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Prevalence and Clinical Characteristics of Asymptomatic Pyuria in Chronic Kidney Disease

Kwon YE, Oh DJ, Kim MJ, Choi HM

BACKGROUND: Pyuria seems to be common in chronic kidney disease (CKD), irrespective of urinary tract infection (UTI). It has been hypothesized that sterile pyuria occurs in CKD because of chronic...
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Extracting Structured Genotype Information from Free-Text HLA Reports Using a Rule-Based Approach

Lee KH, Kim HJ, Kim YJ, Kim JH, Song EY

BACKGROUND: Human leukocyte antigen (HLA) typing is important for transplant patients to prevent a severe mismatch reaction, and the result can also support the diagnosis of various disease or prediction...
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Is there an association between platelet and blood inflammatory indices and the risk of gestational diabetes mellitus?

Fashami MA, Hajian S, Afrakhteh , Khoob MK

OBJECTIVE: Gestational diabetes mellitus (GDM) is the most prevalent medical complication in pregnancy. Early diagnosis of GDM can influence maternal/neonatal outcomes. To assess the association between platelet and blood inflammatory...
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Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC

PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to...
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Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases: A Single Center Experience

Kwon WK, Choi S, Kim HJ, Huh HJ, Kang JM, Kim YJ, Yoo KH, Ahn K, Cho HK, Peck KR, Jang JH, Ki CS, Kang ES

PURPOSE: While there is an urgent need for diagnosis and therapeutic intervention in patients with primary immunodeficiency diseases (PIDs), current genetic tests have drawbacks. We retrospectively reviewed the usefulness of...
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Performance Evaluation of Body Fluid Cellular Analysis Using the Beckman Coulter UniCel DxH 800, Sysmex XN-350, and UF-5000 Automated Cellular Analyzers

Cho J, Oh J, Lee SG, Lee YH, Song J, Kim JH

BACKGROUND: Automated cellular analyzers are expected to improve the analytical performance in body fluid (BF) analysis. We evaluated the analytical performance of three automated cellular analyzers and established optimum reflex...
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The effects of pentoxifylline and tocopherol in jaw osteomyelitis

Seo MH, Eo MY, Myoung H, Kim SM, Lee JH

OBJECTIVES: Pentoxifylline (PTX) is a methylxanthine derivative that has been implicated in the pathogenesis of peripheral vessel disease and intermittent lameness. The purpose of this study was to investigate the...
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Echocardiographic Evaluation of Axial Spondyloarthritis in Korea: Data From the Catholic Axial Spondyloarthritis Cohort

Min HK, Lee J, Ju JH, Kwok SK, Youn HJ, Park SH

OBJECTIVE: Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA...
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Preoperative sterile pyuria as a prognostic biomarker for intravesical recurrence in upper urinary tract urothelial carcinoma

Jeon BJ, Tae BS, Choi H, Bae JH, Kim JW, Park HS, Park JY

PURPOSE: To evaluate if preoperative sterile pyuria can be a prognostic factor for intravesical recurrence (IVR) and overall survival (OS)in patients with upper tract urothelial carcinoma (UTUC) undergoing surgery. MATERIALS AND...
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Clinical significance of donor-specific anti-HLA-DR51/52/53 antibodies for antibody-mediated rejection in kidney transplant recipients

Park BG, Park Y, Joo DJ, Huh KH, Kim MS, Kim SI, Kim YS, Kim HS

BACKGROUND: The presence of donor-specific antibodies (DSAs) to human leukocyte antigen (HLA) increases the risk of antibody-mediated rejection (ABMR) after kidney transplantation (KT). However, the clinical relevance of anti-HLA-DR51/52/53 antibodies...
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Factors Affecting Vascular Clogging, Wound Status and Bacterial Culture in Diabetic Foot Ulcers

Kim JL, Shin JY, Roh SG, Chang SC, Lee NH

BACKGROUND: We assumed that vascular clogging, wound status, and bacterial culture tests are significant characteristics in developing a treatment plan for diabetic patients with foot ulcers. The goal of our...
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Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review

Torres-Aguila NP, Carrera C, Muiño E, Cullell N, Cárcel-Márquez J, Gallego-Fabrega C, González-Sánchez J, Bustamante A, Delgado P, Ibañez L, Heitsch L, Krupinski , Montaner J, Martí-Fàbregas J, Cruchaga C, Lee JM, Fernandez-Cadenas I, Acute Endophenotypes Group of the International Stroke Genetics Consortium (ISGC)

Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome,...
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Analysis of differences in human leukocyte antigen between the two Wellcome Trust Case Control Consortium control datasets

Jang CS, Choi W, Cook S, Han B

The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide association study that aimed to identify common variants associated with seven diseases. That study combined two control datasets...
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Comparison of Red Blood Cell, White Blood Cell and Differential Counts between UF-5000 System and Manual Method

Koo MS, Lim J, Kim SY, Koo SH, Kwon GC

BACKGROUND: Analysis of body fluids provides important information for assessing various medical conditions. We aimed to validate the analytical and diagnostic performance of the Sysmex UF-5000 (Sysmex, Japan) system for...
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Annual Report of Korean Association of External Quality Assessment Service on Histocompatibility Testing (2018)

Kang ES

Here, we report the results of the first histocompatibility proficiency testing (PT) performed by the Korean Association of External Quality Assessment Service in 2018. The directly prepared PT specimens of...
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Genetic aspects of type 1 diabetes

Lee HS, Hwang JS

Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of...
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Eosinophilic Enteritis Presenting as Massive Ascites after Influenza A Virus Infection in a Young Female

Kim MJ, Oh MJ

Eosinophilic gastrointestinal disorder (EGID) is an uncommon disease that is accompanied by intestinal eosinophil infiltration without a secondary cause of eosinophilia. Eosinophilic enteritis is a secondary portion of EGID that...
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Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment

Kim TO, Shin HJ, Kim YI, Lim SC, Koh YI, Kwon YS

BACKGROUND/AIMS: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral...
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Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells

Roolf C, Saleweski , Stein A, Richter A, Maletzki C, Sekora A, Escobar HM, Wu XF, Beller M, Junghanss

Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified...
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Roles of Ureaplasma Species in Idiopathic Chronic Prostatitis: A Case-Control Study

Park H, Lee G

PURPOSE: Because of the inconsistent symptoms associated with Ureaplasma infections, their clinical significances in genitourinary tracts are under debate. Therefore, we evaluated the presence of Ureaplasma urealyticum (UU) and Ureaplasma...
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