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Acute toxicity of benzalkonium chloride in Balb/c mice following intratracheal instillation and oral administration

Lee H, Park K

Benzalkonium chloride is a cationic surfactant widely used as a disinfectant, preservative, and sanitizer in many public places as well as domestically. The purpose of this study is to compare...
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Antibiotic Treatment of Vertebral Osteomyelitis caused by Methicillin-Susceptible Staphylococcus aureus: A Focus on the Use of Oral β-lactams

Oh WS, Moon C, Chung JW, Choo EJ, Kwak YG, Kim SH, Ryu SY, Park SY, Kim BN

BACKGROUND: Vertebral osteomyelitis (VO) is a rare but serious condition, and a potentially significant cause of morbidity. Methicillin-susceptible Staphylococcus aureus (MSSA) is the most common microorganism in native VO. Long-term...
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Effects of Fimasartan/Amlodipine Fixed-Dose Combination on Left Ventricular Systolic Function and Infarct Size in Rat Myocardial Infarction Model

Kim HB, Hong YJ, Park HJ, Ahn Y, Jeong MH

The aim of this study was to evaluate the effects of fimasartan/amlodipine fixed-dosed combination (F/A) on left ventricle (LV) systolic function and infarct size in the rat myocardial infarction (MI)...
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The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations

Jung WY, Kim SG, Kim HK, Huh SY, Kim DW, Yoon DU, Yang CH, Kim HY, Jang EY

OBJECTIVE: Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is...
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Anti-atopic dermatitis effect of the soybean fermented by B. amyloliquefaciens via inhibiting IL-31

Hong S, Hwang SW, Yang HJ, Jeong DY, Kim O

The occurrence of allergic disease has increased harmfully in the last few decades. Atopic dermatitis (AD) is an allergic inflammation disorder characterized by itchy, red, swollen, cracked skin. Although the...
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Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

Sung HH, Yu J, Kang SJ, Chae MR, So I, Park JK, Lee SW

PURPOSE: The current study is aimed to assess whether a longer duration of 5α-reductase inhibitor (5α-RI) exposure was associated with higher rate of permanent erectile dysfunction (ED) in a rat...
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Preparation, characterization, and in vivo evaluation of a polymorphic form of valnemulin hydrogen tartrate

Zhu X, Xu S, Lu L, Wang S, Zhao Q, Li D, Li J, Zhao H, Xu B

We prepared a polymorphic form of valnemulin hydrogen tartrate (Form I) to overcome the instability and irritating odor of valnemulin hydrochloride that affect its use in the production and application...
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Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway

Zhang Q, Hu LQ, Li HQ, Wu J, Bian NN, Yan G

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats...
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Long term effects after telmisartan administration for cardiovascular-renal axis disorder in cats

Han D, Jung DI

The interaction between the cardiac and renal systems is important in determining blood pressure and blood volume, both of which play a role in the vasomotor system and fluid balance....
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Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

Kim GH, Yi SS

Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not...
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Protective effect of glucosamine and risedronate (alone or in combination) against osteoarthritic changes in rat experimental model of immobilized knee

Salman A, Shabana AI, El-ghazouly DEs, Maha E

This study is aiming to investigate the protective effect of glucosamine, risedronate (alone or in combination) on articular cartilage in experimental model of immobilized rat knee. Twenty-five adult male albino...
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Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Kim JE, Sharma A, Sharma G, Lee SY, Shin HS, Rudra D, Im SH

Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify...
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Anti-diabetic effects of blue honeyberry on high-fed-diet-induced type II diabetic mouse

Sharma A, Kim JW, Ku SK, Choi JS, Lee HJ

BACKGROUND/OBJECTIVE: The blue honeysuckle berry (Lonicera caerulea var. edulis L.) is a small deciduous shrub belonging to the Caprifoliaceae family that is native to Russia, China, Japan, and Korea. The...
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3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABA(A)-benzodiazepine Receptors

Woo J, Yang H, Yoon M, Gadhe CG, Pae AN, Cho S, Lee CJ

3-Carene, a bicyclic monoterpene, is one of the major components of the pine tree essential oils. It has been reported that, in addition to its known properties as a phytoncide,...
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Anti-influenza properties of herbal extract of Althaea rosea in mice

Kim MS, Chathuranga K, Kim H, Lee JS, Kim CJ

Althaea rosea has been used in traditional Chinese medicine to treat numerous diseases, but no studies have investigated its anti-influenza properties to date. In this study, we investigated the anti-influenza...
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Pharmacokinetics of enrofloxacin HCl-2Hâ‚‚O (Enro-C) in dogs and pharmacokinetic/pharmacodynamic Monte Carlo simulations against Leptospira spp.

Sumano H, Ocampo L, Tapia G, Mendoza CD, Gutierrez

Pharmacokinetic/pharmacodynamic (PK/PD) ratios of reference enrofloxacin (Enro-R) and enrofloxacin as HCl-2H₂O (Enro-C), as well as Monte Carlo simulations based on composite MIC₅₀ and MIC₉₀ (MIC, minimum inhibitory concentration) vs. Leptospira...
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Effects of Ivabradine on Left Ventricular Systolic Function and Cardiac Fibrosis in Rat Myocardial Ischemia-Reperfusion Model

Kim HB, Hong YJ, Park HJ, Ahn Y, Jeong MH

We evaluated the effects of Ivabradine on left ventricle (LV) ejection fraction (EF) and LV infarcted tissue in the rat myocardial ischemia-reperfusion model. Twenty rats were randomly assigned to group...
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Rivaroxaban and Acetylsalicylic Acid for Prevention of Venous Thromboembolism Following Total Knee Arthroplasty in Korean Patients

Chung KS, Shin TY, Park SH, Kim H, Choi CH

PURPOSE: To investigate the incidence of venous thromboembolism (VTE) after total knee arthroplasty (TKA) with chemoprophylaxis using acetylsalicylic acid (AA) or rivaroxaban in Korean patients. MATERIALS AND METHODS: Between May 2011...
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The Effect of Postoperative Use of Teriparatide Reducing Screw Loosening in Osteoporotic Patients

Kim JW, Park SW, Kim YB, Ko MJ

OBJECTIVE: The loosening of pedicle screws (PS) is one of the frequent problems of spinal surgery in the patients with osteoporosis. Previous studies had revealed that intermittent injection of teriparatide...
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Salivary Cortisol and Pain Scoring to Compare the Efficacy of Oral Dextrose and Pacifier for Neonatal Pain Control

Jin H, Kim IA, Jeong MH, Park KY, Kim BS

OBJECTIVE: Pain assessment usually involves the use of subjective pain scales; as their use may be associated with inter-/intra-observer bias, objective pain measurements, such as assessment of cortisol response to...
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