Ann Dermatol.  2013 Nov;25(4):526-528. 10.5021/ad.2013.25.4.526.

Plantar Keratoderma with Pachyonychia Likely Induced by Imatinib Mesylate

• Kim HO
• Lee BI
• Lee JY
• Park YM

• KMID: 2265085
• DOI: http://doi.org/10.5021/ad.2013.25.4.526

Abstract

No abstract available.

MeSH Terms

Benzamides
Mesylates*
Nails, Malformed*
Piperazines
Pyrimidines
Imatinib Mesylate
Benzamides
Mesylates
Piperazines
Pyrimidines

Figure

• 

  Fig. 1 (A) Symmetrically distributed, diffuse, hyperkeratotic, yellow-brownish plaques with fissures on the soles, and (B) hyperkeratosis of the finger nails and toe nails.

• 

  Fig. 2 Follow-up 17 months later. (A) Improvement of pachyonychia of thumb nails. (B, C) Improvement of hyperkeratosis of toenails.

Reference

1. Dalmau J, Peramiquel L, Puig L, Fernández-Figueras MT, Roé E, Alomar A. Imatinib-associated lichenoid eruption: acitretin treatment allows maintained antineoplastic effect. Br J Dermatol. 2006; 154:1213–1216.

2. Kuraishi N, Nagai Y, Hasegawa M, Ishikawa O. Lichenoid drug eruption with palmoplantar hyperkeratosis due to imatinib mesylate: a case report and a review of the literature. Acta Derm Venereol. 2010; 90:73–76.

3. Kwon EJ, Kish LS, Jaworsky C. The histologic spectrum of epithelial neoplasms induced by sorafenib. J Am Acad Dermatol. 2009; 61:522–527.