Yonsei Med J.  1991 Sep;32(3):231-236. 10.3349/ymj.1991.32.3.231.

Study of the skin concentrations after administration of the various phototoxic drugs

• Park YK
• Hann SK
• Cho MY
• Kim HJ
• Shim SC
• Choi SJ
• Yun MH

• KMID: 1729590
• DOI: http://doi.org/10.3349/ymj.1991.32.3.231

Abstract

The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP

Keyword

Skin concentration; 8-MOP; 5-MOP; TMP

MeSH Terms

Administration, Cutaneous
Administration, Oral
Animal
Guinea Pigs
Methoxsalen/administration & dosage/*analysis
PUVA Therapy
Skin/*chemistry
Support, Non-U.S. Gov't
Trioxsalen/administration & dosage/*analysis