J Korean Diabetes.  2012 Mar;13(1):39-43. 10.4093/jkd.2012.13.1.39.

Pharmacotherapy for Postprandial Hyperglycemia in Type 2 Diabetes

• Yoo HJ

• KMID: 1436186
• DOI: http://doi.org/10.4093/jkd.2012.13.1.39

Abstract

A growing body of evidence shows that effective postprandial hyperglycemia management in individuals with type 2 diabetes can reduce the risk of diabetic complications and cardiovascular diseases. Therefore, accurate monitoring and effective intervention for postprandial hyperglycemia is very important in routine clinical practice for type 2 diabetes. Therapeutic modalities for the management of postprandial hyperglycemia include oral antidiabetic drugs (alpha glucosidase inhibitor, meglitinide, dipeptidyl peptidase-IV inhibitor), ultra-short-acting insulin analogues, and incretin mimetics. A detailed understanding of the advantages and disadvantages of various pharmacotherapies and a careful understanding of the underlying physical and social situations of each patient will be of great help to determine the appropriate prescription for postprandial hyperglycemia management.

Keyword

Hyperglycemia; Type 2 diabetes mellitus; Drug therapy

MeSH Terms

Benzamides
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus, Type 2
Glucosidases
Humans
Hyperglycemia
Hypoglycemic Agents
Incretins
Insulin
Prescriptions
Benzamides
Glucosidases
Hypoglycemic Agents
Incretins
Insulin

Reference

1. Sherifali D, Nerenberg K, Pullenayegum E, Cheng JE, Gerstein HC. The effect of oral antidiabetic agents on A1C levels: a systematic review and meta-analysis. Diabetes Care. 2010. 33:1859–1864.

2. Van de Laar FA, Lucassen PL, Akkermans RP, Van de Lisdonk EH, Rutten GE, Van Weel C. Alpha-glucosidase inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2005. (2):CD003639.

3. Rodier M, Richard JL, Monnier L, Mirouze J. Effect of long term acarbose (Bay g 5421) therapy on metabolic control of non insulin dependent (type II) diabetes mellitus. Diabete Metab. 1988. 14:12–14.

4. Vannasaeng S, Ploybutr S, Nitiyanant W, Peerapatdit T, Vichayanrat A. Effects of alpha-glucosidase inhibitor (acarbose) combined with sulfonylurea or sulfonylurea and metformin in treatment of non-insulin-dependent diabetes mellitus. J Med Assoc Thai. 1995. 78:578–585.

5. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. STOP-NIDDM Trail Research Group. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet. 2002. 359:2072–2077.

6. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. STOP-NIDDM Trail Research Group. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA. 2003. 290:486–494.

7. Hanefeld M, Cagatay M, Petrowitsch T, Neuser D, Petzinna D, Rupp M. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies. Eur Heart J. 2004. 25:10–16.

8. Landgraf R, Bilo HJ, Müller PG. A comparison of repaglinide and glibenclamide in the treatment of type 2 diabetic patients previously treated with sulphonylureas. Eur J Clin Pharmacol. 1999. 55:165–171.

9. Marbury T, Huang WC, Strange P, Lebovitz H. Repaglinide versus glyburide: a one-year comparison trial. Diabetes Res Clin Pract. 1999. 43:155–166.

10. Wolffenbuttel BH, Landgraf R. Dutch and German Repaglinide Study Group. A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Diabetes Care. 1999. 22:463–467.

11. Rosenstock J, Hassman DR, Madder RD, Brazinsky SA, Farrell J, Khutoryansky N, Hale PM. Repaglinide Versus Nateglinide Comparison Study Group. Repaglinide versus nateglinide monotherapy: a randomized, multicenter study. Diabetes Care. 2004. 27:1265–1270.

12. Hu S, Wang S, Fanelli B, Bell PA, Dunning BE, Geisse S, Schmitz R, Boettcher BR. Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide. J Pharmacol Exp Ther. 2000. 293:444–452.

13. Kim MK, Suk JH, Kwon MJ, Chung HS, Yoon CS, Jun HJ, Ko JH, Kim TK, Lee SH, Oh MK, Rhee BD, Park JH. Nateglinide and acarbose for postprandial glucose control after optimizing fasting glucose with insulin glargine in patients with type 2 diabetes. Diabetes Res Clin Pract. 2011. 92:322–328.

14. Bellomo Damato A, Stefanelli G, Laviola L, Giorgino R, Giorgino F. Nateglinide provides tighter glycaemic control than glyburide in patients with Type 2 diabetes with prevalent postprandial hyperglycaemia. Diabet Med. 2011. 28:560–566.

15. Marfella R, Barbieri M, Grella R, Rizzo MR, Nicoletti GF, Paolisso G. Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations. J Diabetes Complications. 2010. 24:79–83.

16. Lim S, An JH, Shin H, Khang AR, Lee Y, Ahn HY, Yoon JW, Kang SM, Choi SH, Cho YM, Park KS, Jang HC. Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC Study. Clin Endocrinol (Oxf). 2011 Sep 29 [Epub]. http://dx.doi.org/10.1111/j.1365-2265.2011.04240.x.

17. Mohan V, Yang W, Son HY, Xu L, Noble L, Langdon RB, Amatruda JM, Stein PP, Kaufman KD. Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India, and Korea. Diabetes Res Clin Pract. 2009. 83:106–116.

18. Hermansen K, Colombo M, Storgaard H, ØStergaard A, Kølendorf K, Madsbad S. Improved postprandial glycemic control with biphasic insulin aspart relative to biphasic insulin lispro and biphasic human insulin in patients with type 2 diabetes. Diabetes Care. 2002. 25:883–888.

19. Farcasiu E, Ivanyi T, Mozejko-Pastewka B, Birkus Z, Csog J, Kowalska I, Coetzer TF, Bulgurlu S, Schinzel B, Kiljanski J. Efficacy and safety of prandial premixed therapy using insulin lispro mix 50/50 3 times daily compared with progressive titration of insulin lispro mix 75/25 or biphasic insulin aspart 70/30 twice daily in patients with type 2 diabetes mellitus: a randomized, 16-week, open-label study. Clin Ther. 2011. 33:1682–1693.

20. Nauck MA, Duran S, Kim D, Johns D, Northrup J, Festa A, Brodows R, Trautmann M. A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia. 2007. 50:259–267.