J Korean Assoc Oral Maxillofac Surg.  2010 Dec;36(6):508-514.

Clinical feature and treatment of bisphosphonate-related osteonecrosis of jaw about oral bisphosphonate administrated patients: case reports

• Choi WS
• Yoon HJ
• Lee SH

Abstract

Bisphosphonates are used effectively for many medical conditions, such as multiple myeloma, Paget's disease, osteoporosis, etc. However, recently, osteonecrosis of the jaw was observed in patients receiving long-term bisphosphonate therapy, including oral administration. This osteonecrosis is refractory, and complete recovery is not guaranteed despite a standard treatment protocol being established by many associations related to oral and maxillofacial surgery. The treatment outcome of oral bisphosphonate-related osteonecrosis of jaw (BRONJ) is reported with a review of the relevant literature.

Keyword

Bisphosphonate; Osteonecrosis; Osteoporosis

MeSH Terms

Administration, Oral
Clinical Protocols
Diphosphonates
Humans
Jaw
Multiple Myeloma
Osteonecrosis
Osteoporosis
Surgery, Oral
Treatment Outcome
Diphosphonates