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Update on Gastrointestinal Stromal Tumors for Radiologists

Tirumani S, Baheti AD, Tirumani H, O'Neill A, Jagannathan JP

The management of gastrointestinal stromal tumors (GISTs) has evolved significantly in the last two decades due to better understanding of their biologic behavior as well as development of molecular targeted...
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Efficacy and Safety of Roflumilast in Korean Patients with COPD

Lee JS, Hong YK, Park TS, Lee SW, Oh YM, Lee SD

PURPOSE: Roflumilast is the only oral phosphodiesterase 4 inhibitor approved to treat chronic obstructive pulmonary disease (COPD) patients [post-bronchodilator forced expiratory volume in 1 second (FEV1)
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Fluid Retention Associated with Imatinib Treatment in Patients with Gastrointestinal Stromal Tumor: Quantitative Radiologic Assessment and Implications for Management

Kim KW, Shinagare , Krajewski , Pyo J, Tirumani S, Jagannathan JP, Ramaiya NH

OBJECTIVE: We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. MATERIALS AND METHODS: In this...
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Rapid Sequential Gain of ABL1 Kinase Domain Mutations with a Complex Karyotype in the Progression of Chronic Myelogenous Leukemia

Chung Y, Eom HS, Lee H, Park S, Shim H, Cho EH, Kong SY

No abstract available.
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A Case of Isolated Lymphoblastic Relapse of the Central Nervous System in a Patient with Chronic Myelogenous Leukemia Treated with Imatinib

Park MJ, Park PW, Seo YH, Kim KH, Seo JY, Jeong JH, Kim MJ, Jeong JW, Ahn JY, Park J

No abstract available.
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Chronic myeloid leukemia as a secondary malignancy after diffuse large B-cell lymphoma

Lee HY, Lee KH, Hyun MS, Kim MK, Koh SA, Cho HS

No abstract available.
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Inhibition of intimal hyperplasia by local perivascular application of rapamycin and imatinib mesilate after carotid balloon injury

Park D, Kim SM, Min SI, Ha J, Kim IG, Min SK

PURPOSE: Inhibition of the intimal hyperplasia after vascular surgery is an important issue. The purpose of this study is to define whether perivascular application of rapamycin, imatinib mesylate or cysteamine...
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Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1

Lee KK, Kim HB, Heo MH, Kim JY, Do YR, Park KU, Song HS

  • KMID: 2267780
  • Korean J Med.
  • 2013 Nov;85(5):535-539.
Neurofibromatosis type 1 (NF1) is a genetic disease characterized by neoplastic and non-neoplastic disorders involving tissues of neuroectodermal and mesenchymal origin. NF1 is caused by mutations in the NF1 gene,...
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Plantar Keratoderma with Pachyonychia Likely Induced by Imatinib Mesylate

Kim HO, Lee BI, Lee JY, Park YM

No abstract available.
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Lichenoid Drug Eruption after Low-Dose Imatinib Mesylate Treatment

Lee JH, Chung JY, Jung MY, Kim CR, Park JH, Park JH, Lee JH, Lee JH, Yang JM, Lee DY

No abstract available.
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Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

Lim HC, Kim JH, Youn YH, Lee EH, Lee BK, Park H

  • KMID: 2325770
  • J Neurogastroenterol Motil.
  • 2013 Oct;19(4):495-502.
BACKGROUND/AIMS: Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used...
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Diagnosis and Treatment of Gastrointestinal Stromal Tumor

Kang YK, Koo DH

  • KMID: 2267783
  • Korean J Med.
  • 2013 Oct;85(4):341-353.
Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the gastrointestinal tract, have represented an important advance in oncology field with the success of molecular targeted therapy....
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Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia

Oh HJ, Cho MS, Lee JW, Jang PS, Chung NG, Cho B, Kim HK

PURPOSE: Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the...
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Imatinib Plasma Monitoring-Guided Dose Modification for Managing Imatinib-Related Toxicities in Gastrointestinal Stromal Tumor Patients

Yoon S, Ryu MH, Yoo C, Beck MY, Ryoo BY, Kang YK

Imatinib, the first-line treatment in patients with advanced gastrointestinal stromal tumors (GIST), is generally well tolerated, although some patients have difficulty tolerating the standard dose of 400 mg/day. Adjusting imatinib...
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The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs

Park SJ, Choi EJ, Yoon YH, Park H

PURPOSE: Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and...
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A Case of Perforated Gastrointestinal Stromal Tumor in the Jejunum as a Rare Cause of Acute Abdomen

Kim SY, Kim JH, Park DS, Jang GS, Hong EY, An JS, Kim SY, Kim HY, Kim DH, Park JW, Baek IH, Park CK

Preoperative diagnosis of Gastrointestinal Stromal Tumors (GISTs) in the small intestine is often delayed until complications such as hemorrhage, bowel obstruction or perforation develop. Such GISTs are usually asymptomatic and...
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Surgical Treatment of Gastric Gastrointestinal Stromal Tumor

Kong SH, Yang HK

  • KMID: 2372222
  • J Gastric Cancer.
  • 2013 Mar;13(1):3-18.
Gastrointestinal stromal tumor is the most common mesenchymal tumor in the gastrointestinal tract and is most frequently developed in the stomach in the form of submucosal tumor. The incidence of...
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The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?

Michelucci A, Chiappetta C, Cacciotti , Veccia N, Astri E, Leopizzi M, Prosperi Porta R, Petrozza V, Della Rocca C, Bevilacqua G, Cavazzana , Di Cristofano C

  • KMID: 2053513
  • Gut Liver.
  • 2013 Jan;7(1):35-40.
BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes constitutive receptor activation leading to the development and growth of tumors;...
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A Case with Coexistence of Major and Minor BCR/ABL Fusion Transcript at Lymphoblastic Crisis of Chronic Myelogenous Leukemia in Patients with Major BCR/ABL Positivity during Chronic Phase

Park SH, Chi HS, Cho YU, Jang S, Park CJ, Im HJ

No abstract available.
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Recent Advances of Management for Chronic Myeloid Leukemia

Kim DW

  • KMID: 2264772
  • Korean J Med.
  • 2012 Dec;83(6):718-723.
The clinical outcome for patients with chronic myeloid leukemia (CML) has improved radically in the past 15 years. Imatinib led to high rates of complete cytogenetic responses and improved survival...
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