Continuous Bladder Irrigation with Amphotericin B versus Oral Administration of Fluconazole in Patients with Candiduria

Kim, Hyeung Nam; Oh, Bong Ryoul; Park, Yang Il

Abstract

PURPOSE: The efficacy of continuous bladder irrigation with amphotericin B versus oral administration of fluconazole(Diflucan ) was compared in the treatment of patients with candiduria. .
MATERIALS AND METHODS
A prospective and comparative study of candiduriawas done on 28 patients(Amphotericin B: 13, Fluconazole: 15). Continuous bladder irrigation with 50mg amphotericin B/iota sterile water infused during 24 hours for 2 days was compared to oral administration of 50-100mg/day fluconazole for a range of 7-14 days. Urine culture were obtained 3days, 7 days after continuous bladder irrigation with amphotericin B and 7 days, 14 days after oral administration of fluconazole.
RESULTS
The organism was eradicated in 10 patients(76.9%) who received continuous irrigation of amphotericin B and 11 patients(73.3%) who received oral fluconazole therapy. So, There was no statistically significant difference between continuous bladder irrigation with Amphotericin B group and oral medication of fluconazole group(p>0.05).
CONCLUSIONS
There was no difference in the cure rate of candiduria between continuous bladder irrigation with Amphotericin B group and oral medication of fluconazole group. So, patient's condition(Foley catheterization, possibility of ambulation and oral feeding) and convinience will be the important deciding factors to select adequate treatment method of candiduria.