Korean J Dermatol.
2011 Feb;49(2):155-158.
Imatinib Mesylate (Gleevec(TM))-induced Lichenoid Drug Eruption Improved by Tentative Dose-reduction and Topical Steroid
- Affiliations
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- 1Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea. snolomas@schmc.ac.kr
- 2Department of Dermatology, National Cancer Center, Seoul, Korea.
Abstract
- Imatinib mesylate (Gleevec(TM)) is an oral anticancer drug. It works as a selective and competitive inhibitor of tyrosine kinases such as bcr-abl protein, c-kit, and platelet-derived growth factor receptors (PDGFR). Gleevec(TM) is a first-line therapeutic agent for chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors, but causes various adverse cutaneous reactions. We herein report on a case of lichenoid drug eruption induced by Gleevec(TM) in a patient with a malignant gastrointestinal stromal tumor.
MeSH Terms
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Benzamides
Drug Eruptions
Gastrointestinal Stromal Tumors
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mesylates
Phosphotransferases
Piperazines
Pyrimidines
Receptors, Platelet-Derived Growth Factor
Tyrosine
Imatinib Mesylate
Benzamides
Mesylates
Phosphotransferases
Piperazines
Pyrimidines
Receptors, Platelet-Derived Growth Factor
Tyrosine
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