J Korean Acad Rehabil Med.  2010 Oct;34(5):599-602.

Oral Bisphosphonate Related Osteonecrosis of the Jaws: A case report

• Jeong JS
• Lee JK

Abstract

Bisphosphonates are the most widely prescribed medications for the treatment of osteoporosis. However, bisphosphonate-related osteonecrosis of the jaw (BRONJ) is recently recognized as a serious complication among patients receiving bisphosphonate therapy. Most reports relate to BRONJ result from intravenous bisphosphonate or dental procedure. We report a case of mandible osteonecrosis related with oral bisphosphonate medication. A-63-year old woman suffered from toothache, cheek swelling and heating sense visited our dental clinic. She had taken oral alendronate and antihypertensive agents for 4 years because of osteoporosis and hypertension. Dental physical examination, radiologic study and pathologic study showed the severe inflammation and osteonecrosis of the mandible. Therefore we diagnosed the patient as having BRONJ and she stopped to take bisphosphonate and received surgical treatment with bone curettage. After surgical treatment and stopping bisphosphonate, her symptoms were improved.

Keyword

Osteoporosis; Bisphosphonate; Osteonecrosis

MeSH Terms

Alendronate
Antihypertensive Agents
Bisphosphonate-Associated Osteonecrosis of the Jaw
Cheek
Curettage
Dental Clinics
Diphosphonates
Female
Heating
Hot Temperature
Humans
Hypertension
Inflammation
Mandible
Osteonecrosis
Osteoporosis
Physical Examination
Polymethacrylic Acids
Toothache
Alendronate
Antihypertensive Agents
Diphosphonates
Polymethacrylic Acids