Korean J Med Mycol.  2009 Sep;14(3):145-149.

Candida Spondylodiscitis with Epidural Abscess Treated with Voriconazole

• Noh JY
• Heo JY
• Choi WS
• Jo YM
• Song JY
• Cheong HJ
• Kim WJ

Abstract

Candida spondylodiscitis with epidural abscess is rarely reported and known to be the late complication of candidemia. A 48-years-old man presented with 4 weeks of progressively aggravating low back pain. He had a history of fungemia caused by Candida albicans 4 months earlier, for which he had been treated successfully with systemic fluconazole. The MRI of lumbar spine demonstrated the spondylodiscitis with multiple epidural abscesses at the L2/3 level. Along with the surgical interventions including abscess drainage, the intravenous amphotericin B administration was begun. Culture of drained pus yielded the growth of Candida albicans. After therapy with parenteral amphotericin B for 2 weeks followed by oral fluconazole for 8 weeks, the back pain resolved. However the low back pain and inflammation relapsed during oral fluconazole therapy. Thereafter oral voriconazole had been administered for 24 weeks and the patient showed complete recovery and no recurrence.

Keyword

Candida; Spondylodiscitis; Voriconazole

MeSH Terms

Abscess
Amphotericin B
Back Pain
Candida
Candida albicans
Candidemia
Discitis
Drainage
Epidural Abscess
Fluconazole
Fungemia
Humans
Inflammation
Low Back Pain
Pyrimidines
Recurrence
Spine
Suppuration
Triazoles
Amphotericin B
Fluconazole
Pyrimidines
Triazoles