-3w/v and it showea dose dependent fashion. But histamine release was not observed in normal control. Maximal net histamine releasability of asthma group was 73+/--5.9% which was significantly greater than that of rhinitis group 39.1+/-7.2% (p<0.05). But there was no significant correlation between the degree of allergen induced bronchial hyperreactivity and histamine releasability. We concluded that pollen induced basophil releasability is allergen specific and it is useful for confirming the offending allergen and for differential diagnosis of rhinitis and asthma. But basophil histamine releasability can not reflect the severity of asthma. Further study for the difference between intrinsic basophil releasbility and effect of several cytokines on basophil releasability should be inveatigated.
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