Korean J Dermatol.  2007 Feb;45(2):194-196.

A Case of Drug Eruption with Periorbital Edema and Exfoliative Dermatitis Induced by Imatinib Mesylate (STI571, Gleevec(TM))

• Joo YH
• Min SU
• Lee DH
• Suh DH

Abstract

STI571 (imatinib mesylate, Gleevec(TM)), a selective inhibitor of the bcr-abl, c-kit, platelet-derived growth factor receptor tyrosine kinases, is a new anticancer drug used for chronic myelogenous leukemia and gastrointestinal stromal tumors. Cutaneous adverse reactions of periorbital edema and exfoliative dermatitis related to STI571 are rare and there have been no previous reports in the Korean literature. We herein report a case of periorbital edema and exfoliative dermatitis due to STI571 and discuss the possible mechanism of periorbital edema related to STI571.

Keyword

Drug eruption; Exfoliative dermatitis; Imatinib mesylate; Periorbital edema; STI571

MeSH Terms

Dermatitis, Exfoliative*
Drug Eruptions*
Edema*
Gastrointestinal Stromal Tumors
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mesylates*
Phosphotransferases
Receptors, Platelet-Derived Growth Factor
Tyrosine
Imatinib Mesylate
Mesylates
Phosphotransferases
Receptors, Platelet-Derived Growth Factor
Tyrosine