- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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- Imatinib-induced hepatitis treated by corticosteroids in a patient with metastatic gastrointestinal stromal tumor
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Kang MK, Lee HJ, Choi JH
- KMID: 2449330
- Yeungnam Univ J Med.
- 2019 May;36(2):155-158.
- doi: 10.12701/yujm.2019.00115
Imatinib mesylate is currently used as the first-line treatment for metastatic gastrointestinal stromal tumors (GISTs). Imatinib-induced hepatotoxicity in patients with GIST is very rare. Its features vary from subclinical elevation... -
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- ABCB1 and BMI1 mRNA expression in patients with chronic myeloid leukemia: impact on imatinib efficacy
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Bedewy AM, Elmaghraby SM, Kandil NS
- KMID: 2451057
- Blood Res.
- 2019 Mar;54(1):57-62.
- doi: 10.5045/br.2019.54.1.57
BACKGROUND: ATP-binding cassette transporters are important in the mechanism of multidrug resistance. ABCB1 displays a high affinity for imatinib. BMI1 is a polycomb group protein thought to be overexpressed in... -
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- Outcome and prognostic factors of children with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib followed by allogeneic hematopoietic cell transplantation in first remission
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Shin J, Lee NY, Kim S, Lee JW, Jang PS, Chung NG, Cho B
- KMID: 2451055
- Blood Res.
- 2019 Mar;54(1):45-51.
- doi: 10.5045/br.2019.54.1.45
BACKGROUND: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a subset of ALL with poor prognosis. Here, we analyzed the outcomes and prognostic factors of children with Ph+ ALL who... -
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- Anti-growth Effects of Imatinib and GNF5 via Regulation of Skp2 in Human Hepatocellular Carcinoma Cells
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Kim SH, Kim MO, Kim KR
- KMID: 2447448
- J Cancer Prev.
- 2018 Dec;23(4):170-175.
- doi: 10.15430/JCP.2018.23.4.170
BACKGROUND: Human hepatocellular carcinoma (HCC) is a common liver tumor and the main cause of cancer-related death. Tyrosine kinase inhibitors, such as imatinib and GNF5 which were developed to treat... -
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- The Composition of Pharmaceutical Expenditure in National Health Insurance and Implications for Reasonable Spending
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Lee HJ
- KMID: 2438587
- Health Policy Manag.
- 2018 Dec;28(4):360-368.
- doi: 10.4332/KJHPA.2018.28.4.360
BACKGROUND: The proportion of pharmaceutical expenditure out of total health-care expenditure in South Korea is high. In 2016, 25.7% of national health insurance (NHI) spending was for pharmaceuticals. Given the... -
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- Postoperative Cure for Metastatic Gastrointestinal Stromal Tumor
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Park EH, Kim JI, Cheung DY, Park SH
- KMID: 2428015
- Korean J Helicobacter Up Gastrointest Res.
- 2018 Dec;18(4):264-270.
- doi: 10.7704/kjhugr.2018.18.4.264
Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor derived from Cajal cells originating from the myotonic plexus. The expression of tyrosine kinase (KIT) membrane receptors that are active on KIT... -
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- Peripheral neuropathy associated with imatinib therapy for chronic myeloid leukemia
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Kavanagh S, Bril V, Lipton JH
- KMID: 2451040
- Blood Res.
- 2018 Jun;53(2):172-174.
- doi: 10.5045/br.2018.53.2.172
No abstract available. -
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- Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases
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Kim YJ, Lee WJ, Won CH, Choi JH, Lee MW
- KMID: 2419178
- Ann Dermatol.
- 2018 Jun;30(3):345-347.
- doi: 10.5021/ad.2018.30.3.345
We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with... -
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- Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib
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Kim DS, Lee S, Choi CW
- KMID: 2411596
- Korean J Intern Med.
- 2018 May;33(3):642-644.
- doi: 10.3904/kjim.2016.100
No abstract available. -
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- Two different KIT mutations may lead to different responses to imatinib in metastatic gastrointestinal stromal tumor
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Yim E, An HJ, Cho U, Kim Y, Kim SH, Choi YG, Shim BY
- KMID: 2411555
- Korean J Intern Med.
- 2018 Mar;33(2):432-434.
