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Update on Gastrointestinal Stromal Tumors for Radiologists

Tirumani S, Baheti AD, Tirumani H, O'Neill A, Jagannathan JP

The management of gastrointestinal stromal tumors (GISTs) has evolved significantly in the last two decades due to better understanding of their biologic behavior as well as development of molecular targeted...
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Pazopanib as a second line treatment for uterine and ovarian carcinosarcoma: a single institutional study

Nishikawa , Hasegawa K, Yabuno A, Yoshida H, Yasuda M, Kozawa E, Fujiwara K

No abstract available.
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Oral udenafil and aceclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: a randomized multicenter study

Lee TY, Choi JS, Oh HC, Song TJ, Do JH, Cheon YK

BACKGROUND/AIMS: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Combination therapy w ith ora l udenafil and aceclofenac may reduce the occurrence of post-ERCP pancreatitis by targeting...
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A Novel Angiotensin Type I Receptor Antagonist, Fimasartan, Prevents Doxorubicin-induced Cardiotoxicity in Rats

Chang SA, Lim BK, Lee YJ, Hong MK, Choi JO, Jeon ES

Angiotensin receptor blockers (ARBs) have organ-protective effects in heart failure and may be also effective in doxorubicin-induced cardiomyopathy (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have...
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Fluid Retention Associated with Imatinib Treatment in Patients with Gastrointestinal Stromal Tumor: Quantitative Radiologic Assessment and Implications for Management

Kim KW, Shinagare , Krajewski , Pyo J, Tirumani S, Jagannathan JP, Ramaiya NH

OBJECTIVE: We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. MATERIALS AND METHODS: In this...
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beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells

Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I

An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene....
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Current and Emerging Biologics for Ulcerative Colitis

Park SC, Jeen YT

Conventional medical treatment for ulcerative colitis can have limited efficacy or severe adverse reactions requiring additional treatment or colectomy. Hence, different biological agents that target specific immunological pathways are being...
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Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction

Sim DS, Jeong MH, Song HC, Kim J, Chong A, Bom HS, Jeong IS, Oh SG, Kim JM, Park DS, Kim JH, Lim KS, Kim MS, Ryu SH, Kim HK, Kim SS, Jang SY, Cho JY, Jeong HC, Lee KH, Park KH, Yoon NS, Yoon HJ, Kim KH, Hong YJ, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC

Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10),...
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Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials

Song GG, Bae SC, Lee YH

BACKGROUND/AIMS: The aim of this study was to assess the efficacy and safety of tofacitinib (5 and 10 mg twice daily) in patients with active rheumatoid arthritis (RA). METHODS: A systematic...
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Could tofacitinib, the first oral small-molecule inhibitor proven for use in active rheumatoid arthritis (RA) patients with insufficient response to methotrexate, be the breakthrough drug for RA?

Kwok SK

No abstract available.
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Rapid Sequential Gain of ABL1 Kinase Domain Mutations with a Complex Karyotype in the Progression of Chronic Myelogenous Leukemia

Chung Y, Eom HS, Lee H, Park S, Shim H, Cho EH, Kong SY

No abstract available.
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A Case of Isolated Lymphoblastic Relapse of the Central Nervous System in a Patient with Chronic Myelogenous Leukemia Treated with Imatinib

Park MJ, Park PW, Seo YH, Kim KH, Seo JY, Jeong JH, Kim MJ, Jeong JW, Ahn JY, Park J

No abstract available.
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Chronic myeloid leukemia as a secondary malignancy after diffuse large B-cell lymphoma

Lee HY, Lee KH, Hyun MS, Kim MK, Koh SA, Cho HS

No abstract available.
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Inhibition of intimal hyperplasia by local perivascular application of rapamycin and imatinib mesilate after carotid balloon injury

Park D, Kim SM, Min SI, Ha J, Kim IG, Min SK

PURPOSE: Inhibition of the intimal hyperplasia after vascular surgery is an important issue. The purpose of this study is to define whether perivascular application of rapamycin, imatinib mesylate or cysteamine...
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Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1

Lee KK, Kim HB, Heo MH, Kim JY, Do YR, Park KU, Song HS

  • KMID: 2267780
  • Korean J Med.
  • 2013 Nov;85(5):535-539.
Neurofibromatosis type 1 (NF1) is a genetic disease characterized by neoplastic and non-neoplastic disorders involving tissues of neuroectodermal and mesenchymal origin. NF1 is caused by mutations in the NF1 gene,...
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Plantar Keratoderma with Pachyonychia Likely Induced by Imatinib Mesylate

Kim HO, Lee BI, Lee JY, Park YM

No abstract available.
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Lichenoid Drug Eruption after Low-Dose Imatinib Mesylate Treatment

Lee JH, Chung JY, Jung MY, Kim CR, Park JH, Park JH, Lee JH, Lee JH, Yang JM, Lee DY

No abstract available.
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Data Analysis for Anti-Neoplastic Chemotherapy-Related Adverse Events Reported to the Korean Pharmacovigilance Regional Network

Lee JY, Jung JW, Kang HR, Lee SH, Kim HS, Cho SH

  • KMID: 2267789
  • Korean J Med.
  • 2013 Oct;85(4):385-395.
BACKGROUND/AIMS: To describe the toxicity profile of anti-neoplastic agents from real clinical settings, we analyzed spontaneously reported adverse events (AEs) using data from the adverse drug reaction (ADR) reporting system...
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Diagnosis and Treatment of Gastrointestinal Stromal Tumor

Kang YK, Koo DH

  • KMID: 2267783
  • Korean J Med.
  • 2013 Oct;85(4):341-353.
Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the gastrointestinal tract, have represented an important advance in oncology field with the success of molecular targeted therapy....
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A Localized Cutaneous Paecilomyces lilacinus Infection Treated with Voriconazole

Jung MY, Park JH, Lee JH, Lee JH, Yang JM, Lee DY

  • KMID: 1864414
  • Korean J Dermatol.
  • 2013 Oct;51(10):833-836.
Paecilomyces is a hyaline hyphomycete that exists worldwide. Paecilomyces lilacinus is associated most frequently with human infection. A 72-year-old male presented with a 1-month history of pruritic erythematous scaly plaque...
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