- doi: 10.3904/kjim.2015.295
No abstract available. -
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- Ultrasound-Guided Intraoperative Radiofrequency Ablation and Surgical Resection for Liver Metastasis from Malignant Gastrointestinal Stromal Tumors
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Yoon IS, Shin JH, Han K, Kim PN, Kim KH, Kang YK, Ko HK
- KMID: 2425109
- Korean J Radiol.
- 2018 Feb;19(1):54-62.
- doi: 10.3348/kjr.2018.19.1.54
OBJECTIVE: To evaluate the effectiveness, safety, and feasibility of intraoperative radiofrequency ablation (IORFA) under ultrasound guidance for the treatment of liver metastases from gastrointestinal stromal tumors (GISTs). MATERIALS AND METHODS: From... -
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- Uveoretinal Adverse Effects Presented during Systemic Anticancer Chemotherapy: a 10-Year Single Center Experience
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Cho AR, Yoon YH, Kim JG, Kim YJ, Lee JY
- KMID: 2402997
- J Korean Med Sci.
- 2018 Feb;33(7):e55.
- doi: 10.3346/jkms.2018.33.e55
BACKGROUND: The present study describes our 10-year experience with uveoretinal adverse events that manifest because of chemotherapy. METHODS: A retrospective chart review was performed for all patients who presented to the... -
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- Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib
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Bombeccari GP, Garagiola , Pallotti F, Rossi M, Porrini M, Giannì AB, Spadari F
- KMID: 2400060
- Maxillofac Plast Reconstr Surg.
- 2017 Dec;39(12):37.
- doi: 10.1186/s40902-017-0136-y
BACKGROUND: Imatinib mesylate is an inhibitor of the tyrosine kinase Bcr–Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Dermatological side effects include superficial oedema, pustular eruption,... -
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- A Case of Lichenoid Drug Eruption Associated with Imatinib Mesylate
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Seol JE, Park SH, Kim DH, Kim H, Kang JN
- KMID: 2396849
- Korean J Dermatol.
- 2017 Nov;55(9):621-622.
No abstract available. -
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- Adrenal Gland Metastasis of a Gastrointestinal Stromal Tumor
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Kang HJ, Cho HJ, Kim KH, Joung MK, Shin JU, Jin SS
- KMID: 2392334
- Korean J Med.
- 2017 Oct;92(5):471-475.
- doi: 10.3904/kjm.2017.92.5.471
A 56-year-old male with a gastrointestinal stromal tumor (GIST) underwent surgical resection of the tumor. Nine months after surgery, imatinib therapy was initiated because of the discovery of metastatic tumors... -
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- LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21
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Zhou X, Yuan P, Liu Q, Liu Z
- KMID: 2389380
- Biomol Ther.
- 2017 Sep;25(5):490-496.
- doi: 10.4062/biomolther.2016.162
Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib resistance... -
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- Myeloid and lymphoid neoplasm with eosinophilia and abnormalities of PDGFRB presenting as congestive heart failure and hypereosinophilia
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Kwon JW, Kwon JH, Her AY
- KMID: 2387653
- Allergy Asthma Respir Dis.
- 2017 Jul;5(4):232-236.
- doi: 10.4168/aard.2017.5.4.232
Hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by persistent hypereosinophilia with the evidence of organ dysfunction caused by eosinophilic involvement. HES can be induced by various secondary causes, including... -
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- Efficacy and Safety of Regorafenib in Korean Patients with Advanced Gastrointestinal Stromal Tumor after Failure of Imatinib and Sunitinib: A Multicenter Study Based on the Management Access Program
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Son MK, Ryu MH, Park JO, Im SA, Kim TY, Lee SJ, Ryoo BY, Park SR, Kang YK
- KMID: 2378107
- Cancer Res Treat.
- 2017 Apr;49(2):350-357.
- doi: 10.4143/crt.2016.067
PURPOSE: The aim of this study was to confirm the efficacy and safety of regorafenib for advanced gastrointestinal stromal tumors (GISTs) reported in the GRID phase III trial in Korean... -
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- A rare case of osteonecrosis of the jaw related to imatinib
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Viviano M, Rossi M, Cocca S
- KMID: 2377016
- J Korean Assoc Oral Maxillofac Surg.
- 2017 Apr;43(2):120-124.
- doi: 10.5125/jkaoms.2017.43.2.120
Osteonecrosis of the jaw (ONJ) is commonly described as an adverse effect of the use of bisphosphonates. A few cases of ONJ associated with tyrosine kinase inhibitors (sunitinib, imatinib) have... -
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